Clinical trials: Dry Eye Symptoms
Dry Eye, Ocular Inflammation
Closed Eye Neutrophils in Dry Eye Disease
The purpose of this prospective study is to evaluate different inflammatory cells that accumulate on the ocular surface, during sleep, and how these cells may contribute to dry eye disease.
- Trial name
- NCT03332342
- Testing
- Eye wash
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Systemic Lupus Erythematosus, Sjogren's Syndrome
COVID-19 Vaccination in Rheumatic Disease Patients
The research is being done to study the immune responses to COVID-19 vaccination in patients with rheumatic diseases.
- Conditions
- Systemic Lupus Erythematosus, Sjogren's Syndrome, Inflammatory Myositis, Psoriatic Arthritis
- Trial name
- NCT04839315
- Testing
- mRNA COVD19 vaccine
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Mayo Clinic
Sjogren's Syndrome
Aerobic Exercise in Primary Sjögren's Syndrome
The purpose of this sudy is to investigate the effects of a regular aerobic exercise on aerobic capacity, fatigue, depression, quality of life, perception of symptoms and disease activity in women with pSS.
- Trial name
- AEPSS (NCT02370225)
- Testing
- aerobic exercise
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Samira Tatiyama Miyamoto, PhD
Dry Eyes, Allergic Conjunctivitis
Evaluating Patients With Eye Allergies and Determining if There Are Also Dry Eyes
Evaluating the percentage of patients that suffer from eye allergies and determining whether they also have dry eyes.
- Trial name
- NCT01679015
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Schwartz Laser Eye Center
Dry Eye Disease, Kerato Conjunctivitis Sicca
Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease
This is a Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel Group Phase 2 Trial Evaluating the Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Signs and Symptoms of Dry Eye…
- Trial name
- NCT05119920
- Testing
- Pilocarpine Ophthalmic Topical Cream, Dose 1, Pilocarpine Ophthalmic Topical Cream, Dose 2, Pilocarpine Ophthalmic Topical Cream, Dose 3
- Where
- 19 sites in United States
- Volunteers
- 226 people
- Sponsor
- Glaukos Corporation
Dry Eye Disease
Evaluation of the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (the RAINIER Study)
The objective of this study is to evaluate the safety and effectiveness of OC-02 nasal spray compared to placebo on signs and symptoms of dry eye disease (DED).
- Trial name
- NCT03633461
- Testing
- OC-02 (simpinicline) nasal spray
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Oyster Point Pharma, Inc.
Dry Eye
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Collecting data using Kera Sol tear usage during the initial two-week post-operative period after Laser-Assisted In Situ Keratomileusis (LASIK) has on the signs and symptoms of surgical temporary ocular discomfort syndrome (STODS)
- Trial name
- NCT07155070
- Testing
- Kera Sol Eye Drops
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Rheumatoid Arthritis, Spondyloarthritis
Pregnancy and Medically Assisted Conception in Rare Diseases
Rare diseases frequently affect women of childbearing age. Pregnancy in these women has become less rare, but remains associated with high levels of complications.
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- EGR2 (NCT02450396)
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Eye
Survey: Evaluation of Ocular Surface Disease Symptoms and Patient Satisfaction With Thealoz® Duo After 84 Days of Daily Treatment
Multi-centre, international, non-interventional, prospective survey
- Trial name
- NCT04803240
- Testing
- Thealoz Duo
- Where
- United Kingdom
- Volunteers
- 310 people
- Sponsor
- Laboratoires Thea
Computer Vision Syndrome, Asthenopia
Yogic Eye Exercises for Computer Vision Syndrome in Female Design Students
Computer vision syndrome (CVS) is a cluster of eye and musculoskeletal complaints - dryness, redness, blurred vision, foreign body sensation, excessive tearing, and neck, shoulder or back pain - that arises from prolonged work at…
- Conditions
- Computer Vision Syndrome, Asthenopia, Eye Strain, Dry Eye
- Trial name
- NCT07816419
- Testing
- Yogic eye exercise programme
- Where
- Saudi Arabia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Saud University
Dry Eye Syndromes
Management of Signs and Symptoms Associated With Dry Eye Disease
A prospective randomized, and controlled study to compare the effectiveness of PROKERA® SLIM plus standard of care (SOC) in the PROKERA® SLIM Arm to SOC alone in the Control Arm.
