Clinical trials: Dry Mouth
Alveolar Bone Loss
Ridge Preservation Following Tooth Extraction Using Two Mineralized Cancellous Bone Allografts
The study is a 2-arm, parallel-design, randomized, prospective clinical trial designed to examine histologic wound healing following ridge preservation using bone allograft that has been prepared by either freeze-drying or via a…
- Trial name
- NCT02515058
- Testing
- PUROS (Ridge Preservation bone grafting surgery), FDBA (Ridge Preservation bone grafting surgery)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Dry Mouth
A Pilot Study to Assess Dry Mouth Relief After Using an Experimental Mouth Rinse
The objective of this pilot study is to determine if an experimental mouth rinse and a marketed dry mouth rinse are more effective in relieving dry mouth compared to water.
- Trial name
- NCT04152642
- Testing
- Marketed Dry Mouth Rinse, Water control, Experimental Dry Mouth Rinse
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Sjögren's Syndrome
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sjögren's Syndrome
The purpose of the study is to evaluate the efficacy, safety, and tolerability of VIB4920 (formerly MEDI4920) in adult participants with Sjögren's Syndrome (SS).
- Trial name
- SS (NCT04129164)
- Testing
- VIB4920
- Where
- 62 sites in United States, Argentina and 10 more
- Volunteers
- 183 people
- Sponsor
- Amgen
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Dry Eye Syndromes, Sjogren's Syndrome
TrueTear in Sjogren's Disease Patients
The purpose of this study is to evaluate acute tear production produced by the intranasal tear neurostimulator in participants with Sjögrens syndrome and aqueous tear deficiency.
- Trial name
- NCT03719885
- Testing
- TrueTear Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dry Eye, Neuropathic Eye Pain
Azithromycin for Meibomian Gland Disease
This study aims to elucidate the effectiveness of oral azithromycin in treating symptomatic dry eye syndrome secondary to Meibomian gland dysfunction.
- Conditions
- Dry Eye, Neuropathic Eye Pain, Ocular Microbiome, Depression, Anxiety
- Trial name
- NCT03953118
- Testing
- Azithromycin Oral Product
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of California, San Francisco
Leukodystrophy, White Matter Disease
LeukoSEQ: Whole Genome Sequencing as a First-Line Diagnostic Tool for Leukodystrophies
Leukodystrophies, and other heritable disorders of the white matter of the brain, were previously resistant to genetic characterization, largely due to the extreme genetic heterogeneity of molecular causes.
- Conditions
- Leukodystrophy, White Matter Disease, 4H Syndrome, Adrenoleukodystrophy
- Trial name
- NCT02699190
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Children's Hospital of Philadelphia
Congenital Heart Block, Neonatal Lupus
Preventive Approach to Congenital Heart Block With Hydroxychloroquine
Women with antibodies to proteins called SSA/Ro and or SSB/La face a 2% chance of having a child with a life threatening heart condition regardless of whether they have very active lupus, are in remission, or have only vague…
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-Associated Heart Block
- Trial name
- PATCH (NCT01379573)
- Testing
- Hydroxychloroquine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- NYU Langone Health
Sjogren's Syndrome
Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention
The primary purpose of this study is to quantify the change in expression of biomarkers on the ocular surface of Sjogren's Syndrome participants after treatment with Maxidex.
- Trial name
- NCT00631358
- Testing
- Maxidex, No treatment
- Where
- 2 sites in Canada
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Xerostomia
Clinical Evaluation of Oral Rinse for Xerostomia
Xerostomia causes a difficulty in eating, have irritated oral tissues, and a poor quality of life. The new oral rinse was designed to reduce the symptoms and improve the patient's quality of life.
- Trial name
- NCT04289051
- Testing
- HYDRAL Oral Rinse, BIOTENE® Oral Rinse
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Sunstar Americas
Xerostomia, Sjogren Syndrome
Green Tea Lozenges for the Management of Dry Mouth
The goal of this proposal is to investigate the effectiveness of a Medical College of Georgia patent pending formulation of natural plant extracts on patients with xerostomia.
