Clinical trials: Dry Eye Symptoms
Dry Eye Syndrome (DES), Laser Acupuncture
Laser Acupuncture on Dry Eye and Sjögren's Syndrome-related Dry Eye Symptoms (LADESJS)
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate the efficacy of adding laser acupuncture at Fengchi (GB20), Zanzhu (BL2), Hegu (LI4), and Quchi (LI11) acupoints to standard care for the treatment…
- Conditions
- Dry Eye Syndrome (DES), Laser Acupuncture, Sjögren's Syndrome (SS)
- Trial name
- LADESJS (NCT06780293)
- Testing
- Laser acupuncture (LA), Numerical Rating Scale (NRS), Schirmer's test
- Where
- Taiwan
- Volunteers
- 140 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dry Eye Syndromes
Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD
The purpose of this study is to evaluate if, in patients with meibomian gland dysfunction (MGD), treatment with the Lumenis M22 Intense Pulsed Light (IPL) system causes a reduction in dry eye symptoms post-treatment, compared to…
- Trial name
- NCT02621593
- Testing
- M22-IPL
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Lumenis Be Ltd.
Ocular Pain, Dry Eye
Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain
This study is designed to provide clinical data on how acoltremon ophthalmic solution 0.003% affects tear production and ocular symptoms in participants with tear deficiency and concurrent neuropathic corneal pain.
- Trial name
- AURORA (NCT07849803)
- Testing
- acoltremon ophthalmic solution 0.003%
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of South Florida
Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema
Cool vs Room-temperature Artificial Tears
Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort.
- Conditions
- Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye, Cystoid Macular Edema
- Trial name
- NCT05832996
- Testing
- Refresh Plus Preservative-free Lubricant Eye Drops
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Rheumatic Diseases, Adult Onset Still Disease
Rheumatology Patient Registry and Biorepository
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
- Conditions
- Rheumatic Diseases, Adult Onset Still Disease, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT04402086
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yale University
Age Related Macular Degeneration
Survival of Monocytes Collected From Patients With Atrophic AMD in Retinal Pigmented Epithelium Explants
Age-related macular degeneration (AMD) affects 2 million people in France and is the main cause of irreversible blindness in France. All patients initially have an early form of the disease.
- Trial name
- SURViVOR (NCT04697095)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Dry Eye Syndromes
Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation
This study evaluates the safety and effectiveness of the Intranasal Tear Neurostimulator applied intranasally (active) compared with the same device applied extranasally (control) relating to symptoms of dry eye exacerbated by…
- Trial name
- NCT02910713
- Testing
- Intranasal Tear Neurostimulator
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- Allergan
Dry Eye Syndrome, Sjogren's Syndrome
Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome
This study combines data from two trials testing acupuncture (ACUDES) and a Chinese herbal tea bag TBDESJS for Dry Eye Syndrome and Sjögren's syndrome. Both treatments improved tear production.
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06475027
- Testing
- TBDESJS, Acupuncture
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Ocular Inflammation, Keratoconjunctivitis
Tolerability Comparison of Flarex to Lotemax SM
This study compared the ocular tolerability of fluorometholone acetate ophthalmic suspension 0.1% (FLAREX) to loteprednol etabonate ophthalmic gel 0.38% (Lotemax SM) in adult subjects.
- Conditions
- Ocular Inflammation, Keratoconjunctivitis, Dry Eye Disease (DED), Post-operative Complications
- Trial name
- NCT07588074
- Testing
- Fluorometholone Acetate Ophthalmic Suspension 0.1%, Loteprednol Etabonate Ophthalmic Gel 0.38%
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Harrow Inc
Eye Diseases, Ocular Surface Disease
Effect on Ocular Surface Symptoms of Online Education
retrospective, observational study.
- Conditions
- Eye Diseases, Ocular Surface Disease, Dry Eye
- Trial name
- NCT04960696
- Testing
- OSDI, tear break up time, schirmer
- Where
- Turkey (Türkiye)
- Volunteers
- 315 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Dry Eye Syndromes
Xiidra vs. Xiidra + Dextenza Treatment for Dry Eye Disease
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in patients with dry eye who are beginning treatment with Xiidra (lifitegrast ophthalmic solution) to reduce the signs and…
- Trial name
- NCT04413253
- Testing
- Lifitegrast 5% Ophthalmic Solution, Dexamethasone Intracanalicular Insert, 0.4mg with Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Eye Surgeons of Indiana
Dry Eye Disease
Evaluation of the Safety, Tolerability and Efficacy of iNexin™ for the Treatment of the Signs and Symptoms Associated With Dry Eye Disease
The primary objective of this study is to evaluate the safety and tolerability of iNexin™ The secondary objective is to compare the efficacy of iNexin™ to Vehicle for the treatment of the signs and symptoms associated with dry…
- Trial name
- NCT05031806
- Testing
- iNexin™ (0.08% aCT1), iNexin™ (0.4% aCT1), iNexin™ (2.0% aCT1)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Xequel Bio, Inc.
Dry Eye
Study on Curative Effect and Mechanism of Acupuncture on Neuropathic Pain in Dry Eye Disease
This project is designed as a prospective, randomized, open, controlled clinical trial. For the first time, acupuncture was applied to the treatment of dry ocular neuropathic pain.
- Trial name
- NCT04668131
- Testing
- Sodium hyaluronate eye drops, acupuncture
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Dry Eye Disease
Concentration of Ofloxacin Into the Aqueous Humour of Patients With Dry Eye Disease
After topical installation of one drop of 0.3% commercially available ofloxacin (Oxatrex®) four times at intervals of 15min in catarract patients with Dry Eye Disease, aqueous humour samples will be collected intraoperatively…
- Trial name
- NCT05213156
- Testing
- Oxatrex
- Where
- Greece
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University Hospital of Patras
Cataract, Lens Subluxation
Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery
To study the efficacy of an ocular bandage contact lens for the treatment of dry eye after complicated and combined cataract surgery
- Conditions
- Cataract, Lens Subluxation, Hypermature Cataract, Corneal Opacity
- Trial name
- NCT04120389
- Testing
- bandage contact lenses(PureVision; Bausch & Lomb Inc., Rochester, NY), phacoemulsification
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rheumatoid Arthritis, Lupus Erythematosus, Systemic
Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases
Fatigue is common and disabling for most patients with inflammatory rheumatic disease. Therapies designed to improve physical activity and 'talking' treatments, which positively help patients change the way they think and behave…
- Conditions
- Rheumatoid Arthritis, Lupus Erythematosus, Systemic, Axial Spondyloarthritis, Psoriatic Arthritis
- Trial name
- LIFT (NCT03248518)
- Testing
- Usual Care, Cognitive behavioural approach, Personalised Exercise Programme
- Where
- 6 sites in United Kingdom
- Volunteers
- 368 people
- Sponsor
- University of Aberdeen
Sjogren's Syndrome, Cough
Pulmozyme for Sjogren's Associated Cough
Patients with Sjogren's disease have destruction of the mucus secreting cells in the airway. This manifestation of the disease leads to the common complaint of persistent dry cough that is seen in many of these patients.
- Trial name
- NCT01357447
- Testing
- Dornase alfa, Saline
- Where
- United States
- Sponsor
- UConn Health
Dry Eye Disease
A Phase 3 Study to Evaluate AZR-MD-001 in Patients with Abnormal Meibomian Gland Function and Dry Eye Disease (DED)
This study is a multicenter, double-masked, vehicle-controlled, randomized, parallel group study designed to evaluate the treatment of abnormal meibomian gland function and associated symptoms of DED using either AZR-MD-001 0.5%…
- Trial name
- NCT06329791
- Testing
- AZR-MD-001, Vehicle
- Where
- 16 sites in United States
- Volunteers
- 500 people
- Sponsor
- Azura Ophthalmics
Dry Eye Syndrome (DES)
Potential Role of Ocular Surface Microbiome in Dry Eye: Microbial Interactions and Symptom Alleviation
Study design and sample collection This study is randomized, double-blind, and prospective trial. The inclusion criteria were as follows: patients aged 19 years or older with symptoms of dry eye syndrome.
- Trial name
- NCT06936462
- Testing
- topical cyclosporine eyedrops and hyaluronic eyedrops
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Opthalomology/Dry Eye
An Interventional, Confirmative, Post Marketing Clinical Followup (PMCF) Study to Evaluate Performance and Safety of Ophthalmic Solutions Used to Relieve Dry Eyes Like Symptoms in Glaucoma Patients.
Study Rationale: The glaucomas are a group of optic neuropathies characterized by progressive degeneration of retinal ganglion cells.
- Trial name
- M-GLAU-01-2020 (NCT05773976)
- Testing
- Afomill Refreshing Soothing, Afomill Anti-redness Eye Drops, Iridil
- Where
- 2 sites in Italy
- Volunteers
- 59 people
- Sponsor
- Montefarmaco OTC SpA