Clinical trials: Duloxetine
Depression, Bereavement
Cymbalta for Depression as a Complication of Bereavement
The primary objective of this pilot project is to evaluate the efficacy of Cymbalta for bereavement-associated depression. Participating patients will be treated with Cymbalta in doses up to 60mg daily for eight (8) weeks.
- Trial name
- NCT00658931
- Testing
- Drug treatment with Cymbalta
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jefferson Clinic, P.C.
Fibromyalgia
Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia
The objective of this study is to evaluate the safety, tolerability and efficacy of milnacipran in patients with an inadequate response to duloxetine for the treatment of fibromyalgia.
- Trial name
- NCT01077375
- Testing
- Milnacipran
- Where
- 26 sites in United States
- Volunteers
- 107 people
- Sponsor
- Forest Laboratories
Fibromyalgia Syndrome, Fibromyalgia
Effects of 2-Aticyto Complex and D-Ribose on Pain and Clinical Course in Patients With Fibromyalgia
This multicenter, randomized, double-blind, placebo-controlled study will evaluate whether an oral supplement containing 2-Aticyto Complex and D-ribose (FibroThol), added to ongoing standard medical treatment, improves pain…
- Trial name
- NCT07495943
- Testing
- 2-Aticyto Complex and D-ribose Oral Supplement
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Diabetic Neuropathy, Painful
A Study in Participants With Diabetic Peripheral Neuropathic Pain in China
The purpose of this trial is to assess the efficacy of duloxetine 60 milligrams (mg) once daily (QD) compared with placebo, on the change in pain severity from baseline to 12 weeks as measured by the weekly mean of the daily pain…
- Trial name
- NCT01179672
- Testing
- Duloxetine
- Where
- 15 sites in China
- Volunteers
- 405 people
- Sponsor
- Eli Lilly and Company
Post Operative Pain Control
Duloxetine and Dexamethasone for Improving Postoperative Pain
75 female patients were randomly allocated into one of three equal groups. Group I(GI) received Dulox 60 mg orally and 100 ml 0.9% sodium chloride solution (NS) intravenous infusion (IVI) over 15 min, group II(GII): received…
- Trial name
- NCT03250494
- Testing
- Dulox capsule (60mg), combined Dulox capsule (60 mg) orally and Dex 0.1mg/kg diluted in 100 ml 0.9% NS IVI
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Depression
The Effect of Duloxetine on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients
Primary tumor glioblastoma is the most common malignant brain. Standard treatment includes biopsy or excision of the tumor in order to obtain a pathological diagnosis, and tumor mass reduction.
- Trial name
- NCT02443194
- Testing
- duloxetine
- Volunteers
- 50 people
- Sponsor
- michal roll
Irritable Bowel Syndrome, Generalized Anxiety Disorder
An Open Label Trial of Duloxetine in the Treatment of Irritable Bowel Syndrome and Comorbid Generalized Anxiety Disorder
The investigators propose to evaluate the effectiveness of duloxetine in treating subjects with both Irritable Bowel Syndrome (IBS) and Generalized Anxiety Disorder (GAD).
- Trial name
- NCT00961298
- Testing
- Duloxetine
- Volunteers
- 17 people
- Sponsor
- West Penn Allegheny Health System
Diabetic Polyneuropathy, Postherpetic Neuralgia
Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin
Tramadol is an opioid analgesic, which is widely used in the treatment of acute and neuropathic pain. Treatment of neuropathic pain often requires a combination of pain medications due to the complex nature of neuropathic pain…
- Trial name
- NCT01116531
- Testing
- Tramadol, Duloxetine, Pregabalin
- Where
- Finland
- Sponsor
- Turku University Hospital
Drug Effect
Comparison of Duloxetine Versus Pregabalin
Chronic post mastectomy pain syndrome (PMPS) is a chronic post-surgical neuropathic pain following breast cancer surgeries and lasting more than three months after surgeries.
