Clinical trials: Dry Eye Symptoms
Dry Eye
Microvascular and Inflammatory Responses of 0.05 Cyclosporine Eye Drop (II) in Treatment of Dry Eye
To explore the law of changes in ocular surface inflammation when 0.05% cyclosporine eye drops (II) is used to treat dry eye, 50 cases of mild to moderate dry eyes were included.
- Trial name
- NCT05131152
- Testing
- Cyclosporine, oculus keratograph, in vivo laser confocal microscopy, Functional slit lamp biomicroscopy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye, Meibomian Gland Dysfunction
TearCare System to Treat Dry Eye Disease
In this study, the TearCare System will be compared with the LipiFlow Thermal Pulsation System in patients with dry eye disease.
- Trial name
- OLYMPIA (NCT03857919)
- Testing
- TearCare, LipiFlow
- Where
- 10 sites in United States
- Volunteers
- 235 people
- Sponsor
- Sight Sciences, Inc.
Depression, Quality of Life
Impact of Breathing Exercises and Meditation on Quality of Life in Dry Eye Disease Patients: A Pilot Study
People staring at computer screens for long hours, blinking less frequently, or having long-term contact lens wear are prone to dry eye disease (DED).
- Conditions
- Depression, Quality of Life, Dry Eye, Anxiety
- Trial name
- NCT03345381
- Testing
- SKY + ASTM + usual care, Usual care
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Eye Drops Self-instillation, Glaucoma
Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS
Glaucoma is a large group of intraocular pressure-sensitive conditions that can cause progressive retinal ganglion cell (RGC) damage/loss and ultimately results in visual field loss that can produce irreversible blindness.
- Conditions
- Eye Drops Self-instillation, Glaucoma, Dry Eye
- Trial name
- Zolymbus (NCT07845357)
- Testing
- preservative free ZOLYMBUS™ 0.01%.
- Volunteers
- 40 people
- Sponsor
- Southern College of Optometry
Dry Eye
Efficacy and Safety of a New Multi-dose Lubricant Eye Drop Concomitant With Restasis® (Cyclosporine A) for the Treatment of Dry Eye Symptoms
To evaluate the efficacy, safety and tolerability of a combination of Optive® Artificial Tears with Restasis®.The primary hypothesis is that the Ocular Surface Disease Index (OSDI) score and symptoms will be the same or lower…
- Trial name
- NCT00405457
- Testing
- Restasis, Optive Tears
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Innovative Medical
Sjögren Syndrome, Sicca Syndrome
N-acetylcysteine for Primary Sjögren's Syndrome
N-acetylcysteine (NAC) allows the elimination of reactive oxygen species (ROSs) and it has an anti-inflammatory effect. For this reason, NAC has been used and researched for treatment of several diseases, such as autoimmune…
- Trial name
- NACSS (NCT04793646)
- Testing
- N-acetylcysteine syrup
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Dry Eye, Contact Lens Acute Red Eye
Performance and Tolerability of the Medical Device LACRIACT
The goal of this study is testing LACRIACT® eye drops, a medical device, to see how well it works and if people can use it safely.
- Conditions
- Dry Eye, Contact Lens Acute Red Eye, Photophobia, Discomfort
- Trial name
- NCT06159569
- Testing
- LACRIACT
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Laboratórios Baldacci S.A
Dry Eye Disease (DED)
The Effectiveness of Systane PRO Preservative Free Verses Blink Triple Care Preservative Free
The goal of this investigational study is to determine if Systane PRO Preservative Free is non-inferior to BLINK TRIPLE CARE in the clinically significant improvement of signs and symptoms of dry eye in patients over 4 weeks.
- Trial name
- SYSTANEvBLINK (NCT07745062)
- Testing
- Systane PRO, Blink tears
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Gordon Schanzlin New Vision
Probiotic, Ocular Surface Disease
Efficacy and Safety of Oral Probiotics on Ocular Symptoms and Gut Microbiome of Children with Vernal Keratoconjunctivitis
The primary goal of this study is to determine the effects of oral probiotics on the severity of ocular symptoms and the alterations of the gut microbiome of children (4-18 years old) with vernal keratoconjunctivitis.
