Clinical trials: Dry Eye Disease
Sjögren's Syndrome
Efficacy and Safety of Belimumab in Subjects With Primary Sjögren's Syndrome
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by an increase in BAFF (BLyS) levels and a resulting B cell hyperactivity.
- Trial name
- BELISS (NCT01160666)
- Testing
- Belimumab
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Eye
RPS InflammaDry Detector™ to Determine MMP-9 Levels in Tears
The RPS InflammaDry Detector™ is intended to detect elevated MMP-9 in human tears to aid in the diagnosis of patients with signs or symptoms of dry eye disease, in conjunction with other methods of clinical evaluation.
- Trial name
- NCT01313351
- Testing
- RPS InflammaDry Detector™
- Where
- 8 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening
Autoimmune Diseases, Autoinflammatory Diseases
Observational Study of Pediatric Rheumatic and Immunologic Diseases in China: The CAPRID Registry
An observational, multi-center, longitudinal registry study for Chinese pediatric patients with rheumatic and immunologic diseases.
- Trial name
- NCT06417502
- Where
- 9 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking Union Medical College Hospital
Dry Eye, Visual Acuity
Treating Lid Wiper Epitheliopathy
Lid wiper epitheliopathy (LWE) is a relatively new entry into the abundance of clinical ocular surface health signs. LWE was first reported in 2002 as a potential cause for dry eye disease (DED) (Korb et al., 2002).
- Trial name
- TLWE (NCT06671041)
- Testing
- Preservative Free eye drop
- Where
- 4 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Southern College of Optometry
Mild to Moderate Dry Eye Disease
A Study to Evaluate the Safety and Effectiveness of Restylane-Defyne for Punctual Occlusion
A study which participants with mild to moderate dry eye disease will have a punctum of one eye injected with Restyalne Defyne and the other eye injected with saline solution. Participants will be evaluated over four visits.
- Trial name
- NCT03709641
- Testing
- Restylane Defyne
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- John C Meyer, MD
Dry Eye Syndrome
Assessing the Safety and Efficacy of AVX-012 in Subjects With Mild-to-moderate Dry Eye Syndrome
This is a first-in-human phase I/II randomized, double-blind, placebo (vehicle)-controlled, multicenter study to assess the Safety and Efficacy of AVX-012 Ophthalmic Solution in subjects with Mild-to-Moderate Dry Eye Syndrome.
- Trial name
- AVX012CT001 (NCT03162094)
- Testing
- AVX012 Ophthalmic Solution Low dose, AVX012 Ophthalmic Solution High dose
- Where
- 21 sites in Spain
- Volunteers
- 172 people
- Sponsor
- Avizorex Pharma, S.L.
Dry Eye
Clinical Outcomes Following Treatment With SYSTANE® BALANCE
The purpose of this study is to evaluate the clinical effectiveness of SYSTANE® BALANCE compared to REFRESH OPTIVE® Advanced in subjects with lipid-deficient dry eye.
- Trial name
- NCT02776670
- Testing
- Propylene glycol, 0.6% eye drops, Lubricant eye drops
- Volunteers
- 308 people
- Sponsor
- Alcon Research
Cataract, Dry Eye Disease
The Influence of PRN Omega-3 Nutritional Supplement on Visual Acuity
This is a randomized, masked, placebo controlled study to assess the effect on visual acuity, if any, of the PRN omega-3 nutritional supplement in subjects undergoing cataract surgery.
- Trial name
- NCT02260973
- Testing
- Omega-3 (Triglyceride form)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Physician Recommended Nutriceuticals
Sjogren's Syndrome
Implantology and Sjögren's Syndrome
Until now it has not been investigated whether placement of implants in SS patients is less successful than compared to non-SS patients.
- Trial name
- NCT02661243
- Testing
- Biohorizons Laser-lok bonelevel dental implants
- Where
- 5 sites in Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Derk Jan Jager
Dry Eye Syndromes, Pterygium
Assessment of the Efficacy of Ocular Dipyridamole in the Treatment of Dry Eye Symptomology in Subjects With Pterygium
Subjects with pterygium and associated dry eye symptoms (DES) are randomized into an active cohort (receiving ocular administration of Dipyridamole) or placebo cohort (ocular administration of vehicle).
- Trial name
- NCT02782260
- Testing
- Dipyridamole
- Volunteers
- 40 people
- Sponsor
- Ariel University
Dry Eye Disease (DED), MGD-Meibomian Gland Dysfunction
The Effect of Eyelid Support Plate Assisted Eyelid Massage on Meibomian Gland Dysfunction: a Randomized Controlled Trial
This study aims to conduct a randomized controlled clinical trial to compare the efficacy of a new type of massage device - eyelid support plate and glass rod assisted eyelid massage in improving MGD related dry eye symptoms, and…
- Trial name
- NCT07633938
- Testing
- eyelid support plate assisted eyelid massage, glass rod assisted eyelid massage
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye Syndromes
Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease
This study will investigate the safety, efficacy and acceptability of two new eye drop formulations compared with Refresh Tears® in patients with dry eye disease.
- Trial name
- NCT01294384
- Testing
- carboxymethylcellulose sodium based New Eye Drop Formulation 1, carboxymethylcellulose sodium based New Eye Drop Formulation 2, carboxymethylcellulose sodium based Eye Drops
- Where
- 2 sites in Australia, Canada
- Volunteers
- 305 people
- Sponsor
- Allergan
Rheumatoid Arthritis, Systemic Lupus Erythematosus
A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body
This first-in-human study evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of HBM7020.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis, Sjögren's Disease
- Trial name
- NCT07649265
- Testing
- HBM7020
- Where
- Australia
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Dry Eye, Dry Eye Syndromes
Effect of Lifitegrast 5% on Tear Film Markers
The purpose of this study is to assess the duration of time (in weeks) for improvement in objective dry eye markers for people who are placed on lifitegrast 0.5% (Xiidra®), an FDA-approved therapy for dry eyes.
- Conditions
- Dry Eye, Dry Eye Syndromes, Dry Eyes Chronic
- Trial name
- NCT03952481
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Myopia, Dry Eye
Effect of Contact Lenses on Tear Osmolarity in a Controlled Low Humidity Chamber
The purpose of this study is to evaluate two different types of contact lenses and their effect on dry eyes when compared to wearing glasses in a controlled, low humidity chamber.
- Trial name
- NCT01482312
- Testing
- lotrafilcon A contact lenses, comfilcon A contact lenses, Glasses
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- CIBA VISION
Sjogren's Syndrome, Fatigue
Fatigue in Primary Sjögren's Syndrome
Fatigue is a common clinical finding in Primary Sjögren's syndrome (PSS). In PSS, there is not enough data about the conditions in which fatigue develops and which clinical conditions the disease is associated with.
- Conditions
- Sjogren's Syndrome, Fatigue, Pain Syndrome, Depression
- Trial name
- NCT04802577
- Testing
- FACT-F questionnaire, Beck Depression Inventory, Beck Anxiety Inventory
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Pulmonary Arterial Hypertension, HIV Infection
Auto-immunity and Pulmonary Arterial Hypertension
The investigators have recently evidenced the presence of antibodies to endothelial cells and fibroblasts in patients with idiopathic or SSc-associated PAH.
- Conditions
- Pulmonary Arterial Hypertension, HIV Infection, Congenital Heart Defect, Systemic Sclerosis
- Trial name
- Auto-HTAP (NCT01208792)
- Testing
- skin biopsy, Blood Sample
- Where
- 3 sites in France
- Volunteers
- 629 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Eye Syndromes
Goblet Cell Degranulation Produced by Intranasal Tear Neurostimulator (ITN) in Dry Eye Disease
The purpose of this study is to evaluate goblet cell degranulation following acute use of the Intranasal Tear Neurostimulator in participants with dry eye.
- Trial name
- NCT03827564
- Testing
- Intranasal Tear Neurostimulator (ITN) [TrueTear®]
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Allergan
Eye Dryness
Clinical Trial for the Evaluation of Safety and Efficacy of Drop 0.4%
The aim of the trial is to compare the safety and efficacy of the moisturizing solution DROP 0.4% with the moisturizing solution AVIZOR EYE DROPS 0.2% PRESERVED in relieving the symptoms of dry eye over one month of use.
- Trial name
- DROP04 (NCT06985875)
- Testing
- Multidose mosturizing solution DROP 0.4%, Multidose mosturizing solution Avizor Eye Drops 0.2% Preserved
- Volunteers
- 79 people
- Sponsor
- Avizor SA
Polycystic Ovary Syndrome, Dry Eye
PCOS and Problem of Eye Dryness: Is There a Benefit From Lifetyle Changes
Women with polycystic ovarian syndrome (PCOS) may complain dryness of their eyes especially obese ones. lifestye changes are main treatrment fro both problems
- Conditions
- Polycystic Ovary Syndrome, Dry Eye, Obesity
- Trial name
- NCT07366944
- Testing
- exercise and limiting diet, diet limitation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University