Clinical trials: Dry Eye, completed
Primary Sjögren's Syndrome (pSS)
Clinical Study to Investigate the Efficacy of Orally Administered SA001 in Patients With Primary Sjögren's Syndrome
This is a phase2a, multicenter, double-blind, placebo control, randomized study to investigate the efficacy and safety of SA001 in subjects with pSS.
- Trial name
- NCT05269810
- Testing
- SA001 Low dose, SA001 Mid dose, SA001 High dose
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samjin Pharmaceutical Co., Ltd.
Dry Eye
Evaluation of Safety and Tolerability of Ocular Lubricants
The purpose of this study is to evaluate the safety profile of test formulations for an artificial tear product versus a comparator product.
- Trial name
- NCT05573360
- Testing
- NGF5-A test formulation, NGF4-B test formulation, NGF6-B test formulation
- Where
- 2 sites in Australia
- Volunteers
- 41 people
- Sponsor
- Alcon Research
Sjogren's Disease
Tolerance and Efficacy of Rituximab in Sjogren's Disease
CLINICAL PHASE II INDICATION Sjogren's syndrome RATIONALE Sjögren's syndrome (SS) is an autoimmune disorder affecting 0.2% to 3% of the general population.
- Trial name
- TEARS (NCT00740948)
- Testing
- Rituximab (mabthera) Injection
- Where
- 14 sites in France
- Volunteers
- 122 people
- Sponsor
- University Hospital, Brest
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Allergic Conjunctivitis
Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients
Multicentre, Double blind, Randomized, Comparative Study(comparing N-acetyl-aspartyl-glutamic acid(NAAGA) in Abak preservative free device versus SALINE in Abak preservative free device.
- Trial name
- NCT01203540
- Testing
- NAABAK eyedrops, Saline eyedrops
- Where
- 2 sites in South Korea
- Volunteers
- 21 people
- Sponsor
- Laboratoires Thea
Age Related Macular Degeneration (AMD), Age Related Macular Degeneration
Evaluating the Relationship Between Function and Structure Using Data From a GA Natural History Cohort
Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration that leads to progressive and irreversible vision loss.
- Conditions
- Age Related Macular Degeneration (AMD), Age Related Macular Degeneration, AMD, Geographic Atrophy
- Trial name
- ARCHERY (NCT07424235)
- Volunteers
- 60 people
- Sponsor
- IRCCS Ospedale San Raffaele
Aqueous Deficient Dry Eye, Meibomium Gland Dysfunction
Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation
Compare the objective tear film dynamic measurements in three different populations (MGD [Meibomium Gland Dysfunction], ADDE [Aqueous Deficient Dry Eye] and normal/control [non-dry eye]) and the subjective experience before and…
- Trial name
- NCT01128049
- Testing
- Subjective Questionnaire, Measurement with wavefront sensor (right eye, then left eye), Instill Saline Drop
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Xerostomia, Sjogren's Syndrome
Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome
The purpose of this study is to exploratively investigate the clinical efficacy of rebamipide on dry mouth in patients with Sjögren's syndrome in comparison with placebo.
- Trial name
- NCT00233363
- Testing
- Rebamipide
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dry Eye Disease
The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease
The objective of this study is to compare the safety and efficacy of OK-101 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT05759208
- Testing
- OK-101
- Where
- 6 sites in United States
- Volunteers
- 240 people
- Sponsor
- Okyo Pharma Ltd
Dry Eye Disease (DED), Dry Eye
Proteomics Analysis of Human Tears in the Diagnosis and Management of Dry Eye Disease
In this study, the initial tear proteome profiles in Dry Eye Disease (DED) patients, the safety and effectiveness of using an EC certificate DED treatment device in DED management, together with the associated global tear…
- Trial name
- NCT07175909
- Testing
- The Rexon-Eye, an electrotherapy device utilizing Quantum Molecular Resonance (QMR) technology
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- The Hong Kong Polytechnic University
Dysfunctional Tear Syndrome
Clinical Evaluation of the InflammaDry Device for Detecting Dry Eye
InflammaDry is a rapid diagnostic test for the detection of elevated levels of Matrix Metalloproteinase-9 (MMP-9) protein in tear fluid.
