Clinical trials: Dry Eye
Sjogren's Syndrome
Olfactory and Taste Disturbances in Sjogren's Syndrome
Sjögren syndrome is an autoimmune disease, responsible for xerostomia and xerophthalmia. Other organs and tissues can be affected: the skin, vaginal and nasal mucous membranes.
- Trial name
- TOG_SJOGREN (NCT04909112)
- Testing
- Evaluation of olfactory function, Evaluation of taste function, Evaluation of (intra-nasal and oral) trigeminal functions
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Dry Eye Syndrome
Tears Substitutions and Their Effects on Higher Order Aberrometery
Hypothesis is that tear substitutions cause blur after they are instilled. The investigators will use aberrometry as a measurement over time after a tear formulation is used and try to determine if there are any measurable change…
- Trial name
- NCT00812721
- Testing
- Preservative Free Saline, Optive, Refresh Moderate/Severe
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Gina Rogers
Dry Eye Disease
Femtosecond Small Incision Lenticular Extraction in Comparison to Femtosecond Laser Insitu Keratomileusis Regarding Dry Eye Disease
Comparison of femtosecond small incision lenticule extraction (FS-SMILE) versus Femtosecond laser Insitu Keratomileusis (FS-LASIK) regarding dry eye disease (DED) and corneal sensitivity (CS) after those refractive surgeries.
- Trial name
- NCT04477421
- Testing
- FS-SMILE, S-LASIK
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Al-Rasheed University College
Meibomian Gland Dysfunction, Sjögren's Syndrome
Sjögren's Syndrome Is Associated With Meibomian Gland Dysfunction
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03434106
- Testing
- liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- LanZhou University
Keratoconjunctivitis Sicca, Dry Eye Disease
Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)
The purpose of the study is to evaluate the efficacy of SAR 1118 Ophthalmic Solution (5.0%) compared to placebo in the treatment of Dry Eye.
- Trial name
- OPUS-1 (NCT01421498)
- Testing
- Lifitegrast
- Where
- 13 sites in United States
- Volunteers
- 588 people
- Sponsor
- Shire
Diabetic Eye Problems
Diquafosol vs Hyaluronic Acid for Diabetic Dry Eye
Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells.
- Trial name
- NCT05682547
- Testing
- 3% Diquafosol tetrasodium, 0.1% hyaluronate
- Where
- China
- Volunteers
- 99 people
- Sponsor
- He Eye Hospital
Early to Moderate Dry Age-Related Macular Degeneration
Study of Application of Transcutaneous Pulsed Electrical Stimulation Around Eye in Age-related Macular Degeneration
This study aims to evaluate the safety and efficacy of applying pulse electrical stimulation around eyes of age-related macular patients.
- Trial name
- NCT05259371
- Testing
- Transcutaneous Pulsed Electrical Stimulation (Device: Nu Eyne M02)
- Where
- 3 sites in South Korea
- Volunteers
- 25 people
- Sponsor
- Nu Eyne Co., Ltd.
Dry Eye Disease, oGVHD
2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD
Evaluate and study the immunologic changes to the ocular surface in cancer patients.
- Trial name
- NCT04946721
- Testing
- The standard care exam and biological specimens' collection
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Dry Eye Syndrome
Systane Clinical Experience Study
To evaluate the physical effect of SYSTANE QID in people that have moderate to severe dry eyes and to establish doctor confidence to prescribe Systane.
- Trial name
- NCT00818909
- Testing
- Systane
- Volunteers
- 941 people
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Dry Eye Disease
Investigating the Effect of At Home Thermal Therapy on Dry Eye Patients With Meibomian Gland Dysfunction
The purpose of this pilot study is to determine the feasibility of at home thermal therapy with a wireless, portable device, as an effective management of Meibomian Gland Dysfunction.
- Trial name
- NCT03291704
- Testing
- Thermal therapy device
- Volunteers
- 20 people
- Sponsor
- UMay Care Inc.
Dry Eye Disease
A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution Compared With Vehicle in Patients With Dry Eye Disease.
