Clinical trials: Dry Eye, completed
Dry Eye Disease
IVW-1001 Phase 1/2 in Subjects With Dry Eye Disease
Double-masked, dose-response, trial of IVW-1001 in subjects with dry eye disease.
- Trial name
- NCT06400459
- Testing
- IVW-1001 Ophthalmic Eyelid Wipe 0.1%, IVW-1001 Ophthalmic Eyelid Wipe 0.2%
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- IVIEW Therapeutics Inc.
Dry Eye, Dry Eye Disease (DED)
A Study in the Treatment of Mild to Moderate Dry Eye Disease Comparing Saline to TTAX03.
The purpose of this randomized, controlled, multicenter study is to evaluate the safety and efficacy of TTAX03 in participants with mild to moderate DED. The primary question it aims to answer is if TTAX03 is safe.
- Conditions
- Dry Eye, Dry Eye Disease (DED), Dry Eye Disease With Severe Keratitis
- Trial name
- NCT06780306
- Testing
- TTAX03
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- BioTissue Holdings, Inc
Dry Eye Disease
A Study Designed to Evaluate Tear Production
The purpose of this study is to evaluate tear production following acute administration of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) in subjects with dry eye disease (DED).
- Trial name
- NCT06544707
- Testing
- 0.003% AR-15512 ophthalmic solution
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research
Dry Eye Syndromes, Meibomian Gland Dysfunction
Mechanisms of Light-based Therapies for Dry Eye Disease
Dry eye disease is a common condition affecting millions worldwide and costing millions in healthcare due to reduced work productivity and quality of life.
- Trial name
- MOLT (NCT06004895)
- Testing
- Actual IPL, LLLT
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Aston University
Sjogren Syndrome
Biopsy Based Study to Understand Mechanism of Action of Ianalumab in Salivary Glands and Explore Relationships With Clinical Assessments.
This study aims at elucidating the mechanism of action of ianalumab in salivary glands and explore relationships with clinical assessments
- Trial name
- NCT05124925
- Testing
- Ianalumab
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes
Non Interventional Study to Evaluate the Efficacy and Tolerability of Ectoin Containing Ophthalmic Solution
This is a comparative, open label, parallel group, non interventional study to further demonstrate the efficacy and tolerability of BAT04. In addition the efficacy and safety shall be compared to Hyaluronic acid (HA)-Product.
- Trial name
- NCT01684852
- Testing
- Medical device, drug-like
- Where
- 5 sites in Germany
- Volunteers
- 64 people
- Sponsor
- Bitop AG
Dry Eye
Performance and Safety of T2769 in DED
To demonstrate the non-inferiority of T2769 compared to Vismed® Multi in terms of total ocular surface staining (Oxford score) after 35 days of treatment. To evaluate the performance and safety of T2769 versus Vismed® Multi.
- Trial name
- NCT05965778
- Testing
- T2769, Vismed® Multi
- Where
- France
- Volunteers
- 251 people
- Sponsor
- Laboratoires Thea
Dry Eye Disease
A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye
The purpose of this study is to evaluate the efficacy and safety of SI-614 ophthalmic solution compared with placebo in patients with dry eye
- Trial name
- SIDE (NCT05411367)
- Testing
- SI-614
- Where
- 6 sites in United States
- Volunteers
- 232 people
- Sponsor
- Seikagaku Corporation
Dry Eye Syndromes
Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel
Objective: To assess the safety and tolerability of the PRO-165 formulation on the ocular surface of ophthalmologically and clinically healthy subjects.
- Trial name
- PRO-165 (NCT03697876)
- Testing
- PRO-165, Artelac
- Where
- Mexico
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye, Dry Eye After LASIK-Laser in Situ Keratomileusis
Combined Treatment With Pulsed Light and Photobiomodulation Before Laser Refractive Surgery
Laser corneal refractive surgery is a widely adopted approach for correcting refractive errors, but postoperative dry eye remains a common side effect.
- Trial name
- TEBELID (NCT05803798)
- Testing
- IPL+LLLT
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Dry Eye, Dry Eye Syndromes
Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction
The modern treatment of meibomian gland dysfunction(MGD) is based on anti-inflammatory drops or oral antibiotics for decreasing dry eye disease (DED) associated inflammation, warm compresses for liquefying the thicker meibum, and…
- Conditions
- Dry Eye, Dry Eye Syndromes, Meibomian Gland Dysfunction
- Trial name
- NCT04425551
- Testing
- laser light
- Where
- 2 sites in Greece
- Volunteers
- 30 people
- Sponsor
- Naval Hospital, Athens
Dry Eye Syndrome
Performance and Safety of T2769 Versus Hylo-Forte® in the Treatment of Moderate to Severe Dry Eye Syndrome.
The objective is to demonstrate the non-inferiority of T2769 compared to Hylo-Forte® in terms of the change from baseline (D1) in total ocular surface staining score assessed on Oxford 0-15 scale, in the study eye at the D36…
- Trial name
- NCT06375499
- Testing
- T2769, Hylo-Forte®
- Where
- 4 sites in Czechia, Hungary
- Volunteers
- 74 people
- Sponsor
- Laboratoires Thea
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery
This randomized, controlled clinical trial investigates the perioperative use of low-level light therapy (LLLT) to prevent or reduce signs and symptoms of dry eye disease (DED) in patients undergoing cataract surgery.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease
- Trial name
- LLLT-Cataract (NCT07067294)
- Testing
- Low-Level Light Therapy
- Where
- Romania
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Dry Eye Disease
A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
A Randomized, Double-Masked, Vehicle-Controlled Parallel Group Clinical Trial to Assess Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects with Dry Eye Disease
- Trial name
- NCT06493604
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye Disease (DED)
Immediate Therapeutic Effects of Diquafosol and Rebamipide in Dry Eye Disease
This study compares the immediate therapeutic and mucin-secreting effects 30 minutes after instillation of 3% diquafosol and 2% rebamipide in dry eye disease.
- Trial name
- NCT07297316
- Testing
- 3% diquafosol (right eye) and 2% rebamipide (left eye), 2% rebamipide (right eye) and 3% diquafosol (left eye)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Dry Eye
A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear
Assess the impact of concomitant Miebo use while wearing contact lenses
- Trial name
- NCT07054606
- Testing
- Perfluorohexyloctane ophthalmic solution
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Bausch & Lomb Incorporated
Sjogren's Syndrome, Keratoconjunctivitis Sicca
Levocarnitine for Dry Eye in Sjogren's Syndrome
This study evaluates the effectiveness of levocarnitine in the treatment of dry eye in adults with Sjogren's syndrome. This will be a crossover study design with all participants receiving both levocarnitine and placebo.
- Trial name
- NCT03953703
- Testing
- Levocarnitine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University Medical Center
Dry Eye, Contact Lens Complication
Total30 For Contact Lens Dropouts
Contact lens (CL) discomfort is a complex phenomenon that has been defined by the Tear Film and Ocular Surface Society (TFOS) in their seminal report on CL discomfort as a condition that results in "episodic or persistent adverse…
- Conditions
- Dry Eye, Contact Lens Complication, Contact Lenses
- Trial name
- T30DO (NCT06967298)
- Testing
- T30 Contact lenses
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Southern College of Optometry
Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of 0.25% Reproxalap Ophthalmic Solution in Subjects with Dry Eye Disease
- Trial name
- NCT04735393
- Testing
- Reproxalap Ophthalmic Solution (0.25%)
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye Disease
Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease
Primary Objectives: To compare the efficacy of cenegermin vs vehicle in Schirmer I test (without anaesthesia) > 10 mm/5 min at Week 4 by testing the superiority.
- Trial name
- PROTEGO-2 (NCT05136170)
- Testing
- Cenegermin, Vehicle
- Where
- 10 sites in United States, Italy
- Volunteers
- 85 people
- Sponsor
- Dompé Farmaceutici S.p.A