- Trial name
- NCT01692964
- Testing
- InflammaDry
- Where
- 4 sites in United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening
Contact Lens, Contact Lens Discomfort
Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness
The most common reason for contact lens discontinuation is contact lens discomfort. The investigators believe that inflammation plays a role in contact lens discomfort and the use of lifitegrast 5% ophthalmic solution may reduce…
- Conditions
- Contact Lens, Contact Lens Discomfort, Contact Lens Dryness
- Trial name
- NCT03686878
- Testing
- Lifitegrast
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- EV Clinical Trials
Dry Eye Disease
Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome
The study is designed to assess the safety and efficacy of Vismed®, a special eye drop containing sodium hyaluronate, in the treatment of dry eye syndrome.
- Trial name
- NCT00599716
- Testing
- sodium hyaluronate, vehicle
- Where
- 10 sites in United States
- Volunteers
- 300 people
- Sponsor
- Lantibio
Dry Eye Disease
A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
A Multicenter, Phase 3, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Environment Exposure Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap
- Trial name
- NCT06424444
- Testing
- Reproxalap ophthalmic solution (0.25%), Vehicle ophthalmic solution
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye Disease
Study of Safety and Performance of a Novel Ocular Lubricant in Subjects With Dry Eye Disease
The purpose of this study is to evaluate and demonstrate the efficacy and safety of an investigational ocular lubricant formulation in patients with mild to moderate dry eye disease (DED).
- Trial name
- NCT06444516
- Testing
- FID123300 ocular lubricant
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- Alcon Research
Dry Eye Syndromes
Bilateral, Masked Comparison of PEG-400 Based Artificial Tear vs. Systane for Dry Eye Signs, Symptoms & Refractive Regression Associated With Myopic Laser in Situ Keratomilieusis (LASIK).
This study will evaluate and compare 2 artificial tears in their ability to reduce post LASIK dry eye signs and symptoms. The secondary endpoint of this study is to evaluate refractive regression in these patients.
- Trial name
- NCT00620893
- Testing
- PEG- 400 based artificial tear, Systane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bp Consulting, Inc
Dry Eye Syndrome
A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome
To determine the effect of Essential Fatty Acids (EFA's) on Meibomian Gland lipids and aqueous tear production in patients with "dry eyes".
- Trial name
- NCT00344721
- Testing
- Omega-3 fatty acid supplement
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dry Eye Symptom, Eye Fatigue
Effects and Safety of Steam Eye Mask With Acupoints Stimulation
To evaluate the effects and safety of the steam eye mask with acupoints stimulation by the moist heat of approximately 40 degree C for 20 minutes and massage acupoints on eyebrows for eye fatigue, dry eye symptoms and…
- Trial name
- NCT04584216
- Testing
- Steam Eye Mask with acupoints stimulation, Steam Eye Mask
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kao (Taiwan) Corporation
Dry Eye
Rexon-Eye in Dry Eye
Resono Ophthalmic has developed Rexo-Eye in 2014, a QMR-based patented instrument which is hypothesised to stimulate physiological cellular regeneration and reactivate the tear system by stimulating and reactivating the lacrimal…
- Trial name
- NCT04320563
- Testing
- Rexon-eye
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Fibromyalgia, Multiple Sclerosis
e-Mobile Tablet for People With Chronic Conditions
Maintaining a healthy diet and engaging in routine physical activity may help decrease severity of symptoms, prevent secondary conditions, and slow functional decline in people with disabling neuromusculoskeletal conditions.
- Conditions
- Fibromyalgia, Multiple Sclerosis, Osteoarthritis, Sjögren's Syndrome
- Trial name
- NCT02833311
- Testing
- Computer Tablet Group, Paper and Pencil Group, Contact Control Group
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Case Western Reserve University