- Conditions
- Probiotic, Ocular Surface Disease, Ocular Diseases, Ocular Dryness
- Trial name
- NCT06793514
- Testing
- Probiotic
- Volunteers
- 32 people
- Sponsor
- Mohsen Pourazizi
Dry Eye Disease
Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Laser-assisted in Situ Keratomileusis (LASIK)
Evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray for amelioration of signs and symptoms of dry eye disease in subjects following laser-assisted in situ keratomileusis (LASIK).
- Trial name
- NCT05082974
- Testing
- OC-01 (varenicline 0.6mg/ml) nasal spray
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision ND
Dry Eye Disease (DED)
Perfluorohexylcotane (NOV03) for the Treatment of Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Gobi Study)
This trial will evaluate the efficacy, safety, and tolerability of NOV03 ophthalmic solution in comparison to a saline control for the treatment of the signs and symptoms of Dry Eye Disease (DED) associated with Meibomian Gland…
- Trial name
- NCT04139798
- Testing
- NOV03
- Where
- 29 sites in United States
- Volunteers
- 599 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye, Eye Fatigue
A Randomized Controlled Trial to Evaluate the Safety and Efficacy of an Oral Supplement in Supporting Vision and Eye Health
This is a 4-week virtual randomized, triple-blinded, placebo-controlled clinical trial evaluating the safety and efficacy of Eye Empower, an oral supplement, in adults aged 45 or older experiencing dry eyes, irritation, and…
- Trial name
- NCT07123584
- Testing
- Eye Empower
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bio Nature Health
Diabetic Eye Problems
Diquafosol Ophthalmic Solution for Dry Eye Symptoms
Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells.
- Trial name
- NCT04980144
- Testing
- 3% Diquafosol tetrasodium, 0.1% hyaluronate
- Where
- China
- Volunteers
- 101 people
- Sponsor
- He Eye Hospital
Dry Eye Symptoms
Comparison of Ocular Lubricants in People With Symptoms of Dry Eye
Ocular dryness and discomfort are symptoms commonly associated with dry eye. Lubricating eye drops, also called artificial tears, are often used to moisten the eye and provide relief from these symptoms.
- Trial name
- SPHINX (NCT07451184)
- Testing
- Propylene glycol 0.6%, 3% trehalose and 0.15% sodium hyaluronate
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Waterloo
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Meibomian Gland Dysfunction, Dry Eye
Evaluating Impact of Systane iLux on Dryness Symptoms and Wearing Time in Contact Lens Users
To evaluate dry eye symptoms and contact lens wearing times after a single iLux treatment by evaluating change from baseline in OSDI scores, subjective CLDEQ8 and CL wearing time questionnaires, and meibomian gland secretion…
- Trial name
- NCT05306561
- Testing
- Systane iLux thermal pulsation treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Periman Eye Institute
Dry Eye
Efficacy Study of Ketorolac and HPMC to Treat Dry Eye
The purpose of this study is to determine whether ketorolac and Hydroxypropyl Methylcellulose are effective in the treatment of Dry Eye.
- Trial name
- NCT03693183
- Testing
- Ketorolac/HPMC, HPMC, Vehicle
- Where
- United States
- Sponsor
- ORA, Inc.
Dry Eye
Performance and Safety Assessment of T2769 in Contact Lens Wearers With Dry Eye Symptoms.
This is a confirmatory clinical investigation. The objective is to collect new additional clinical data demonstrating the safety and performance of the device in the contact-lens wearing population with dry eyes.
- Trial name
- NCT05931861
- Testing
- T2769
- Where
- 6 sites in Bulgaria
- Volunteers
- 34 people
- Sponsor
- Laboratoires Thea
Dry Eye
Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)
The purpose of the study is to analyze the sensation to eye drops containing menthol in people with healthy eyes and in people with dry eyes. This study also examines the temperature of your eye using an Infrared Camera.
- Trial name
- NCT02985827
- Testing
- Rohto (r) Hydra, Systane (r) Ultra
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.