Clinical trials: Dry Eye, completed
Dry Eye
Safety and Efficacy Study of DE-110 Ophthalmic Suspension for the Treatment of Dry Eye Disease
Investigate the Safety and Efficacy of Two Concentrations of DE-110 Compared to Placebo for the Treatment of Dry Eye Disease
- Trial name
- NCT01239069
- Testing
- DE-110 ophthalmic suspension high dose, DE-110 ophthalmic suspension low dose
- Where
- 14 sites in United States
- Volunteers
- 140 people
- Sponsor
- Santen Inc.
Dry Eye Syndromes
A Study of KCT-0809 in Patients With Dry Eye Syndromes
The purpose of this study is to evaluate the efficacy and safety of KCT-0809 compared to placebo in patients with dry eye syndromes.
- Trial name
- NCT01211951
- Testing
- KCT-0809
- Where
- Japan
- Volunteers
- 160 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- STRIDE 1 (NCT02813265)
- Testing
- KPI-121 0.25% Ophthalmic Suspension, Vehicle of KPI-121 0.25% Ophthalmic Suspension
- Where
- 60 sites in United States
- Volunteers
- 918 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Dry Eye Syndromes
Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group
A Multicenter, Randomized, Double-blind Phase Ⅲ Study of Cyclosporine Ophthalmic Soution Group and Cyclosporine Ophthalmic Suspension Group 12 Weeks After Treatment in Moderate to Severe Dry Eye Disease
- Trial name
- Cyclosporine (NCT01768312)
- Testing
- Cyclosporine ophthalmic solution
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Dry Eye
Study on Curative Effect and Mechanism of Acupuncture on Neuropathic Pain in Dry Eye Disease
This project is designed as a prospective, randomized, open, controlled clinical trial. For the first time, acupuncture was applied to the treatment of dry ocular neuropathic pain.
- Trial name
- NCT04668131
- Testing
- Sodium hyaluronate eye drops, acupuncture
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Meibomian Gland Dysfunction, Dry Eye
Evaluation of Low-Level Light Therapy on Meibomian Glands Study
The goal of this clinical trial is to examine the effect of low-level light therapy (LLLT) on meibomian gland dysfunction and dry eye disease. The main questions it aims to answer are: 1.
- Trial name
- ELOM (NCT05859295)
- Testing
- Red Low-Level Light Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Houston
Dry Eye Disease, Retinal Nerve Fiber Layer
Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers
This study aimed to examine the impact of long-term smoking on dry eye parameters and retinal nerve fiber layer thickness in individuals who are chronic smokers.
- Conditions
- Dry Eye Disease, Retinal Nerve Fiber Layer, Chronic Smoking
- Trial name
- NCT07028736
- Testing
- Dry eye assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Dry Eye
20-20-20 Rule Plus Artificial Tears for Dry Eye
This study is for anyone struggling with dry, tired, or uncomfortable eyes, especially from long hours on screens. Investigators all know that feeling after staring at a laptop or phone too long.
- Trial name
- NCT07896395
- Testing
- Artificial Tears (AT), 20/20/20 rule
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Dry Eye
The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
The purpose of this study was to evaluate the ability of SYSTANE® BALANCE dosed 4 times a day for 30 days to increase non-invasive tear film break up time over baseline, compared to a saline control, in dry eye subjects with…
- Trial name
- NCT01718028
- Testing
- Propylene glycol 0.6% ocular emulsion, Sodium chloride 0.9% saline solution
- Where
- Argentina
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Safety and Tolerability of Artificial Tears in Dry Eye Subjects
The safety and tolerability of two new artificial tears will be compared to a currently-available artificial tear in subjects with dry eye. Each subject will receive all three products in a randomly assigned order.
- Trial name
- NCT00932477
- Testing
- Formulation 1: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear, Formulation 2: Carboxymethylcellulose Sodium, Glycerin and Polysorbate 80, based artificial tear, Glycerin and Polysorbate 80 based artificial tear
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Allergan
Dry Eye
Study to Evaluate a Contact Lens Lubricating and Rewetting Drop
The objective of this study is to evaluate the product performance of investigational lubricating and rewetting drops.
- Trial name
- NCT01267656
- Testing
- Lubricating and Rewetting Drops, AMO Blink Contacts Lubricant Eye Drops
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Syndrome
Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome
The purpose of this study is to evaluate the efficacy and safety of rebamipide ophthalmic suspension in subjects with dry eye syndrome.
- Trial name
- NCT01632137
- Testing
- Rebamipide 2% ophthalmic suspension
- Where
- 34 sites in United States
- Volunteers
- 564 people
- Sponsor
- Kubota Vision Inc.
Sjögren's Syndrome, Xerostomia
The Effect of Chewing Gum, Exercises of the Tongue, Lip, Jaw on Salivation, Xerostomia, Dysphagia in Sjögren's Syndrome
Sjögren's syndrome (SS) is a chronic, systemic and autoimmune disease characterized by inflammation, fibrosis and dysfunction of exocrine glands such as tear and salivary glands.
- Conditions
- Sjögren's Syndrome, Xerostomia, Dysphagia, Salivary Flow Rate
- Trial name
- SS (NCT05680064)
- Testing
- Tongue, lip, chin exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Saglik Bilimleri Universitesi
Dry Eye, Sjogren's Syndrome
Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye
Severe dry eye is a debilitating ocular disease resulting in loss of vision, reduced day-to-day function and significant discomfort.
- Conditions
- Dry Eye, Sjogren's Syndrome, Graft vs. Host Disease
- Trial name
- NCT01393132
- Testing
- Thymosin Beta 4 eye drops, Vehicle Control
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Michigan Cornea Consultants, PC
Dry Eye Syndrome
Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment
The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT04343287
- Testing
- BRM421
- Where
- 4 sites in United States
- Volunteers
- 220 people
- Sponsor
- BRIM Biotechnology Inc.
Sjogren's Syndrome, Dry Eye
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
The objective of the present study was to evaluate the efficacy of autologous serum tears combined with 0.05% cyclosporin eye drop in treating Sjögren's syndrome dry eye and their effect on corneal nerves.
- Conditions
- Sjogren's Syndrome, Dry Eye, Ocular Surface Disease
- Trial name
- AST/SS (NCT06013436)
- Testing
- Autologous serum tears combined with 0.05% cyclosporin eye drop
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Dry Eye, Dry Eye Disease
PMCF Study to Evaluate Performance and Safety of "HPMC-based Eyedrops" Used to Relieve Dry Eye Symptoms
Dry eye disease (DED), also called keratoconjunctivitis sicca, is a common ocular condition characterized by a loss of homeostasis of the tear film and inflammation of the ocular surface.
- Conditions
- Dry Eye, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Trial name
- NCT05825599
- Testing
- Hydroxypropyl methylcellulose eye drops
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- C.O.C. Farmaceutici S.r.l.
Dry Eye Syndrome
Changes in Tear Osmolarity Over Time With Sustained Use of TheraTears
The objective of the study is to see if there is a change in tear osmolarity over time when moderate to severe dry eye subjects are treated with TheraTears® lubricating drops.
- Trial name
- BENTLEY (NCT02100787)
- Testing
- TheraTears lubricating drops
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Jenkins Eye Care
Dry Eye
Management of DE With IPL in Combination With DQS
Intense pulsed light (IPL) has been reported to improve signs and symptoms of dry eye (DE). Additionally, meibomian gland secretion of lipids has been observed to improve through the use of IPL.
- Trial name
- NCT05694026
- Testing
- Intense pulsed light, Diquafosol tetrasodium
- Where
- China
- Volunteers
- 360 people
- Sponsor
- He Eye Hospital
Dry Eye
A Study to Evaluate the Effect of Miebo™ on Preoperative Biometry/Keratometry and Postoperative Refractive Accuracy
A Phase 4, Multicenter, Open-Label Study to Evaluate the Effect of Miebo™ on Preoperative Biometry/ Keratometry and Postoperative Refractive Accuracy
- Trial name
- NCT06346340
- Testing
- Miebo
- Where
- 12 sites in United States
- Volunteers
- 97 people
- Sponsor
- Bausch & Lomb Incorporated
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