Clinical trials: Dry Eye Symptoms
Advanced Dry Macular Degeneration
Alpha MSH in Ocular Disease
The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease.
- Trial name
- NCT03451578
- Testing
- Alpha MSH assay
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Sjogren's Syndrome, Xerostomia
Diagnostic Interest of the Buccal Schirmer Test in Xerostomia During Sjögren's Syndrome: XERODIAG
Xerostomia is a common and very bothersome manifestation that impairs the quality of life in Sjogren's syndrome. Its diagnosis mainly relies on the measurement of salivary flow (SF).
- Conditions
- Sjogren's Syndrome, Xerostomia, Diagnosis
- Trial name
- XERODIAG (NCT06530940)
- Testing
- Buccal Schirmer Test
- Volunteers
- 180 people
- Sponsor
- University Tunis El Manar
Neovascular Age-related Macular Degeneration
An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study
The purpose of this extension study was to evaluate the efficacy and safety of brolucizumab used in a Treat-to-Control-regimen for treatment of patients with neovascular age-related macular degeneration who have completed the…
- Trial name
- TALON Ext (NCT04597632)
- Testing
- brolucizumab
- Where
- 60 sites in United States, Australia and 14 more
- Volunteers
- 248 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes, Dry Eye
Prospective Study To Assess The Safety And Effectiveness Of Tixel Treatment On Dry Eye Symptoms In Asian Patients
Pilot study where effect of standard Tixel treatment as used for periorbital wrinkles would be assessed on Dry Eye Disease symptoms and signs in Asian Patients.
- Trial name
- DED (NCT04260893)
- Testing
- Tixel
- Where
- Cambodia
- Volunteers
- 44 people
- Sponsor
- Novoxel Ltd.
Neovascular Age-related Macular Degeneration (nAMD)
Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD)
The purpose of this study was to generate additional safety and effectiveness data in Indian neovascular age-related macular degeneration (nAMD) patients that more closely resemble the real-world population intended to be treated…
- Trial name
- NCT05269966
- Testing
- Injection Brolucizumab
- Where
- 10 sites in India
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye, Dry Eye Syndromes
Intra-Nasal Mechanical Stimulation (INMEST) As a Treatment Method for the Relief of Symptoms of Dry Eye
The purpose of the study is to investigate the degree of symptom relief in people with signs or symptoms of dry eyes after self-treatment at home with the Walther System delivering INMEST (intranasal mechanical stimulation).
- Trial name
- NCT05887336
- Testing
- Walther System, Non preserved ocular lubricants, Eye lid procedure
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 106 people
- Sponsor
- Abilion Medical Systems AB
Dry Eye Disease (DED), Dry Eye
Role of Corneal Nerves in Dry Eye Disease
This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss.
- Conditions
- Dry Eye Disease (DED), Dry Eye, Dry Eye Sensation, Corneal Nerve
- Trial name
- NCT06841471
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Daniela Nosch
Dry Eye, Dry Eye Disease
PMCF Study to Evaluate Performance and Safety of "Distilled Waters-based Eyedrops" Used to Relieve Dry Eye Symptoms
Dry eye disease (DED), also called keratoconjunctivitis sicca, is a common ocular condition characterized by a loss of homeostasis of the tear film and inflammation of the ocular surface.
- Conditions
- Dry Eye, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Trial name
- NCT05825586
- Testing
- Distilled waters based eye drops
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- C.O.C. Farmaceutici S.r.l.
Dry Eye Disease
Effect of NOV03 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Mojave Study)
The objectives of this trial are to assess the efficacy, safety, and tolerability of NOV03 ophthalmic solution in comparison to a saline control for the treatment of the signs and symptoms of Dry Eye Disease (DED) associated with…
- Trial name
- NCT04567329
- Testing
- NOV03, Saline Solution
- Where
- 35 sites in United States
- Volunteers
- 620 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Syndromes
Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye
The purpose of this study was to evaluate the safety and effectiveness of the Intranasal Tear Neurostimulator applied intranasally compared with the same device applied extranasally (control) in treating the symptoms of dry eye…
- Trial name
- NCT02313454
- Testing
- Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Allergan
Dry Eye, Dry Eye Disease
PMCF Study to Evaluate Performance and Safety of "HPMC-based Eyedrops" Used to Relieve Dry Eye Symptoms
Dry eye disease (DED), also called keratoconjunctivitis sicca, is a common ocular condition characterized by a loss of homeostasis of the tear film and inflammation of the ocular surface.
