Clinical trials: Dry Eye Disease (DED), open to volunteers
Dry Eye Disease (DED)
The Effects of 3% Trehalose Ophthalmic Solution on Corneal Epithelial Barrier Function
The purpose of this research study is to evaluate the effects of trehalose, an ingredient found in commercially available artificial tears, on the corneal barrier function.
- Trial name
- NCT06655441
- Testing
- 3% trehalose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Southern California College of Optometry at Marshall B. Ketchum University
Dry Eye Disease (DED)
The Effect of 0.1% Topical Ciclosporin A for 12-weeks on the Eye Surface Immune Cells in Dry Eyes
Dry eye disease (DED) is a common, long-lasting condition that affects the surface of the eye. It happens when there's a problem with tear production or quality, which can lead to inflammation and discomfort.
- Trial name
- NCT06898853
- Testing
- 0.1% Ciclosporin A eye drops, Mineral oils eye drops
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- The University of New South Wales
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Dry Eye Disease (DED)
Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial
The goal of this clinical trial is to compare the effect of behavioral intervention (Baduanjin alone or laughter exercise plus artificial tears) versus artificial tears in patients with dry eye disease.
- Trial name
- NCT07524725
- Testing
- Baduanjin, Laughter exercise, Artificial tears
- Volunteers
- 540 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye Disease (DED), Cataract (Post-operative Cataract Surgery Follow-up)
Effect of Dry Eye Disease on Accuracy of Intraocular Lens Power Calculation Before Phacoemulsification
This study aims to determine the effect of dry eye disease on intraocular lens power calculation and the postoperative refractive outcome.
- Trial name
- NCT07525336
- Testing
- dry eye disease optimization
- Volunteers
- 100 people
- Sponsor
- Assiut University
Dry Eye Syndromes, Dry Eye Disease (DED)
Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DED
The goal of this clinical investigation plan is to evaluate the performance, tolerability, safety, and compliance of an ophthalmic solution containing an ancillary medicinal substance and hyaluronic acid 0.3% (FBV_01) compared…
- Trial name
- NCT07412860
- Testing
- FBV_01, HYLO-VISION® SafeDrop® Gel
- Where
- 2 sites in Italy
- Volunteers
- 74 people
- Sponsor
- FB Vision S.p.A
Juvenile Open Angle Glaucoma, Dry Eye Disease (DED)
Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients.
- Conditions
- Juvenile Open Angle Glaucoma, Dry Eye Disease (DED), Interleukin 6, Retinal Nerve Fiber Layer Thickness
- Trial name
- HONEY-JOAG (NCT07396441)
- Testing
- Stingless bee honey (Kelulut)
- Where
- 4 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Dry Eye Disease (DED), Cataract
Rebamipide Versus Diquafosol for Perioperative Dry Eye in Cataract Surgery
This clinical trial is designed to compare two commonly used eye drop treatments for dry eye disease in patients undergoing cataract surgery.
- Trial name
- NCT07397949
- Testing
- Rebamipide 2% ophthalmic solution, Diquafosol 3% ophthalmic solution
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Dry Eye Disease (DED) , Diabetic Macular Edema
Association Between Dry Eye Disease and Diabetic Macular Edema
This study evaluates the association between dry eye disease (DED) and diabetic macular edema (DME) in adult patients at the Ophthalmology Department, Faculty of Medicine, Sohag University.
- Trial name
- DED-DME (NCT07392307)
- Testing
- Dry Eye Disease Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Dry Eye Disease (DED)
Efficacy and Safety of VMX Eye Drops for Dry Eye Disease
This multicenter, randomized, double-blind study evaluates the safety and effectiveness of VMX eye drops in patients with dry eye disease.
- Trial name
- NCT07369375
- Testing
- VMX Eye Drops
- Volunteers
- 76 people
- Sponsor
- VISUfarma SpA
Dry Eye Disease (DED)
Impact of Tixel Treatment on Symptoms and Signs in Patients With Dry Eye Disease
This study will examine how a standard Tixel treatment versus a sham treatment for eye wrinkles affects the symptoms and signs of Dry Eye Disease.
- Trial name
- TIXEL-DED (NCT06615453)
- Testing
- Thermo-mechanical action based peri-orbital fractional skin treatment
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Aston University
Dry Eye, Dry Eye Disease (DED)
Telemedicine for Evaluating Dry Eye Disease (DED) Using a Mobile Phone-Attached Portable Automatic Ocular Surface Imaging Device (PAOSID): A Patient-Operated Diagnostic and Continuous Ocular Surface Monitoring (COSM) System
Dry eye disease (DED) is a common eye condition that is becoming more widespread. Detecting it early, keeping track of its progression, and following up regularly can help protect vision and prevent serious complications.
- Trial name
- NCT07341724
- Testing
- Dr Eye
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Dry Eye Disease (DED), Graves Ophthalmopathy
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients With Graves Disease
This prospective, interventional, randomized, controlled, double-blind clinical study evaluates the effect of Low-Level Light Therapy (LLLT) delivered by a polychromatic periocular mask (Eye-light®️) versus a sham device in…
- Trial name
- LLLT-Graves (NCT07332988)
- Testing
- Low Light Level therapy
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Dry Eye Disease (DED)
Investigator Initiated Trial Using Dry Eye Surveys to Evaluate and Better Understand FDA Approved Acoltremon Treatment for Dry Eye Disease in Real World Treatment Settings (DESERT)
Dry eye disease (DED) is a common, chronic and multifactorial disease of the ocular surface presenting with signs and symptoms of ocular discomfort, visual disturbance and fluctuation, tear film instability, ocular surface…
- Trial name
- (DESERT) (NCT07281950)
- Testing
- acoltremon 0.003%
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Center for Sight Las Vegas
Dry Eye Disease (DED), Dry Eye Syndrome (DES)
Safety and Efficacy of Kelulut Honey Eyedrops in Dry Eye Disease
The goal of this clinical trial is to learn whether Kelulut honey eyedrops are safe and helpful in treating dry eye disease in adults.
- Conditions
- Dry Eye Disease (DED), Dry Eye Syndrome (DES), Dry Eye Symptoms
- Trial name
- NCT07279324
- Testing
- Kelulut Honey Eyedrop 12.5%, Kelulut Honey Eyedrop 25%, Kelulut Honey Eyedrop 50%
- Where
- Malaysia
- Volunteers
- 45 people
- Sponsor
- Universiti Sains Malaysia
Dry Eye Disease (DED)
Moderate-to-Severe Dry Eye Disease Relief Using Acoltremon
To evaluate the impact of Acoltremon 0.003% on subjective dry eye symptoms using validated patient-reported outcome measures: Eye Dryness Score Visual Analog Scale (EDS-VAS).
- Trial name
- ASTRA (NCT07268599)
- Testing
- Acoltremon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Colvard Kandavel Eye Center
Dry Eye Disease (DED), Keratoconjunctivitis Sicca
A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease
To evaluate the safety and efficacy of BRM421 Ophthalmic Solution compared to artificial tear for treatment of the signs and symptoms of dry eye disease (DED)
- Trial name
- NCT07078955
- Testing
- BRM421 Ophthalmic Solution, 0.03%, Artificial Tear, BRM421 Ophthalmic Solution, 0.06%
- Where
- Taiwan
- Volunteers
- 99 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye Disease (DED)
Evaluating Crosslinked Hyaluronate Canalicular Gel for the Treatment of DED in Patients Undergoing Cataract Surgery
To review how patients report using a hyaluronate crosslinked canalicular gel placed before cataract surgery
- Trial name
- LaReCa (NCT07155057)
- Testing
- Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Dry Eye Disease (DED)
A Study Evaluating the Efficacy and Safety of RCI001 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye
The objective of this study is to evaluate the safety and efficacy of 0.25% RCI001 Ophthalmic Solution twice a day (BID) and four times a day (QID) compared to placebo (vehicle) in the treatment of the signs and symptoms of dry…
- Trial name
- NCT07068958
- Testing
- 0.25% RCI001 Ophthalmic Solution
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Dry Eye Disease (DED)
Correlation of Dry Eye Disease, Problematic Smartphone Use and Sleep Quality in Adolescents and Young Adults
The goal of this observational study is to learn about the status quo and relationship of dry eye, problematic smartphone use, bedtime procrastination, and sleep in adolescents and young adults.
- Trial name
- NCT07020871
- Where
- China
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD