Clinical trials: Dryness of Mouth
Hepatitis C Virus
Bioavailability Study Of PF-00868554 Administered As 3x250mg Oral Tablets (Wet Granulate, 3x250mg Oral Tablets (Dry Granulate) And 750mg Solution Under Fed State
This study will test two different formulations. The results will be used to select formulation for phase 3.
- Trial name
- NCT00861458
- Testing
- Pharmacokinetics
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alveolar Osteitis
Clinical Investigation of the Efficacy of CGF and Ozone in the Treatment of Alveolar Osteitis
The aim of this study is to investigate the efficacy of CGF and Ozone in the treatment of alveolitis and to develop a new treatment protocol that can enable a quick and effective solution of this clinical problem, which…
- Trial name
- NCT04507009
- Testing
- Ozone, CGF, Traditional treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ordu University
Dry Mouth, Halitosis
Effect of Wearing Face Masks on Salivary Parameters and Halitosis
During the current COVID-19 pandemic, the use of face masks is recommended / mandatory to prevent infection. Patients and students have reported to experience limitations in their oral health-related quality of life, especially…
- Trial name
- NCT04914208
- Testing
- DIY face mask, Surgical face mask, FFP2 respirator mask
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Göttingen
Sjogren's Syndrome, Autoimmune Diseases
Examining the Immunological Process of Autoimmune Patients
Sjögren's syndrome (SjS) is an autoimmune disease characterized primarily by exocrine gland dysfunction, specifically of the salivary and lacrimal glands, resulting in dry mouth and dry eyes symptoms.
- Conditions
- Sjogren's Syndrome, Autoimmune Diseases, Dry Eyes, Dry Mouth
- Trial name
- NCT02123147
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
ANCA Associated Vasculitis, Sjogren's Syndrome
Patients With Co-occurrence of ANCA Vasculitis and Sjögren Syndrome
ANCA vasculitis and Sjögren syndrome are two rare diseases, and even more rarely associated. These two conditions have specific organ involvements, and specific follow-up.
- Trial name
- NCT04895878
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Radiation-induced Xerostomia
Hyperbaric Oxygen for the Treatment of a Dry Mouth Which Occurred After Radiotherapy
The purpose of this study is to determine whether hyperbaric oxygen is effective in the treatment of a dry mouth that occured after radiotherapy for head and neck tumours.
- Trial name
- NCT00682747
- Testing
- Hyperbaric oxygen
- Where
- 2 sites in Germany
- Volunteers
- 13 people
- Sponsor
- Thomas Kuhnt
Dry Socket
Prevention of Dry Socket by Means of Single Preoperative Antibiotics Compared to Conventional Therapy
Background: One of the commonest post-operative complications after tooth extraction is dry socket; it can be defined as postoperative pain in and around the tooth extraction site, which increases in severity at any time between…
- Trial name
- NCT03992144
- Testing
- Amoxicillin 500 Mg, metronidazole 400mg, metronidazol 400mg and amoxicillin 500mg
- Where
- Pakistan
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Sjögren's Syndrome
SS-INQ Information Needs Questionnaire in Sjögren's Syndrome
Patients with some long-standing rheumatic diseases have stated that they want to be fully informed about their disease as they find it 'more scary not to know' about possible complications and consequences.
- Trial name
- SS-INQ (NCT04798911)
- Testing
- Phase 1 Observational Interviews
- Where
- United Kingdom
- Volunteers
- 243 people
- Sponsor
- University College, London
Xerostomia, Polypharmacy
Treatment of Salivary Gland Hypofunction With Neuro- Electrostimulation
The objective of the study is to evaluate with clinical parameters the performance of Saliwell Crown as a neuro-electrostimulator of the submandibular and sublingual salivary glands in hypofunction status due to polypharmacy or…
- Conditions
- Xerostomia, Polypharmacy, Sjögren's Syndrome
- Trial name
- SALELECTROSTIM (NCT01174329)
- Testing
- Automatic neuro-electrostimulation by "Saliwell Crown", Patient-regulated neuro-electrostimulation by "Saliwell Crown"
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Sjögren's Syndrome
Efficacy and Safety of Abatacept in Patients With Primary Sjögren's Syndrome
Primary Sjögren's syndrome (pSS) is a common chronic auto-immune disease, characterised by inflammation of the exocrine glands, resulting in progressive dryness of the eyes and the mouth.