- Conditions
- Dry Eye, Dry Eye Disease, Kerato Conjunctivitis Sicca
- Trial name
- NCT05825599
- Testing
- Hydroxypropyl methylcellulose eye drops
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- C.O.C. Farmaceutici S.r.l.
Dry Eye Syndrome, Dry Eye
Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye
Thymosin Beta 4 (Tβ4) is a synthetic copy of the naturally-occurring 43-amino acid peptide that is found in a variety of tissues. Tβ4 promotes/accelerates wound repair in dermal, ocular, and cardiac animal models.
- Trial name
- NCT01387347
- Testing
- Thymosin beta 4
- Volunteers
- 72 people
- Sponsor
- ReGenTree, LLC
Xerostomia, Hyposalivation
A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study
The purpose of this study is to evaluate the clinical efficacy, safety and acceptability of our new oral salivary equivalent in the relief of signs and symptoms related to mouth dryness as compared to two distinct moisturizing…
- Conditions
- Xerostomia, Hyposalivation, Head and Neck Cancer, Sjögren Syndrome
- Trial name
- NIAGARA (NCT02049112)
- Testing
- Salivary equivalent, Aequasyal, Biotene
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Unither Pharmaceuticals, France
Dry Eye
The Effects of Dietary Supplementation With Omega-3 Fatty Acids on Symptoms of Dry Eye
The aim of this study is to compare ocular symptoms and signs when the test nutraceutical formulation (combination of flaxseed oil, borage oil and fish oil omega-3 fatty acids) is consumed daily over a 3 month period, with a…
- Trial name
- NCT03141931
- Testing
- Supplement
- Where
- Australia
- Volunteers
- 119 people
- Sponsor
- The University of New South Wales
Dry Eye Syndromes, Neuralgia
Patients With Ocular Neuropathic Pain: Description of Pain and Impact on Their Quality of Life
Some patients with dry eye may have severe disabling neuropathic pain. They describe spontaneous pain, dysesthesia, hyperalgesia or even allodynia.
- Conditions
- Dry Eye Syndromes, Neuralgia, Pain, Quality of Life
- Trial name
- QUALVIDON (NCT03296111)
- Testing
- Questionnaires on pain and quality of life
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dry Eye Disease (DED)
Clinical Study Aimed At Evaluating the Safety and Efficacy of Tear Substitute Formulations in the Treatment of Dry Eye Disease.
This clinical study is aimed at evaluating the safety and effectiveness of 2 test formulations (Rain and Mist), against an approved over-the-counter formulation (Systane Ultra) and a placebo (saline), in the treatment of moderate…
- Trial name
- NCT06633471
- Where
- Barbados
- Volunteers
- 175 people
- Sponsor
- PS Therapy Inc.
Myopia, Dry Eye Disease (DED)
Study of Eye Fatigue From Digital Screens and Its Impact on Visual Performance in People With Normal Vision and Myopia, With and Without Dry Eye Symptoms and Signs
The goal of this observational study is to investigate the effects of eye fatigue induced by screen task on dry eye disease (DED) signs and symptoms, visual performance, and visual behavior in young adults with and without DED…
- Trial name
- RReye (NCT07844408)
- Testing
- Eye Exams, Ocular Biometry and Aberrometry, Wearing a Smartwatch
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Essilor International
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Meibomian Gland Changes in Ocular Prosthesis Users
This observational cross-sectional study aims to evaluate meibomian gland loss and dry eye symptoms in patients using unilateral ocular prostheses.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Anophthalmic Socket Syndrome, Ocular Prostheses
- Trial name
- MGPRO (NCT07621952)
- Testing
- Oculus Keratograph 5M
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Age-Related Macular Degeneration
A Masked, Placebo-controlled Study to Assess Iptacopan in Age-related Macular Degeneration
The purpose of this study is to assess the effect of Iptacopan to prevent conversion of early or intermediate age-related macular degeneration (AMD) eyes to new incomplete retinal pigment epithelium and outer retinal atrophy…
- Trial name
- NCT05230537
- Testing
- Iptacopan (LNP023)
- Where
- 28 sites in United States, China and 2 more
- Volunteers
- 168 people
- Sponsor
- Novartis Pharmaceuticals
Ocular Pain, Dry Eye Syndrome
Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain
The aim of this pilot study is to compare the analgesic effect of SYL1001 versus placebo in patients with ocular pain associated with Dry Eye Syndrome. General and local tolerability are also evaluated.
- Trial name
- NCT01776658
- Testing
- SYL1001
- Where
- 3 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Sylentis, S.A.