- Conditions
- Xerostomia, Sjogren Syndrome, Dry Mouth
- Trial name
- NCT01647737
- Testing
- MighTeaFlow, Xylitol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Xerostomia
Trial of Parotid Sparing Whole Brain Radiation
The purpose of this study is to evaluate the efficacy of parotid sparing in reducing measurable xerostomia (dry mouth) in patients undergoing whole brain radiotherapy.
- Trial name
- NCT03595878
- Testing
- Parotid sparing WBRT, Standard WBRT
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Chewing Gum, Hemodialysis
Effect of Chewing Gum in Hemodialysis Patients
The aim of this prospective randomized controlled study was to investigate the effects of chewing gum on interdialytic weight gain, thirst, dry mouth and intradialytic symptoms in hemodialysis patients.
- Trial name
- NCT04142216
- Testing
- Chewing Gum
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul Demiroglu Bilim University
Xerostomia
Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects
The purpose of this study is to investigate the consumer perception of an experimental mouthwash formulation in population with dry mouth
- Trial name
- NCT03005041
- Testing
- Biotene mouthwash, Bottled mineral water
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye
Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease
The goal of this research is to determine if the Tangible Boost system adequately replenishes the Hydra-PEG coating on the surface of a rigid contact lens.
- Conditions
- Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye, Sjogren's Syndrome, Dry Eye
- Trial name
- NCT04313725
- Testing
- Tangible Boost
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Tangible Science
Xerostomia
Effect of Korean Red Ginseng (KRG) on Dry Mouth
The purpose of this study is to determine the effect of KRG (Korean Red Ginseng) on Dry Mouth (Xerostomia).
- Trial name
- NCT00911768
- Testing
- Korean Red Ginseng Powder Capsule, Corn-starch powder with ginseng flavor
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Ginseng
Chemotherapeutic Agent Toxicity, Mucositis
Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy
This randomized phase II trial is studying how well selenomethionine (SLM) works in reducing mucositis in patients with locally advanced head and neck cancer who are receiving cisplatin and radiation therapy.
- Conditions
- Chemotherapeutic Agent Toxicity, Mucositis, Radiation Toxicity, Stage III Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT01682031
- Testing
- selenomethionine, cisplatin, radiation therapy
- Where
- 2 sites in United States, New Zealand
- Volunteers
- 18 people
- Sponsor
- Roswell Park Cancer Institute
Periodontal Diseases
Regenafil Versus Demineralized Freeze Dried Bone Allograft (DFDBA) for Periodontal Defects
The purpose of this research study was to determine whether treatment with the bone grafting material Regenafil was as effective as the standard treatment using demineralized freeze dried bone allograft (DFDBA).
- Trial name
- NCT00255970
- Testing
- DFDBA, Regenafil
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RTI Surgical
Xerostomia, Head and Neck Cancer
Blinded Dry Mouth Spray Crossover Study
To identify the effectiveness of two mouth sprays at relieving symptoms of xerostomia in patients who have received radiation for carcinoma of the head and neck.
- Conditions
- Xerostomia, Head and Neck Cancer, Xerostomia Following Radiotherapy
- Trial name
- NCT04608773
- Testing
- Remineralizing Extreme Dry Mouth Spray with Xylitol, Alcohol-Free Moisturizing Dry Mouth Spray
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- Jonas Johnson
Dry Mouth, Xerostomia
Clinical Evaluation of MucoPEG™ for Xerostomia
The purpose of this study is to evaluate the effectiveness of the oral rinse comparing to MucoPEG™ and Biotene®. This is a randomized open-label crossover study with 42 patients receiving treatment.
- Trial name
- CEMPEG (NCT04986501)
- Testing
- MucoPEG, Biotene
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- SunBio, Inc.