- Trial name
- ASAPIII (NCT02067910)
- Testing
- Abatacept SC
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Sjögren's Syndrome, Xerostomia
Dexamethasone Irrigation of the Parotid Glands in Primary Sjögren's Syndrome Subjects
Background: Sjögren's syndrome is an autoimmune disease (where the immune system attacks normal body tissues) that affects the salivary glands.
- Trial name
- NCT01316770
- Testing
- Dexamethasone Parotid Irrigation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Keratoconjunctivitis Sicca
Trial of CF101 to Treat Patients With Dry Eye Disease
Eligible patients with dry eye will be treated with CF101 or placebo twice daily for 24 weeks. Disease activity will be assessed using evaluations of ocular surface integrity, tear production, and patient symptoms.
- Trial name
- NCT01235234
- Testing
- CF101
- Where
- Israel
- Volunteers
- 236 people
- Sponsor
- Can-Fite BioPharma
Autoimmune Disease, Crohn Disease
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
This phase Ib trial studies the side effects of nivolumab and to see how well it works alone and in combination with other treatments, such as ipilimumab, cabozantinib, platinum containing therapy, and fluoropyrimidine, in…
- Conditions
- Autoimmune Disease, Crohn Disease, Dermatomyositis, Hematopoietic and Lymphoid Cell Neoplasm
- Trial name
- NCT03816345
- Testing
- Biospecimen Collection, Cabozantinib, Fluoropyrimidine
- Where
- 52 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- National Cancer Institute (NCI)
Xerostomia, COVID-19
The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19.A Randomized Controlled Trial.
Coronavirus (COVID-19) is a newly emerging zoonotic agent that emerged in December 2019 in China (2019-nCoV) as a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV -2).
- Conditions
- Xerostomia, COVID-19, Long COVID, Persistent COVID-19
- Trial name
- NCT05760092
- Testing
- Institutional standard treatment for xerostomia and Long Covid, Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Nove de Julho
Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder)
Effect of Oral Isotretinoin on Ocular Surface and Meibomian Glands
The aim of the study was to evaluate meibomian gland morphology using non-contact meibography and ocular surface changes in patients with acne vulgaris treated with isotretinoin as indicators of dry eye, which is known to be a…
- Conditions
- Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder), Acne Vulgaris
- Trial name
- NCT07753811
- Testing
- isotretinoin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Postoperative Complications
Risk Factors Related to Thirst After Surgery
To investigate the risk factors related to xerostomia (dry mouth) after surgery
- Trial name
- NCT04900753
- Where
- Taiwan
- Volunteers
- 472 people
- Sponsor
- Chang Gung Memorial Hospital
Sjogren's Syndrome, Xerostomia
Pilot Study of Thalidomide to Treat Sjogren's Syndrome
This study will evaluate the safety and effectiveness of thalidomide in treating Sjogren's syndrome. In this autoimmune disease, the immune system attacks the body's tear glands and salivary glands, causing dry mouth and dry…
- Trial name
- NCT00001599
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Alveolar Osteitis
Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence
This intervention is the treatment of alveolar osteitis (alveolitis) with different effects, which occurs due to the formation of clot after extraction, which is one of the most common intervals after tooth extraction.98 healthy…
- Trial name
- NCT06435832
- Testing
- Absorbable Gelatin, Chlorhexidine, Tranexamic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Sjogren's Syndrome
Immune Profile of Saliva and Serum of Patients With Primary Sjögren´s Syndrome
Primary Sjögren's syndrome (pSS) is a chronic systemic inflammatory disease, which mainly affects the lacrimal and salivary glands, leading to sicca syndrome.
- Trial name
- pSS (NCT03711214)
- Testing
- Periodontal scaling
- Where
- 3 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital