Clinical trials: Dry Eye Disease (DED), open to volunteers
Dry Eye Disease (DED)
An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease
This is a Phase 2, randomized, multicenter, double masked, vehicle controlled, parallel group study to evaluate the efficacy and safety of DFL24498 topical ophthalmic solution versus vehicle in participants with dry eye disease.
- Trial name
- NCT07503886
- Testing
- DFL24498, Vehicle
- Where
- 24 sites in United States
- Volunteers
- 417 people
- Sponsor
- Dompé Farmaceutici S.p.A
DED, Aqueous-deficient Dry Eye Disease
Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.
This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.
- Trial name
- NCT07571330
- Testing
- Punctal plug occlusion
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Periodontitis, Dry Eye Disease (DED)
Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study
This study is aiming at exploring the association between periodontitis and dry eye disease, which are both chronic inflammatory diseases that might have common pathogenic mechanisms.
- Trial name
- NCT07873697
- Where
- Iraq
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sulaimani
Myopia, Dry Eye Disease (DED)
Study of Eye Fatigue From Digital Screens and Its Impact on Visual Performance in People With Normal Vision and Myopia, With and Without Dry Eye Symptoms and Signs
The goal of this observational study is to investigate the effects of eye fatigue induced by screen task on dry eye disease (DED) signs and symptoms, visual performance, and visual behavior in young adults with and without DED…
- Trial name
- RReye (NCT07844408)
- Testing
- Eye Exams, Ocular Biometry and Aberrometry, Wearing a Smartwatch
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Essilor International
Dry Eye Disease (DED)
BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber
The purpose of this study is to evaluate the short-term effects (impact on tear film and dry eye symptoms) of the BriTer Eyez Moisture Vue™ On-Demand Disposable Moisture Chamber (the device under investigation) in individuals…
- Trial name
- NCT07430735
- Testing
- BriTer Eyez Moisture Vue™ On Demand Disposable Moisture Chamber
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Rochester
Dry Eye, Dry Eye Disease (DED)
Temporary Tear Duct Filling With Hyaluronic Acid Gel and Assessment of Dry Eye Disease (DED) After Bilateral Cataract Surgery
Dry eye disease can occur or worsen after cataract surgery and may cause ocular discomfort and reduced visual quality. Standard treatment commonly includes artificial tear eye drops, which provide temporary lubrication.
- Conditions
- Dry Eye, Dry Eye Disease (DED), Dry Eye Sensation After Cataract Surgery
- Trial name
- TANAMI (NCT07809022)
- Testing
- LACRIFILL® Canalicular Gel administration
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University of Vienna
Dry Eye Disease (DED), Graft-Versus-Host Disease(GVHD)
Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments
This Phase IIB, multicenter, double-blind, randomized, and uncontrolled clinical trial aims to assess the efficacy and safety of subconjunctival injection of Mesenchymal Stem Cells (MSCs) in patients with Graft-versus-Host…
- Trial name
- TER-EYE (NCT06905834)
- Testing
- Subconjuntival injection of expanded allogenic adult adipose tissue-derived mesenchymal stem cells (ASC
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
Dry Eye Disease (DED)
A Clinical Study Evaluating Licaminlimab for Dry Eye Disease
The primary objective of this study is to evaluate the efficacy and safety of the topical ophthalmic administration of licaminlimab as compared to vehicle in participants with Dry Eye Disease and a specific genotype.
- Trial name
- PREDICT-1 (NCT07548632)
- Testing
- Artificial Tear Run-in, licaminlimab, Vehicle of licaminlimab
- Where
- 14 sites in United States
- Volunteers
- 160 people
- Sponsor
- Oculis
Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG)
A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.
- Conditions
- Fuchs Endothelial Corneal Dysfunction, Open Angle Glaucoma (OAG), Dry Eye Disease (DED), Keratoconus
- Trial name
- NCT07780890
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Dry Eye Disease (DED), Cataract Surgery
POST CATARACT SURGERY DRY EYE DISEASE
Cataract surgery is one of the most frequent and successful interventions currently undertaken in medicine. However, a significant number of patients who underwent cataract surgery still complain about postoperative symptoms…
- Trial name
- NCT07715266
- Testing
- NOX-01
- Where
- 2 sites in Spain
- Volunteers
- 33 people
- Sponsor
- NOXELIS
Dry Eye Disease (DED)
The Effectiveness of Systane PRO Preservative Free Verses Blink Triple Care Preservative Free
The goal of this investigational study is to determine if Systane PRO Preservative Free is non-inferior to BLINK TRIPLE CARE in the clinically significant improvement of signs and symptoms of dry eye in patients over 4 weeks.
- Trial name
- SYSTANEvBLINK (NCT07745062)
- Testing
- Systane PRO, Blink tears
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Gordon Schanzlin New Vision
Dry Eye Disease (DED)
TRYPTYR as a Treatment for Patients With Dry Eye Disease (DED)
The purpose of this research study is to determine the effectiveness of TRYPTYR as a treatment for Dry Eye Disease. The primary efficacy variable is change from baseline in the Ocular Surface Disease Index (OSDI) at week 2.
- Trial name
- NCT07732010
- Testing
- TRYPTYR (Acoltremon ophthalmic solution 0.003%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Dry Eye Disease (DED)
Dose-Finding Study of HUC1-394 in Participants With Dry Eye Disease
Clinical trial aims to determine the optimal dosing regimen by evaluating the efficacy and safety of HUC1-394 across different dosing frequencies in patients with moderate to severe dry eye disease.
- Trial name
- NCT07656688
- Testing
- HUC1-394
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Huons Co., Ltd.
Dry Eye Disease (DED)
Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease
A study to evaluate the effect of over- the- counter (OTC) lubricating eye drops on tolerability, symptoms and visual outcomes in patients with dry eye disease (DED)
- Trial name
- NCT07676084
- Testing
- Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andover Research Eye Institute
Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis
Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease
Sjögren's syndrome is a condition in which the immune system attacks the body's moisture-producing glands. This often causes severe dry eye, leading to discomfort, irritation, blurred vision, and damage to the eye surface.
- Conditions
- Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis, Dry Eye Disease (DED)
- Trial name
- INFLIXIDRY (NCT07671222)
- Testing
- Infliximab 0.1%, Loteprednol
- Where
- Mexico
- Volunteers
- 38 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Dry Eye Syndrome (DES), Dry Eye Disease (DED)
A Multicenter, Open-Label Study to Evaluate Perioperative Treatment of Dry Eye With Miebo® in Subjects Undergoing LASIK
Compare eye dryness following laser-assisted in situ keratomileusis (LASIK) surgery to eye dryness prior to receiving perioperative Miebo in patients with dry eye disease (DED)
- Trial name
- Sonoran (NCT07650708)
- Testing
- Miebo four times per day
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Vance Thompson Vision
Dry Eye Disease (DED), MGD-Meibomian Gland Dysfunction
The Effect of Eyelid Support Plate Assisted Eyelid Massage on Meibomian Gland Dysfunction: a Randomized Controlled Trial
This study aims to conduct a randomized controlled clinical trial to compare the efficacy of a new type of massage device - eyelid support plate and glass rod assisted eyelid massage in improving MGD related dry eye symptoms, and…
- Trial name
- NCT07633938
- Testing
- eyelid support plate assisted eyelid massage, glass rod assisted eyelid massage
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye Disease (DED)
Randomized Clinical Trial of Artificial Tears With and Without Preservatives in Patients With Dry Eye Disease
Dry Eye Disease (DED) is a common, chronic ocular surface disorder characterized by tear film instability, ocular discomfort, and visual disturbance.
- Trial name
- NCT07635849
- Testing
- Carboxy methyl cellulose, Preservative free Carboxy methyl cellulose
- Where
- Nepal
- Volunteers
- 80 people
- Sponsor
- Pokhara Academy of Health Sciences, Western Regional Hospital
Dry Eye Disease (DED)
Comparison of Conjunctival Goblet Cell Density in Dry Eye Patients Treated With Cyclosporine 0.1% Dissolved in Perfluorobutylpentane (Vevye®) or Generic 0.05% Cyclosporine Emulsion for 8 Weeks
This goal of this clinical trial is to compare the effects of two approved cyclosporine eye drops that have different concentrations and vehicles on the number of mucus producing conjunctival goblet cells in patients with dry eye…
- Trial name
- CSAGCD (NCT07368595)
- Testing
- Vevye®, Cyclosporine emulsion
- Volunteers
- 60 people
- Sponsor
- Baylor College of Medicine
Dry Eye Disease (DED), Diabete Mellitus
Impact of GLP-1 Receptor Agonists on Dry Eye Disease in Patients With Type 2 Diabetes Mellitus and Obesity
Diabetes mellitus (DM), prediabetes, and obesity are emerging as major global public health problems, with their epidemic spread continuously increasing over the past decades.
- Conditions
- Dry Eye Disease (DED), Diabete Mellitus, GLP-1, Ocular Surface
- Trial name
- GALENOS (NCT07605572)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital