Clinical trials: Dry Eyes
Dry Eye
Efficacy of FreshKote and Systane for the Treatment of Dry Eye and Improvement of Osmolarity
The purpose of this study is to compare the efficacy of FreshKote and Systane for the reduction of dry eye signs and symptoms.
- Trial name
- NCT01386073
- Testing
- FreshKote, Systane
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Treatment of Dry Eye Disease
Objective Measurements of Prolonged Effects of Restasis on Dry Eye Disease
We propose to investigate the response to Restasis, over a prolonged period of time in heavy computer users with dry eye disease.
- Trial name
- NCT00567177
- Testing
- Restasis, Refresh Plus
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Ocular Pain, Dry Eye
Study to Evaluate the Ocular Tolerance of SYL1001 in Healthy Volunteers
The purpose of this study is to determine whether SYL1001 is safe for the prevention and treatment of ocular pain and dry eye syndrome.
- Trial name
- NCT01438281
- Testing
- SYL1001
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Eye Dryness
Comparison of Two Marketed Lenses in a Controlled Environment
This study is comparing two silicone hydrogel contact lenses in a controlled environment for identification of characteristics associated to vision.
- Trial name
- NCT02212301
- Testing
- senofilcon A, lotrafilcon B
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye Syndromes
Lifitegrast Eye Drops in Healthy Subjects：Phase I Study
This is a single-center, randomized, double-blind, single-dose, two-period crossover Phase I clinical trial designed to: Compare the pharmacokinetic (PK) profiles of Lifitegrast Ophthalmic Solution and Xiidra® in plasma and tears…
- Trial name
- NCT07040826
- Testing
- Xiidra, Lifitegrast
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Dry Eye Syndromes
Effects of a Moisturizing Product on Dry Eye and Skin
Dry eye is a common syndrome associated with symptoms of dryness, burning, itching and grittiness of eyes. The objective of this study is to investigate the effects of a moisturizing product in liquid formula on symptoms and…
- Trial name
- SDE (NCT02683382)
- Testing
- Moisturizing Eye Product in Liquid Formula
- Where
- Finland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Petra Larmo
Dry Eye Syndromes
Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms
The purpose of this study is to evaluate and compare the effects of Altaire Gel forming solution and Refresh Tears in mild-moderate dry eye patients.
- Trial name
- NCT01382810
- Testing
- Altaire Gel forming solution, Refresh Tears
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovative Medical
Accommodation Disorder, Keratoconus
Clinical Investigation for a Multifunction Ophthalmic Measurement Device
The purpose of this clinical investigation is to evaluate the clinical utility of a multifunctional measuring device for Ophtalmology.
- Conditions
- Accommodation Disorder, Keratoconus, Dry Eye, Refractive Errors
- Trial name
- NCT06565091
- Testing
- Measurements of physiological parameters of the anterior chamber, Measurements of the Axial biometry
- Where
- France
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Essilor International
Dry Eye Syndromes
An Open-Label, Multi-Center, Clinical Study Evaluating the Effect of the NDE L68 StableFit® Punctal Plug on the Tear Lake
To evaluate the effect of the NDE L68 StableFit® punctal plug on the tear lake.
- Trial name
- NCT04280653
- Testing
- NDE L68 StableFit® Punctal Plug
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mati Therapeutics Inc.
Dry Eye
An Evaluation of the Clinical Utility and Safety of the Visant Medical Canalicular Plug
This study is designed to evaluate the clinical utility and safety of the Visant Medical Canalicular Plug compared to a commercially available canalicular plug.
- Trial name
- NCT04817085
- Testing
- Visant Medical Canalicular Plug, Commercially available canalicular plug
- Where
- 5 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Visant Medical, Inc.
Dry Eye Disease, Immunity
Efficacy of Twinkle Eyez Supplementation in Improving Ocular Health and Immunity
This is a randomised, double-blind, placebo-controlled study that recruited 110 participants. The objectives of this study are to determine the dietary intake levels of lutein and zeaxanthin among precipitants.
- Trial name
- NCT06574685
- Testing
- Twinkle Eyez Supplementation
- Where
- Malaysia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ecolite Group
Dry Eye Disease, Dry Eye
Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye
Prospective, multicenter, randomized, vehicle-controlled, double-masked, study of CAM-101 topical ophthalmic solution compared to vehicle control followed by crossover to long-term follow-up open-label treatment with CAM-101 for…
- Conditions
- Dry Eye Disease, Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- CAMOMILE-2 (NCT06903611)
- Testing
- CAM-101, Vehicle Control
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Cambium Bio Limited
Dry Eye Syndromes
Pharmacokinetics, Safety, and Tolerability of rhEGF Eye Drops in Healthy Male Subjects
A randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study of the Pharmacokinetics, safety, and tolerability of rhEGF eye drops in healthy male subjects
- Trial name
- NCT05219461
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Daewoong Bio Inc.
Dry Eye Disease, Ocular Surface Disease
Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Ofteno PF
This is a phase I study evaluating safety and tolerability of PRO-229 ophthalmic solution through he incidence of unexpected adverse events, changes in Best Corrected Visual Acuity (BCVA), incidence of chemosis, and changes in…
- Trial name
- NCT06370585
- Testing
- PRO-229, Lagricel® Ofteno PF
- Where
- Mexico
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye Syndromes
Safety Study of OPC-12759 Ophthalmic Solution
The purpose of this study is to assess the safety of OPC-12759 ophthalmic solution in healthy subjects.
- Trial name
- NCT01471093
- Testing
- OPC-12759 Ophthalmic solution, OPC-12759 Ophthalmic suspension
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dry Eye
Acute Comfort and Blur of Systane and Optive
To evaluate drop comfort, acceptability, preference and blur profile between two marketed artificial tears in both dry eye and non-dry eye patient population.
- Trial name
- NCT00568386
- Testing
- Systane Lubricant Eye Drops, Optive Lubricant Eye Drops
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye
A Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of RC017 Ophthalmic Ointment Following Single and Multiple Doses in Healthy Adult Participants
This is a Single-Center, Randomized, Double-Blind, Placebo-Controlled Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of RC017 Ophthalmic Ointment Following Single and Multiple Doses in Healthy…
- Trial name
- NCT07521748
- Testing
- RC017 Ophthalmic Ointment
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nanjing Reju Therapeutics Co., Ltd
Dry Eye Disease
Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye
The clinical investigation was intended to investigate the efficacy, ocular tolerability and safety of Vizol S Lipid Balance, a new eye drops, emulsion developed by JADRAN - GALENSKI LABORATORIJ d.d., in patients with moderate to…
- Trial name
- NCT06323395
- Testing
- Vizol S LIPID BALANCE eye drops, ophthalmic saline eye drops
- Where
- 2 sites in Serbia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Jadran Galenski laboratorij d.d.
Dry Eye Disease
Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and vehicle）and 0.1% sodium hyaluronate ophthalmic…
- Trial name
- NCT00760045
- Testing
- Hydroxypropyl Guar Galactomannan, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Healthy, Dry Eye
Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without…
- Trial name
- NCT00743249
- Testing
- MINI MONOKA canalicular stent, 10 mm, MINI MONOKA canalicular stent, 20 mm
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research