Clinical trials: Dry Eye Symptoms
Dry Eye
A Clinical Evaluation Pilot Study of the Efficacy of Blink® Tears Lubricant Eye Drops for the Relief of Dry Eye Symptoms Following Implantation of Tecnis® Multifocal Introcular Lens
To evaluate the safety and efficacy of BLINK™ tears compared with NO topical artificial tear use in improving subject's visual performance and reduce ocular symptoms of discomfort in subjects who have undergone cataract surgery…
- Trial name
- NCT01061268
- Testing
- No topical artificial tear, Blink® Tears Lubricant Eye Drops
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Innovative Medical
Moderate to Severe Dry Eye Disease
Senofilcon A Lenses in Moderate to Severe Dry Eye Disease
A clinical trial using Senofilcon A daily lenses in the treatment of moderate to severe dry eye. This a comparison between signs and symptoms prior to and during treatment.
- Trial name
- NCT04096898
- Testing
- Senofilcon A contact lens
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Illinois Chicago
Dry Eye
Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses
This research study is to see if using Lacrifill is safe, easy to use, and helpful for people who wear contact lenses but can't wear them comfortably for long.
- Trial name
- NCT07510620
- Testing
- Lacrifill
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists
Dry Eye, Keratoconjunctivitis Sicca
A Randomized Study of Smile Exercise for Dry Eye
The objective of the study is to evaluate the effectiveness of laughter therapy in relieving the symptoms of dry eye disease.
- Conditions
- Dry Eye, Keratoconjunctivitis Sicca, Eye Diseases, Corneal Diseases
- Trial name
- NCT04421300
- Testing
- smile exercise, 0.1% sodium hyaluronate eye drop
- Where
- China
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Age Related Macular Degeneration
Study of Photobiomodulation to Treat Dry Age-Related Macular Degeneration
The purpose of this research study is to determine if photobiomodulation is an effective treatment of Dry Age-Related Macular Degeneration (AMD) and vision loss associated with the disease.
- Trial name
- LIGHTSITE1 (NCT02725762)
- Testing
- LT-300 Active (PBM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- LumiThera, Inc.
Sjogren's Syndrome
Olfactory and Taste Disturbances in Sjogren's Syndrome
Sjögren syndrome is an autoimmune disease, responsible for xerostomia and xerophthalmia. Other organs and tissues can be affected: the skin, vaginal and nasal mucous membranes.
- Trial name
- TOG_SJOGREN (NCT04909112)
- Testing
- Evaluation of olfactory function, Evaluation of taste function, Evaluation of (intra-nasal and oral) trigeminal functions
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Dry Eye, Dry Eye Syndromes
The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers
This study assesses the impact of two differing ocular hygiene regimens prior to cataract surgery. The first regimen includes an omega-3 supplement and the second without, and both include an at-home lid wipe and cleansing eye…
- Conditions
- Dry Eye, Dry Eye Syndromes, Cataract
- Trial name
- NCT05990712
- Testing
- Omega-3, Trehalose, Zocular Eyelid System Treatment
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Uptown Eye Specialists
Dry Eye Disease (DED)
Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease
A study to evaluate the effect of over- the- counter (OTC) lubricating eye drops on tolerability, symptoms and visual outcomes in patients with dry eye disease (DED)
- Trial name
- NCT07676084
- Testing
- Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andover Research Eye Institute
Dry Eye Syndromes, Dry Eye
The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease
The central hypothesis is that inflammation contributes to dry eye and that rinsing the palpebral conjunctiva, bulbar conjunctiva, and fornices will reduce the inflammatory burden on the ocular surface.
- Conditions
- Dry Eye Syndromes, Dry Eye, Ocular Surface Disease
- Trial name
- RINSE-A (NCT07618364)
- Testing
- Rinsada
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Rinsada
Sjogren's Disease, Fatigue
Explanatory Factors and Predictors of Fatigue in Patients With Sjögren's Disease: A 3-month Longitudinal Study
This prospective longitudinal study will be conducted in patients diagnosed with Sjögren's disease who are followed at the rheumatology outpatient clinic of Kahramanmaras Sutcu Imam University Medical Faculty Hospital.
- Trial name
- NCT07544394
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Sjogren's Syndrome
Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease
Background: Sjogren disease is an autoimmune disease - that is, a disease that causes the body's immune system to attack its own organs and tissues. Sjogren disease can affect the kidneys, lungs, or other organs.
- Trial name
- NCT07281456
- Testing
- Tofacitinib
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- Kauai (NCT02188160)
- Testing
- KPI-121
- Where
- 11 sites in United States
- Volunteers
- 150 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Dry Eye
An Observational Study to Assess Optive MEGA-3 (OM3) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED)
Dry Eye Disease (DED) is a condition where the tear film of the eye becomes unstable and along with ocular surface inflammation and damage leads to inadequate tear production and eye lubrication.
- Trial name
- NCT06439394
- Testing
- Optive MEGA-3 (OM3)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- AbbVie
Dry Eye Symptoms, Allergic Conjunctivitis of Both Eyes
Kelulut Honey for Allergic Conjunctivitis and Dry Eye Symptoms
The goal of this clinical trial is to learn if oral Kelulut honey works to improve eye symptoms in adults with allergic conjunctivitis. It will also look at how safe Kelulut honey is when taken as a daily supplement.
- Trial name
- NCT07273747
- Testing
- Kelulut Honey 60 g Oral Supplement, Kelulut Honey 120 g Oral Supplement
- Where
- Malaysia
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
Lupus Erythematosus, Systemic, Sjogren's Syndrome
Dehydroepiandrosterone Administration in Women With Systemic Lupus Erythematosus or Primary Sjögren's Syndrome
The purpose of the study is to examine whether dehydroepiandrosterone (DHEA) administration improves fatigue and general well-being in patients with systemic lupus erythematosus or primary Sjögren's syndrome
- Trial name
- NCT00391924
- Testing
- Dehydroepiandrosterone
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Dry Eye Syndromes
A Study to Determine the Relief of Dry Eye Symptoms With the Use of TheraTears® Products (DUNLIN)
Dry eye is a very common condition that most often affects women and the elderly, and can be caused when the eyes do not produce enough tears, or when the tears evaporate too quickly.
- Trial name
- DUNLIN (NCT02014922)
- Testing
- TheraTears® Lubricant Eye Drop, TheraTears® preservative-free single-use containers, TheraTears® Nutrition
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Turner Syndrome, Ovarian Failure, Premature
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure
Premature ovarian failure (POF) is known to be associated with an increased risk of ocular surface disease (dry eye), likely due to the reduction of both estrogens and androgens seen in this condition.
- Conditions
- Turner Syndrome, Ovarian Failure, Premature, Sex Chromosome Aberrations, Menopause
- Trial name
- NCT00471731
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Epiretinal Membrane, Dry Age Related Macular Degeneration
(CIRRUS-2023-1) CLINICAL CLIN Assessment of PathFinder 1.0 on the CIRRUS 6000 and the CIRRUS 5000
This study will measure how well PathFinder 1.0 detects retinal abnormalities on macular cube OCT B-scans by assessing its sensitivity and specificity.
- Conditions
- Epiretinal Membrane, Dry Age Related Macular Degeneration, Macular Abnormalities, Retina Disease
- Trial name
- NCT07680244
- Testing
- PathFinder 1.0 on CIRRUS HD-OCT
- Where
- 6 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec-Dublin CoCe
Age-related Macular Degeneration
Study to Assess the Efficacy and Safety of Brolucizumab 6mg Compared to Aflibercept 2 mg in a Treat-to-control Regimen (TALON)
This was a 64-week randomized, double-masked, multi-center, active-controlled, two-arm study in patients with neovascular age related macular degeneration (nAMD) who have not previously received anti- vascular endothelial growth…
- Trial name
- TALON (NCT04005352)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 118 sites in United States, Argentina and 18 more
- Volunteers
- 734 people
- Sponsor
- Novartis Pharmaceuticals
Age-related Macular Degeneration
Tools to Optimize Patient Presentation After Onset of Exudative Age-Related Macular Degeneration (AMD)
Exudative age-related macular degeneration ("wet" AMD) continues to be a leading cause of central vision loss in the US for those over fifty years of age, despite the availability of several effective interventions to contain…
- Trial name
- NCT01337414
- Testing
- VMS diary booklet, Standard of Care
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Johns Hopkins University