Primary objective To evaluate the efficacy of 5 μg/mL and 10 μg/mL concentrations of the new formulation of rhNGF ophthalmic solution versus vehicle, in order to demonstrate superiority of at least 1 of the concentrations over…
- Trial name
- REDUCO (NCT06244316)
- Testing
- rhNGF 5 μg/mL, rhNGF 10 μg/mL
- Where
- 14 sites in United States, Italy
- Volunteers
- 317 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye
Phase 2b Controlled Study of Dosing Techniques - Part B
Double-masked, dose-response of two concentrations of IVW-1001
- Trial name
- NCT07161011
- Testing
- IVW-1001 Ophthalmic Eyelid Wipe 0.2%, IVW-1001 Ophthalmic Eyelid Wipe 0.4%
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- IVIEW Therapeutics Inc.
Dry Eye
Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Eye Ointment
The purpose of this study is to compare the comfort and blurriness of the investigational lubricant eye drop with a marketed artificial tear ointment.
- Trial name
- NCT01076998
- Testing
- Lubricant eye drop FID 115958D, Refresh PM Ointment
- Volunteers
- 24 people
- Sponsor
- Alcon Research
Contact Lens Complication, Dry Eye
Correlation Study of Corneal Nerve Changes and Dry Eye in Contact Lens Wearers
This study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(CLADE) patients and further discuss the role of corneal nerve in the genesis and development of CLADE.
- Trial name
- NCT04663529
- Testing
- contact lens
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Dry Age-related Macular Degeneration, Vision Impairment and Blindness
Vision Improvement for Legally Blind Dry AMD Patients
This retrospective observational study is intended to assess the feasibility of using a nonsignificant risk device for vision improvement for legally blind dry AMD patients.
- Trial name
- NCT04875234
- Testing
- Clear-K Low Vision Aid Treatment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Optimal Acuity Corporation
Sjögren, Sjogren Disease
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
A phase 1b, open-label study of CLN-978 administered subcutaneously in patients with active, moderate to severe Sjogren's Disease.
- Conditions
- Sjögren, Sjogren Disease, Sjogren's Syndrome
- Trial name
- NCT07041099
- Testing
- CLN-978
- Where
- 14 sites in United States, France and 2 more
- Volunteers
- 36 people
- Sponsor
- Cullinan Therapeutics Inc.
Ocular Dryness, Ocular Irritation
Dry Eye and Irritation Comparison of Latanoprost With the Preservative Versus Travoprost Without Preservative
Although Benzalkonium chloride (BAC) has been used as a preservative for many years, many studies have demonstrated that prolonged use of topical ocular medications preserved with BAC may exacerbate sequelae associated with…
- Conditions
- Ocular Dryness, Ocular Irritation, Open-Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT00803387
- Testing
- Travaprost without BAC (Travatan Z)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Air Force
Dry Eye
The Effect of a Novel Blueberry Supplement on Dry Eye Disease
The objective of this study is to evaluate the efficacy of a novel oral supplement (gummy bear) with blueberry powder on reducing dry eye signs and symptoms and assess its safety.
- Trial name
- PLUM (NCT05027087)
- Testing
- Blueberry gummy
- Where
- Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- SightSage Foods and Nutrition Inc.
Dry Eye
Study of Blinking as a Function of Tear Film Quality
The goal of this study is to better understand how eye blinking behavior is linked to the stability of the tear film, in adults aged 18 to 65 years, with or without symptoms of dry eye.
- Trial name
- WINK (NCT07499193)
- Testing
- Blink behaviour
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Essilor International
Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA)
A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases
The goal of this clinical trial is to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and efficacy of QLS2416 injection in participants with autoimmune diseases (AID).
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA), Primary Sjögren's Syndrome (pSS), Systemic Sclerosis (SSc)
- Trial name
- NCT07906145
- Testing
- QLS2416 Injection
- Volunteers
- 76 people
- Sponsor
- Shanghai Qilu Pharmaceutical Research and Development Center LTD