Clinical trials: Dry Eye Disease
Dry Eye Disease
A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye
The purpose of this study is to evaluate the efficacy and safety of SI-614 ophthalmic solution compared with placebo in patients with dry eye
- Trial name
- SIDE (NCT05411367)
- Testing
- SI-614
- Where
- 6 sites in United States
- Volunteers
- 232 people
- Sponsor
- Seikagaku Corporation
Dry Eye Syndromes
Efficacy and Acceptability of Two Lubricant Eye Drops
Efficacy and acceptability of two new artificial tears following two weeks of treatment in patients with dry eye. Patients will be randomized to 1 of 2 treatments for 7 days then crossover to the alternate treatment for 7 days.
- Trial name
- NCT00756678
- Testing
- Lubricant Eye Drops (Optive™), Lubricating Eye Drops (blink® Tears)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Allergan
Dry Eye Syndrome
Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV)
Efficacy and Safety of the Ophthalmic Solution PRO-087 versus Systane ® Ultra and Systane ® Ultra Preservative Free on the Tear Film Dysfunction Syndrome from Mild to Moderate Clinical trial To evaluate the effectiveness of…
- Trial name
- 087LATAMFIV (NCT03223909)
- Testing
- PRO-087, Systane Ultra, Systane Ultra Preservative Free
- Where
- Mexico
- Volunteers
- 326 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Keratoconjunctivitis Sicca, Dry Eye Disease
Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)
The purpose of the study is to evaluate the efficacy of SAR 1118 Ophthalmic Solution (5.0%) compared to placebo in the treatment of Dry Eye.
- Trial name
- OPUS-1 (NCT01421498)
- Testing
- Lifitegrast
- Where
- 13 sites in United States
- Volunteers
- 588 people
- Sponsor
- Shire
Dry Eye
Investigating iLux Efficacy in Contact Lens Wearers With Evaporative Dry Eye Disease
The purpose of this clinical trial is to investigate the efficacy of a single iLux® treatment in symptomatic CL wearers who have DED (according to the TFOS DEWS II diagnostic criteria), of the evaporative dry eye disease subtype…
- Trial name
- SHEEPDOG (NCT04159935)
- Testing
- iLux® system
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye Syndromes
Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy
This study will evaluate the safety and efficacy of cyclosporine 0.05% ophthalmic emulsion (Restasis®) in patients with dry eye disease.
- Trial name
- IMPACT (NCT02121847)
- Testing
- cyclosporine 0.05% ophthalmic emulsion, carboxymethylcellulose-based lubricant eye drops
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Allergan
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Syndromes
Dose-response Study of OPC-12759 Ophthalmic Suspension
The purpose of this study is to evaluate the dose-response of OPC-12759 ophthalmic suspension in dry eye patients.
- Trial name
- NCT00234078
- Testing
- 0.5% OPC-12759, 1% OPC-12759, 2% OPC-12759
- Where
- Japan
- Volunteers
- 290 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Age-Related Macular Degeneration
Safety and Efficacy Study of OpRegen for Treatment of Advanced Dry-Form Age-Related Macular Degeneration
The main objective of the study is evaluation of the safety and tolerability of OpRegen - Human embryonic stem cell-derived retinal pigment epithelial (RPE) cells.
- Trial name
- NCT02286089
- Testing
- OpRegen
- Where
- 7 sites in United States, Israel
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
Keratoconjunctivitis Sicca
Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca
This is a randomized, double-masked, vehicle-controlled study of the safety and efficacy of OTX-101 (0.09% cyclosporine nanomicellar solution) in the treatment of keratoconjunctivitis sicca to be conducted at approximately 50…
- Trial name
- Emerald (NCT02688556)
- Testing
- cyclosporine, vehicle of OTX-101
- Where
- 3 sites in United States
- Volunteers
- 745 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Chalazion, Dry Eye Syndromes
Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye
The objective of this study is to evaluate the clinical utility, safety and effectiveness of the Manual Mini System compared to standardized warm compress therapy for application of controlled, localized heat therapy in adult…
- Trial name
- NCT00832130
- Testing
- Manual Mini System, iHeat Portable Warm Compress Therapy
- Where
- 11 sites in United States
- Volunteers
- 139 people
- Sponsor
- TearScience, Inc.
Dry Eye Disease
A Long-Term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512
The purpose of this study is to evaluate the safety of topical ophthalmic 0.003% AR-15512 compared to its vehicle dosed twice daily (BID) in subjects with dry eye disease (DED) for 12 months.
- Trial name
- COMET-4 (NCT05493111)
- Testing
- 0.003% AR-15512 ophthalmic solution, AR-15512 vehicle ophthalmic solution
- Where
- 10 sites in United States
- Volunteers
- 275 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye, Dry Eye Syndromes
Tear Production by Nasal Neurostimulation Compared to Active Control
This crossover design study evaluates the effectiveness of the Oculeve Intranasal Neurostimulator comparing the effect of intranasal (active) versus extranasal (control) stimulation on tear production as measured by the Jones…
- Conditions
- Dry Eye, Dry Eye Syndromes, Keratoconjunctivitis Sicca
- Trial name
- NCT02970799
- Testing
- Intranasal Neurostimulator
- Volunteers
- 27 people
- Sponsor
- Oculeve, Inc.
Dry Eye
Evaluation of SYSTANE Ultra Lubricant Eye Drops
To evaluate the safety and efficacy of two artificial tears in dry eye patients.
- Trial name
- NCT00702377
- Testing
- SYSTANE Ultra, Optive
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Alcon Research
Dry Eye Syndromes
Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation
The objectives of this study are: To compare the change in levels of tear proteins and inflammatory mediators pre and post administration between the intranasal and extranasal applications To compare the goblet cell count…
- Trial name
- NCT02385292
- Testing
- Oculeve Intranasal Lacrimal Neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Oculeve, Inc.
Dry Eye
The Effect of Systane Ultra Lubricant Eye Drops (FID 112903) on Visual Performance
To evaluate the effect of 2 different lubricant eye drops on visual function of patients with dry eye
- Trial name
- NCT00673764
- Testing
- Systane Ultra Lubricant Eye Drops, Optive Lubricant Eye Drops
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Alcon Research
Dry Eye Disease
A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
The purpose of this study is to evaluate the effect of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) on ocular surface characteristics of subjects with dry eye disease (DED).
- Trial name
- NCT06544694
- Testing
- 0.003% AR-15512 ophthalmic solution, Artificial Tears
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Alcon Research
Dry Eye, Neuropathic Eye Pain
Azithromycin for Meibomian Gland Disease
This study aims to elucidate the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction.
- Conditions
- Dry Eye, Neuropathic Eye Pain, Ocular Microbiome, Depression, Anxiety
- Trial name
- NCT03953118
- Testing
- Azithromycin Oral Product
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Macular Degeneration
Alprostadil in Maculopathy Study (AIMS)
Evaluation of efficacy of alprostadil (prostaglandin E1) for treatment of patients suffering from dry age-related macula degeneration
- Trial name
- NCT00619229
- Testing
- Alprostadil (prostaglandin E1)
- Where
- 6 sites in Germany
- Volunteers
- 37 people
- Sponsor
- UCB Pharma
Sjögren's Syndrome
Proof of Concept Study to Evaluate the Efficacy and Safety of BMS-931699 (Lulizumab) or BMS-986142 in Primary Sjögren's Syndrome
The primary objective of this study is to evaluate the efficacy of treatment with either lulizumab or BMS-986142 versus placebo in subjects with moderate to severe primary Sjögren's syndrome as measured by the change from…
- Trial name
- NCT02843659
- Testing
- BMS-931699, BMS-986142
- Where
- 34 sites in United States, Australia and 9 more
- Volunteers
- 45 people
- Sponsor
- Bristol-Myers Squibb