- Trial name
- NCT04015219
- Testing
- Self retained cryopreserved amniotic membrane, lifitegrast ophthalmic solution
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- BioTissue Holdings, Inc
Eye Fatigue
Eye Care Benefits of Anti-Aging Compound Capsules in Healthy Adults
This study aims to evaluate the eye care benefits of anti-aging compound capsules in healthy adults. Participants will consume anti-aging compound capsules containing botanical extracts, omega-3 fatty acids, vitamins, minerals…
- Trial name
- Eye Care (NCT07657936)
- Testing
- Anti-Aging Compound Capsules
- Where
- Taiwan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Dry Eye, Cataract Surgery
Use of Prophylactic Lubricating Drops After Cataract Surgery
This is a randomised controlled trial to assess the use of prophylactic lubricant eye-drops for 6 weeks following uncomplicated, routine cataract surgery to improve patient satisfaction and symptoms of dry eye, compared to…
- Conditions
- Dry Eye, Cataract Surgery, Patient Related Outcome Measures, Patient Satisfaction
- Trial name
- NCT04131335
- Testing
- AEONTM Repair, Routine post-operative eye drops used.
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Dry Eye Syndromes
The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients
BAK is one of the most frequent preservatives in eye drops. BAK is a quaternary ammonium salt with surfactant qualities. It can be bacteriostatic or bactericidal depending on the concentrations used.
- Trial name
- NCT01280110
- Testing
- Hydroxypropylmethylcellulose, Carboxymethylcellulose
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dry Eye Disease
A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment
This study aims to evaluate the performance of biomarkers and their responsiveness to standard-of-care treatments (Vevye® or Xiidra®), in participants with dry eye disease (DED) compared to healthy volunteers (control…
- Trial name
- NCT07025811
- Testing
- Vevye®, Xiidra®
- Where
- 8 sites in United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Systemic Lupus Erythematosus, Inflammatory Myopathy
BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases
The objective of this study is to evaluate the efficacy and safety of BCMA/CD19 chimeric antigen receptor (CAR)-modified T cells in the treatment of autoimmune diseases.
- Conditions
- Systemic Lupus Erythematosus, Inflammatory Myopathy, Systemic Sclerosis (SSc), ANCA-associated Vasculitis
- Trial name
- NCT06794008
- Testing
- BCMA-CD19 CAR-T therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University People's Hospital
Dry Eye Syndromes
Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome
Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the elderly population. Topically administered lubricants are the basis for treatment of this disease.
- Trial name
- NCT02986750
- Testing
- Thealoz Duo Eye Drops, Optive Eye Drops, Systane Ultra Eye Drops
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Evaporative Dry Eye
Safety and Effectiveness of EyePeace on Signs and Symptoms of Dry Eye Disease
In this study, the EyePeace an eye massager will be compared with a standard-of-care warm compress treatment with evaporative dry eye disease.
- Trial name
- NCT06158997
- Testing
- EyePeace, Heated Eye Mask
- Where
- China
- Volunteers
- 60 people
- Sponsor
- He Eye Hospital
Neovascular Age-related Macular Degeneration
Efficacy and Safety of Ranibizumab 0.5 mg Administered as Two Alternative Dosing Regimens in Chinese Patients With nAMD (Age Related Macular Degeneration)
The study evaluated the efficacy and safety of two different dosing regimens of ranibizumab (either monthly injections or injections as-needed based on the stability of a patient's vision) in Chinese patients with wet age-related…
- Trial name
- DRAGON (NCT01775124)
- Testing
- Ranibizumab
- Where
- 23 sites in China
- Volunteers
- 332 people
- Sponsor
- Novartis Pharmaceuticals