Clinical trials: Dry Eyes Chronic
Dry Eye Syndromes
Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms
- Trial name
- EXOIUMS (NCT06543667)
- Testing
- Limbal Stem Cell Derived Exosomes Eye Drop
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Iran University of Medical Sciences
Meibomian Gland Dysfunction, Posterior Blepharitis
Efficacy of Zylet vs. Lotemax for the Treatment of Ocular Surface Inflammation/MGD/Blepharitis
This is a Phase IV, single site, randomized, double masked, parallel control clinical trial of 60 subjects to investigate the variance of efficacy between Lotemax® and Zylet® for treatment of ocular surface inflammation due to…
- Trial name
- ZvL (NCT01456780)
- Testing
- Loteprednol/tobramycin, Loteprednol, B+L Advanced Eye Relief Lubricant Drop
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Dry Eye, Eye Diseases
Autologous Serum Tears With Hyaluronate vs Balanced Salt Solution for Moderate-to-Severe Dry Eye
This study aims to find out whether adding sodium hyaluronate, a moisturizing ingredient commonly found in artificial tears, makes autologous serum eye drops more effective for treating moderate-to-severe dry eye disease.
- Conditions
- Dry Eye, Eye Diseases, Eyes Dry Chronic
- Trial name
- NCT07413172
- Testing
- Autologous Serum Tears (50% Autologous Serum Tears + 0.2% Sodium Hyaluronate), Biological - Autologous Serum Tears (50% Autologous Serum Tears + Balanced Saline Solution (BSS), Standard of Care (SOC) Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Fibromyalgia, Multiple Sclerosis
e-Mobile Tablet for People With Chronic Conditions
Maintaining a healthy diet and engaging in routine physical activity may help decrease severity of symptoms, prevent secondary conditions, and slow functional decline in people with disabling neuromusculoskeletal conditions.
- Conditions
- Fibromyalgia, Multiple Sclerosis, Osteoarthritis, Sjögren's Syndrome
- Trial name
- NCT02833311
- Testing
- Computer Tablet Group, Paper and Pencil Group, Contact Control Group
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Case Western Reserve University
Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism
Study of Leukocyte Populations in Patients With Chronic Inflammatory
Exploration of pathophysiological mechanisms in chronic inflammatory rheumatism and rare systemic autoimmune diseases with the objective of identifying therapeutic targets.
- Conditions
- Systemic Autoimmune Disease, Chronic Inflammatory Rheumatism, Sjogren's Syndrome, Spondyloarthritis
- Trial name
- LIMA (NCT04749875)
- Testing
- blood sample
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dry Eyes Chronic
Intense Pulsed Light Study for Dry Eye Disease
This study will evaluate the efficacy of intense pulsed light (IPL) therapy for the treatment of dry eye disease. One eye of the participant will be randomized to receive the IPL treatment.
- Trial name
- NCT03089580
- Testing
- Intense Pulsed Light Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
Dry Eye Disease
Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC Study)
The objective of this study is to evaluate the chronic safety and effectiveness of OC-01 Nasal Spray as compared to placebo on signs of dry eye disease (DED).
- Trial name
- NCT03873246
- Testing
- OC-01 0.1% 0.6 mg/ml, OC-01 (varenicline) nasal spray: 0.2 % (1.2 mg/ml)
- Where
- Mexico
- Volunteers
- 123 people
- Sponsor
- Oyster Point Pharma, Inc.
Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes
CDL Validation Study
Ocular surface photography is significantly limited in standardization and reproducibility. This reduces its applicability for clinical monitoring of acute or chronic disease.
- Conditions
- Eyes Dry Chronic, Chronic Conjunctivitis of Both Eyes, Limbal Stem-cell Deficiency, Eye Lesion
- Trial name
- NCT05461469
- Where
- Austria
- Volunteers
- 104 people
- Sponsor
- Occyo GmbH
Systemic Lupus Erythematosus, Sjögren's Disease
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
The purpose of this study is to evaluate the safety and tolerability of BMS-986553, CD19 in vivo Chimeric Antigen Receptor (CAR) T cells, in participants with refractory autoimmune diseases including systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Sjögren's Disease, Rheumatoid Arthritis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07873931
- Testing
- BMS-986553
- Where
- 23 sites in United States, Belgium and 4 more
- Volunteers
- 60 people
- Sponsor
- Bristol-Myers Squibb
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Eyes Dry Chronic
ESBA105 in Patients With Severe Dry Eye
The purpose of this study was to evaluate the efficacy of ESBA105 over vehicle in reducing the ocular symptoms of dry eye disease, as measured by a mean global Visual Analog Scale (VAS) discomfort score.
- Trial name
- NCT01338610
- Testing
- ESBA105 ophthalmic solution, ESBA105 vehicle
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Alcon Research
Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis
This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
- Conditions
- Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum, Sjogren Syndrome, Mucous Membrane Pemphigoid
- Trial name
- NCT03839069
- Testing
- minor salivary gland transplantation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease
The goal of this prospective, open, monocentric study is to evaluate the clinical efficacy of a new preservative-free combination of trehalose, sodium hyaluronate and NAAGA in 30 patients with chronic dry eye disease and…
- Trial name
- NCT07007702
- Testing
- T2769
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Dry Eye, Dry Eyes Chronic
Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.
This is a phase I clinical study to evaluate the safety and tolerability of PRO-190 ophthalmic solution through the incidence of unexpected adverse events, changes in Best Corrected Visual Acuity (BCVA), changes in ocular surface…
- Conditions
- Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes
- Trial name
- NCT06379685
- Testing
- PRO-190, Systane Ultra®
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye, Dry Eyes Chronic
Switching From Xiidra to TRYPTYR
To determine the efficacy of switching participants who are being treated with Xiidra to acoltremon 0.003%. Hypothesis: Switching to acoltremon 0.003% will greatly improve the signs and symptoms of participants who were being…
- Conditions
- Dry Eye, Dry Eyes Chronic, Dry Eye Syndromes, Eye Diseases
- Trial name
- NCT07267481
- Testing
- acoltremon 0.003%
- Volunteers
- 100 people
- Sponsor
- Southern College of Optometry
Stevens-Johnson Syndrome
Efficacy of 0.05% Cyclosporin Eye Drop in Stevens Johnson Syndrome Patient With Chronic Dry Eye
The purpose of this study is to evaluate the efficacy of 0.05% cyclosporin ophthalmic emulsion (Restasis) in patients with Stevens-Johnson syndrome that have dry eyes by subjective symptoms and signs.
- Trial name
- NCT01488396
- Testing
- 0.05%cyclosporin eye drop
- Where
- Thailand
- Volunteers
- 31 people
- Sponsor
- Mahidol University
Dry Eye
Efficacy of the Chronic Application of Tear Formulations
The purpose of this study is to determine the therapeutic effect of the chronic application of eye-drops on tear evaporation rate in dry eye and normal subjects exposed to a condition of environmental stress.
- Trial name
- NCT01384851
- Testing
- Next Generation Emulsion, Refresh Dry Eye Therapy, Refresh Contacts
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Glasgow Caledonian University
Dry Eye Disease, Retinal Nerve Fiber Layer
Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers
This study aimed to examine the impact of long-term smoking on dry eye parameters and retinal nerve fiber layer thickness in individuals who are chronic smokers.
- Conditions
- Dry Eye Disease, Retinal Nerve Fiber Layer, Chronic Smoking
- Trial name
- NCT07028736
- Testing
- Dry eye assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Eye Pain
Pilot Study of TENS for Ocular Pain
Approximately 20% of Veterans have a diagnosis of dry eye (DE) syndrome which is often accompanied by ocular pain that significantly impacts activities of daily living.
- Trial name
- NCT05531643
- Testing
- High frequency forehead TENS, Low frequency forehead TENS
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT07245836
- Testing
- Thealoz Total® Eye Drops, Laboratoires Thea, Clermont Ferrand, France
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna