Clinical trials: Dryness of Mouth
Dry Mouth
Bioequivalency Study of 7.5 mg Pilocarpine Under Fed Conditions
The objective of this study was the bioequivalence of a Roxane Laboratories' Pilocarpine tablets, 7.5 mg, to SALAGEN® Tablets, 7.5 mg (MGI) under fed conditions using a single-dose, randomized, 2-treatment, 2-period, 2-sequence…
- Trial name
- NCT00618059
- Testing
- Pilocarpine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Sjogren's Syndrome, Xerostomia
Pilot Study of Thalidomide to Treat Sjogren's Syndrome
This study will evaluate the safety and effectiveness of thalidomide in treating Sjogren's syndrome. In this autoimmune disease, the immune system attacks the body's tear glands and salivary glands, causing dry mouth and dry…
- Trial name
- NCT00001599
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Hypertension, Coronary Artery Disease
Amlodipine Freeze-Dried Powder for Oral Solution 5 mg
The goal of this clinical study is to assess the relative bioavailability of Amlodipine for Oral Solution 5 mg of Brillian Pharma Inc.
- Trial name
- NCT05808725
- Testing
- Amlodipine Freeze-Dried Powder for Oral Solution 5 mg, Norvasc 5 mg tablets of Pfizer Labs
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brillian Pharma Inc.
SARS-CoV Infection, Systemic Disease
Serologic Profile of SARS CoV2 in COVID-19 Patients With Systemic Diseases
An observational study aiming to assess the serological profile of SARS-Cov2 patients with systemic diseases such as systemic lupus erythematosus, Sjogren syndrome, sarcoidosis, inflammatory myopathies, Behçet's disease…
- Conditions
- SARS-CoV Infection, Systemic Disease, Systemic Lupus Erythematosus, Sjogren's Syndrome
- Trial name
- NCT04530461
- Testing
- Serological test
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- faida agili
Xerostomia
Effect of Korean Red Ginseng (KRG) on Dry Mouth
The purpose of this study is to determine the effect of KRG (Korean Red Ginseng) on Dry Mouth (Xerostomia).
- Trial name
- NCT00911768
- Testing
- Korean Red Ginseng Powder Capsule, Corn-starch powder with ginseng flavor
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Ginseng
Sjogrens Syndrome
A Study of Flt3-Ligand Levels in Sjögrens Syndrome
The study aims to correlate levels of Flt3-ligand in Cerebrospinal Fluid (CSF) and serum to markers for inflammation and degeneration in patients with primary Sjogrens syndrome.
- Trial name
- NCT01470638
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Göteborg University
Xerostomia, Sjogren's Syndrome
Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome
The purpose of this study is to exploratively investigate the clinical efficacy of rebamipide on dry mouth in patients with Sjögren's syndrome in comparison with placebo.
- Trial name
- NCT00233363
- Testing
- Rebamipide
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Periodontal Pocket, Xerostomia
Periodontal Outcomes After Sanative Therapy
Salivary gland hypofunction, or dry mouth, is a damaging oral condition that affects salivary gland production. Absence of saliva causes bad breath, dental decay, increased plaque accumulation, dry lips, mouth sores, and the…
- Conditions
- Periodontal Pocket, Xerostomia, Dry Mouth, Periodontal Diseases
- Trial name
- NCT03649789
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Brock University
Xerostomia, Sjogren's Syndrome
Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome
The purpose of this study is to evaluate the effectiveness of NGX267 in the improvement of decreased salivary flow associated with primary or secondary Sjögren's syndrome.
- Trial name
- NCT00637793
- Testing
- NGX267
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- TorreyPines Therapeutics
Sjogren's Syndrome
Study of Iguratimod in Sjögren's Syndrome
A single-center, self-control, open-label study of efficacy and safety of Iguratimod in patients with Sjögren's Syndrome
- Trial name
- NCT03023592
- Testing
- Iguratimod
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Sjögren's Syndrome, Sjogren's Syndrome
Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS)
Primary Objective: To evaluate the therapeutic efficacy of one dose level of SAR441344 versus placebo over 12 weeks in adult patients with primary Sjögren's syndrome (pSjS), assessed by the change of the European League Against…
- Trial name
- phaethuSA (NCT04572841)
- Testing
- SAR441344
- Where
- 36 sites in United States, Argentina and 10 more
- Volunteers
- 84 people
- Sponsor
- Sanofi
Sjögren's Syndrome
Low-dose Interleukin-2 and Rapamycin on sjögren's Syndrome
The purpose of this paper is to analysis of therapeutic effect and immunological mechanism of low-dose IL-2 combined with rapamycin in the treatment of Sjogren's syndrome
- Trial name
- NCT05605665
- Testing
- low-dose interleukin-2, rapamycin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Dry Eye Syndrome, Sjogren's Syndrome
Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome
This study combines data from two trials testing acupuncture (ACUDES) and a Chinese herbal tea bag TBDESJS for Dry Eye Syndrome and Sjögren's syndrome. Both treatments improved tear production.
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06475027
- Testing
- TBDESJS, Acupuncture
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Dry Eye Syndromes
Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye
The purpose of this study is to determine the safety and efficacy of Limbal Stem Cells derived Exosomes (LSC-Exo) in alleviation of dry eye symptoms
- Trial name
- EXOIUMS (NCT06543667)
- Testing
- Limbal Stem Cell Derived Exosomes Eye Drop
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Iran University of Medical Sciences
Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery
Does Craniosacraltherapy Combined With Exercises That Focuses om Respiration and Posture in the Upper Body Have an Effect on Xerostomia and Other Late Sequelae on People Who Has Been Suffering From Cancer in Mouth and Throat?
The current study aims to assess the efficacy of manual treatment with craniosacral therapy of fascial tissue in throat, neck, cranial and mouth region, on radiation and/or surgery-induced salivary gland hypofunction and…
- Conditions
- Xerostomia Following Radiotherapy, Xerostomia Following in Neck or Head After Cancer Surgery, Other Late Sequelae Following Radiotherapy and Cancer Surgery in Neck or Head
- Trial name
- NCT05882890
- Testing
- Craniosacral Therapy, Exercices Targeting Upper Posture and Respiration
- Where
- 2 sites in Denmark
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Cathrine Rahbek
Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis
Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases
Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.
- Conditions
- Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis, Takayasu Arteritis, Giant Cell Arteritis
- Trial name
- NAREG (NCT05904301)
- Testing
- Usual medical management of patients, additional blood and stool samples for biobanking
- Where
- 6 sites in Armenia
- Volunteers
- 800 people
- Sponsor
- Santé Arménie French-Armenian Research Center
Dry Eye, Sjogren Syndrome
Platelet -Rich Plasma (PRP) Injection for the Treatment of Severe Dry Eye
Dry eye is a chronic condition that decreases function and affect visual function with severe discapacity until now treatments are based in artificial eye drops.
- Trial name
- NCT02257957
- Testing
- PRP injection, Standard care Hyaluronic acid eye drops
- Volunteers
- 30 people
- Sponsor
- Universidad Nacional de Colombia
Dry Mouth
Crossover Bioequivalence Study of Cevimeline 30 mg Capsules Under Fed Conditions
The objective of this study was to prove the bioequivalence of Roxane Laboratories' Cevimeline 30 mg under fed conditions
- Trial name
- NCT01903109
- Testing
- Cevimeline
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Tooth Loss
Comparison of Straumann BoneCeramic vs. Allograft Bone in Extraction Sockets
The primary objective of this study is to evaluate the implant stability at the time of abutment placement on implants placed in healed extraction sockets treated with Straumann BoneCeramic (SBC) versus Freeze Dried Bone…
- Trial name
- NCT00782236
- Testing
- Bone Graft Material
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Institut Straumann AG
Xerostomia
Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications.
Dry mouth symptoms mostly occur as drug side-effects. Available products such as saliva substitutes are disappointing (bad taste, poor efficiency).
- Trial name
- LactoXeros (NCT02705937)
- Testing
- Dairy product, Aequasyal mouth spray
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon