Clinical trials: Ductus
Patent Foramen Ovale, Atrial Septal Defect
Lifetech CeraFlex™ Post-Market Surveillance Study
The purpose of this multi-center, non-interventional, prospective, post-market clinical study is to collect real world data on patient outcomes and evaluate the procedural success and performance of the Lifetech CeraFlex™…
- Conditions
- Patent Foramen Ovale, Atrial Septal Defect, Patent Ductus Arteriosus
- Trial name
- NCT02621528
- Testing
- CeraFlex
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 120 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Patent Ductus Arteriosus, Prematurity
Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure
The primary objective is to evaluate the Patent Ductus Arteriosus (PDA) closure rate of early vs. late use of Ibuprofen (Ibu). The investigators believe that early use of Ibu will have a higher PDA closure rate than later use of…
- Trial name
- NCT00833365
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Patent Ductus Arteriosus
PDA Post NICU Discharge
The purpose of this study is to track post-discharge outcomes on prematurely born infants who are discharged from the NICU with a patent ductus arteriosus (PDA).
- Trial name
- PDA (NCT02750228)
- Where
- 16 sites in United States
- Volunteers
- 208 people
- Sponsor
- Pediatrix
Intrauterine Growth Restriction (IUGR)
Ductus Venosus Doppler in IUGR Pregnancies
This prospective observational cohort study aims to evaluate the relationship between ductus venosus Doppler parameters and perinatal outcomes in pregnancies complicated by intrauterine growth restriction (IUGR).
- Trial name
- IUGR-DV (NCT07193381)
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- İlayda Gercik Arzık, MD
Patent Ductus Arteriosus, Infant, Premature
Ibuprofen vs Expectant Management for hsPDA in Preterm Infants: Retrospective Cohort
This retrospective cohort study compares ibuprofen treatment versus expectant management for hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants.
- Trial name
- IMPACT-PDA (NCT07533721)
- Testing
- Ibuprofen
- Where
- China
- Volunteers
- 541 people
- Sponsor
- Shengjing Hospital
Ductus Arteriosus, Patent
Plasma N-terminal proBNP Concentrations and Patent Ductus Arteriosus in Preterm Babies
Premature babies are affected by a condition known as "patent ductus arteriosus" in which the ductus arteriosus (a normal structure) fails to close after birth as it should.
- Trial name
- NCT00725647
- Volunteers
- 102 people
- Sponsor
- St George's, University of London
Patent Ductus Arteriosus, Circulation
Liver Regional Oxygen Saturation in Preterm Patent Ductus Arteriosus
This study evaluates the usefulness of liver perfusion and oxygenation status using regional oxygen saturation (RSO2) values obtained via near-infrared spectroscopy in assessing the hemodynamical significance of patent ductus…
- Conditions
- Patent Ductus Arteriosus, Circulation, Newborn Morbidity, Premature Birth
- Trial name
- NCT05639309
- Testing
- near-infrared spectroscopy based cerebral/somatic oximeter system (INVOS™ system manufactured by Medtronics)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul St. Mary's Hospital
Patent Ductus Arteriosus
Timing for the Medical Treatment of Patent Ductus Arteriosus in Preterm Infants
This is a retrospective chart review to look at the timing of using indomethacin and ibuprofen for PDA closure for infants admitted into the NICU of the University of Utah Hospital from 1/2007-8/2008.
- Trial name
- NCT00795990
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Utah
Congenital Heart Defect, Patent Ductus Arteriosus
Effect of PDA Closure on the Left Ventricular Remodeling
failure of closure of the ductus arteriosus after birth results in a congenital anomaly known as patent ductus arteriosus. The large ductus can induce left side heart remodeling changes which could interfere with the normal…
- Trial name
- NCT04964531
- Testing
- speckle tracking echocardiography
- Volunteers
- 48 people
- Sponsor
- Ahmed Mohamed Moheb El-Din
Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants
Oral Ibuprofen Prophylaxis for Patent Ductus Arterioses in Very Extremely Low Birth Weight Infants
Patent ductus arterioses (PDA) is a major morbidity in preterm infants, especially in extremely premature infants less than 28 weeks.
- Trial name
- OIP (NCT01400737)
- Testing
- ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Preterm Birth
Preterm birth still remains a major cause of perinatal morbidity and mortality worldwide. The exact mechanism stimulating term and preterm births in humans is still unknown.
- Trial name
- NCT03073512
- Testing
- Ultrasound examination
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Patent Ductus Arteriosus After Premature Birth
Indomethacin PK-PD in Extremely Preterm Neonates
This is a phase II open-label study evaluating the pharmacokinetics and pharmacodynamics of targeted early use of indomethacin for PDA treatment in preterm neonates <27 weeks' gestational age.
- Trial name
- INDO (NCT04025177)
- Testing
- Indomethacin Injection
- Where
- 2 sites in Canada
- Sponsor
- University of Manitoba
Ductus Arteriosus, Patent
Changes in Renal and Splanchnic Oxygenation During Ibuprofen Treatment for Patent Ductus Arterious
Patent ductus arterious(PDA)is frequently seen and potentially pathologic in preterm infants. Near-infrared spectroscopy is a simple bedside tool to analyse the changes in the renal and splanchnic tissue oxygenation index and…
- Trial name
- NCT01251939
- Testing
- Near-infrared spectroscopy (NIRS)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Fetal Growth Restriction, Perinatal Outcome
Relationship of DV Doppler Parameters to Perinatal Outcomes in IUGR vs Non-IUGR
This observational study investigates whether blood flow in the ductus venosus, a small fetal vein measured by Doppler ultrasound, is related to pregnancy outcomes.
- Conditions
- Fetal Growth Restriction, Perinatal Outcome, Pregnancy, High Risk
- Trial name
- DV-FGR (NCT07190157)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital
Ductus Arteriosus
The Role of Fetal Ductus Arteriosus in Predicting Spontaneous Labour at Term
The exact mechanism stimulating the parturition in humans is still relatively unknown. Prostaglandins, by mediating cervical ripening and early stimulation of myometrial contractions, are likely to play a major role in the…
- Trial name
- NCT03073460
- Testing
- Ultrasound examination
- Sponsor
- Unity Health Toronto
Left Ventricular Hypertrophy
Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects…
- Trial name
- SPEC (NCT04644094)
- Testing
- Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Intrauterine Growth Restriction, Small-for-gestational Age
Ultrasound Evaluation of Fetal Hemodynamics and Perinatal Complications
In case of fetal weight below the 10th centile for gestational age, it is important to distinguish SGA and IUGR. SGA is defined as a fetal weight below the 10th centile.
- Trial name
- PTI'DOP (NCT03865628)
- Volunteers
- 1,200 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Patent Ductus Arteriosus
Brain, Gut and Kidney Blood Flow During Medical Closure of PDA
The purpose of this study is to determine how the medications which are used to close the patent ductus arteriosus (PDA) in preterm infants affect brain, kidney and gut blood flow when compared to infants that are not treated…
- Trial name
- NCT00554307
- Testing
- INVOS Cerebral/Somatic oximeter
- Where
- United States
- Sponsor
- University of Louisville
Ductus Arteriosus, Patent
NIT-OCCLUD PDA Phase II Sentinel Trial
The purpose of this study is to evaluate the safety and efficacy of the Nit-Occlud -PDA Occlusion System for transcatheter closure of PDA with minimum angiographic diameter less than 4 mm, and to compare one year safety and…
- Trial name
- NCT00828334
- Testing
- Transcatheter PDA Coil
- Where
- 15 sites in United States
- Volunteers
- 357 people
- Sponsor
- PFM Medical, Inc
Patent Ductus Arteriosus
Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates
To compare the effectiveness of rectal vs. intravenous paracetamol in the medical treatment of significant PDA in neonates.
- Trial name
- NCT06256211
- Testing
- Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soha mahmoud Hussien mahdy