Clinical trials: Dry Eye, completed
Atrophy, Geographic
Clinical Study to Investigate Safety and Efficacy of GSK933776 in Adult Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration
The purpose of this study is to determine the safety and efficacy of GSK933776 in the treatment of geographic atrophy secondary to age-related macular degeneration.
- Trial name
- NCT01342926
- Testing
- GSK933776
- Where
- 41 sites in United States, Canada
- Volunteers
- 191 people
- Sponsor
- GlaxoSmithKline
Systemic Lupus Erthematosus, Sjogren's Syndrome
Omalizumab for Lupus
Background: Systemic Lupus Erythematosus (SLE or lupus) is an autoimmune disease, which means the body's immune system mistakenly attacks healthy tissue resulting in inflammation and tissue damage.
- Trial name
- NCT01716312
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Dry Eye
Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease
Evaluate the tolerability, efficacy and safety of VOS versus Restasis® in subjects with mild to moderate Dry Eye Disease (DED).
- Trial name
- NCT03597139
- Testing
- Voclosporin Ophthalmic Solution, Restasis®
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Dry Eye
Study Assessing Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients
The purpose of this study is to evaluate if DE-101 ophthalmic suspension will safely and effectively improve signs and or symptoms of dry eye disease.
- Trial name
- NCT01118754
- Testing
- DE-101 ophthalmic suspension, DE-101 ophthalmic suspension vehicle
- Where
- 10 sites in United States
- Volunteers
- 132 people
- Sponsor
- Santen Inc.
Dry Eye
Study of the Safety and Efficacy of OmegaD Softgels in the Treatment of Dry Eye Disease
This is a phase 3 study to evaluate the safety and efficacy of OmegaD softgels for the treatment of dry eye disease. A daily dose of 2 OmegaD softgels dosed orally BID will be compared to 2 placebo softgels dosed orally BID for…
- Trial name
- NCT02980224
- Testing
- OmegaD
- Where
- 11 sites in United States
- Volunteers
- 180 people
- Sponsor
- OmegaD LLC
Dry Eye
Assess the Safety and Efficacy of CsA Ophthalmic Gel in Subjects With Moderate to Severe Dry Eye Disease
The purpose of this study is to explore the efficacy and safety of CsA ophthalmic gel in the treatment of moderate to severe dry eye disease .
- Trial name
- NCT04541888
- Testing
- CsA Ophthalmic Gel, Hypromellose Eye Drop
- Where
- China
- Volunteers
- 644 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Keratoconjunctivitis Sicca, Xeropthalmia
Acupuncture Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of acupuncture in the treatment of moderate to severe dry eye by replicating the study design of the previous protocol and to see the study through to its…
- Trial name
- NCT00554879
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Dry Eye
Acute Comfort and Haze Profile of FID 114657
The purpose of this study is to describe the acute comfort and haze profile of FID 114657 in dry eye patients.
- Trial name
- NCT00983203
- Testing
- FID 114657 ORB Preserved Ocular Emulsion, Soothe XP Lubricant Eye Drops
- Volunteers
- 20 people
- Sponsor
- Alcon Research
Dry Eye Disease
A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Eye Disease
The objective of the study is to assess the safety, efficacy, optimum dosage, and dosing regimen of K-161 in adult subjects with moderate to severe dry eye disease.
- Trial name
- NCT04084483
- Testing
- K-161
- Where
- 4 sites in United States
- Volunteers
- 238 people
- Sponsor
- Kowa Research Institute, Inc.
Dry Eye
Rexon-Eye in Dry Eye
Resono Ophthalmic has developed Rexo-Eye in 2014, a QMR-based patented instrument which is hypothesised to stimulate physiological cellular regeneration and reactivate the tear system by stimulating and reactivating the lacrimal…
- Trial name
- NCT04320563
- Testing
- Rexon-eye
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Meibomian Gland Dysfunction
The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression
The study aims to determine the impact of Meibomian Gland Dysfunction (MGD) dry eye on low contrast black/white (luminance) and cone color sensitivity performance and improvement in these functions after in-house non-invasive…
- Trial name
- NCT05713981
- Testing
- Meibomian gland (MG) expression
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Age-Related Maculopathy, Age-Related Maculopathies
Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration
The purpose of this study is to determine the safety and tolerability of RN6G in patients with dry, age-related macular degeneration.
- Conditions
- Age-Related Maculopathy, Age-Related Maculopathies, Eye Diseases, Retinal Degeneration
- Trial name
- NCT00877032
- Testing
- RN6G
- Where
- 20 sites in United States
- Volunteers
- 57 people
- Sponsor
- Pfizer
Dry Eye Symptom, Eye Fatigue
Effects and Safety of Steam Eye Mask With Acupoints Stimulation
To evaluate the effects and safety of the steam eye mask with acupoints stimulation by the moist heat of approximately 40 degree C for 20 minutes and massage acupoints on eyebrows for eye fatigue, dry eye symptoms and…
- Trial name
- NCT04584216
- Testing
- Steam Eye Mask with acupoints stimulation, Steam Eye Mask
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kao (Taiwan) Corporation
Lymphoma, Salivary Gland Disease
Natural History of Salivary Gland Dysfunction and Sjogren's Syndrome
This study will follow patients with salivary gland dysfunction to identify the long-term course of this disorder and its effects on the mouth, oral function, and overall health.
- Conditions
- Lymphoma, Salivary Gland Disease, Sjogren's Syndrome, Xerostomia
- Trial name
- NCT00001852
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye Syndromes, Sjögren Syndrome
A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome
The purpose of this study is to evaluate the effectiveness of fluorometholone combined with sodium hyaluronate eye drops in the treatment of Sjögren syndrome.
- Trial name
- NCT02011776
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Santen Pharmaceutical(China) Co.,LTD
Dry Eye Disease
CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED)
The objective of this study is to assess the efficacy, safety, and tolerability of CyclASol Ophthalmic Solution in comparison to vehicle for the treatment of the signs and symptoms of DED.
- Trial name
- NCT03292809
- Testing
- CyclASol topical ocular, eye drops, Vehicle topical ocular, eye drops
- Where
- 9 sites in United States
- Volunteers
- 328 people
- Sponsor
- Novaliq GmbH
Dry Eye
Lipid Layer Thickness Pre and Post Lid Scrubs With Cliradex
Tears play a vital role in vision. A thin layer of tears is always present to cover the surface of the eye for optimal comfort and vision.
- Trial name
- HONDA (NCT02493244)
- Testing
- Cliradex
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Macular Degeneration Advanced, Macular Degeneration, Senile
Visual Rehabilitation Through Acoustic Biofeedback With Retimax Vision Trainer in Patients With Advanced Age-related Macular Degeneration
At present there are no real therapies able to improve visual performance in patients with age-related macular degeneration, atrophic type.
- Conditions
- Macular Degeneration Advanced, Macular Degeneration, Senile, Macular Degeneration, Dry, Macular Scar
- Trial name
- NCT04084587
- Testing
- Retimax Vision Trainer
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Modena and Reggio Emilia
Dry Eye
OTX-14-006: A Phase 2 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Dry Eye
The objective of the study was to evaluate the efficacy and safety of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of the signs and symptoms of dry…
- Trial name
- NCT02468700
- Testing
- Dexamethasone
- Volunteers
- 43 people
- Sponsor
- Ocular Therapeutix, Inc.
Ocular Hypertension, Open Angle Glaucoma
Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED)
To evaluate if preservative free cosopt is well tolerated in patients with Open angle glaucoma (OAG) or Ocular hypertension (OH) with dry eyes.
- Trial name
- DISCOVER (NCT00545064)
- Testing
- dorzolamide hydrochloride (+) timolol maleate
- Volunteers
- 176 people
- Sponsor
- Merck Sharp & Dohme LLC
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