- Trial name
- NCT04727502
- Testing
- Duloxetine, Pregablin
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Egypt
Major Depressive Disorder
Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression
The Purposes of this Study are to determine: The safety of duloxetine and any side effects that might be associated with it. Whether duloxetine can help patients with major depression.
- Trial name
- NCT00042575
- Testing
- Duloxetine
- Where
- 9 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy
Painful diabetic peripheral neuropathy (DPN) is a frequent and disabling complication of diabetes that commonly causes persistent foot pain, sleep impairment, and decreased quality of life.
- Conditions
- Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy, Diabetic Foot Pain, Neuralgia
- Trial name
- NCT07882238
- Testing
- Botulinum Toxin Type A, Duloxetine
- Volunteers
- 56 people
- Sponsor
- Assiut University
Major Depressive Disorder
Randomised Placebo-controlled Duloxetine-referenced Efficacy and Safety Study of 2.5, 5 and 10 mg of Vortioxetine (Lu AA21004) in Acute Treatment of Major Depressive Disorder
The purpose of the study is to evaluate the efficacy and the tolerability of three fixed doses of Vortioxetine in order to establish the appropriate clinical effective dose range in the treatment of Major Depressive Disorder…
- Trial name
- NCT00635219
- Testing
- Vortioxetine (Lu AA21004), Duloxetine
- Volunteers
- 766 people
- Sponsor
- H. Lundbeck A/S
Osteoarthritis of the Knee
An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480)
The purpose of this study is to assess the safety and efficacy of duloxetine in participants with osteoarthritis and knee pain. The study will last for 1 year.
- Trial name
- NCT02335346
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 93 people
- Sponsor
- Eli Lilly and Company
Modified Radical Mastectomy, Postoperative Analgesia
Duloxetine for Postoperative Analgesia After Modified Radical Mastectomy
The aim of this study is to evaluate the role of duloxetine in controlling pain after radical mastectomy.
- Trial name
- NCT05442268
- Testing
- Acetaminophen group, Duloxetine group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Bioequivalence
Bioavailability of Duloxetine 60 mg With Regards to Reference Product in Feeding Conditions
This Study will investigate the bioavailability in fasting subjects of 1 capsule formulation containing Duloxetine 60 mg. The Study will be performed at a single site with 36 subjects.Participants will take 1 capsule of the test…
- Trial name
- NCT04751318
- Testing
- Duloxetine 60mg Test Drug Enteric Coated Granules, Duloxetine 60mg Reference Product Enteric Coated Granules
- Where
- Chile
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Laboratorios Andromaco S.A.
Painful Diabetic Peripheral Neuropathy
Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral Neuropathy
This study will evaluate the efficacy and safety of low-dose duloxetine combined with alpha-lipoic acid compared with standard-dose duloxetine in adults with painful diabetic peripheral neuropathy.
- Trial name
- NCT07785544
- Testing
- Duloxetine, Alpha-Lipoic Acid
- Where
- Bangladesh
- Volunteers
- 170 people
- Sponsor
- Bangladesh Medical University
Osteo Arthritis Knee
Efficacy of Duloxetine Compared to NSIADs in Osteoarthritis of Knee
Osteoarthritis (OA) is the most common degenerative joint disease, affecting more than 25% of the population . Knee OA is an insidious disease related to structural changes in the joint over many years.
- Trial name
- Duloxetine (NCT05486026)
- Testing
- Duloxetine 30 MG, Nonsteroidal Antiinflammatory Drug
- Where
- Iraq
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Major Depressive Disorder
Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial
The aim of this study was to investigate the effects of duloxetine on improvement of brain cortical activity in patients suffering from major depressive disorder using near infrared spectroscopy.
- Trial name
- NCT03121573
- Testing
- Duloxetine
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Pain
Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic Pain
Early stage breast cancer is typically treated with surgery, chemotherapy, radiation therapy, and/or endocrine therapy. Following treatment, 25-60% of breast cancer survivors have reported chronic pain, which can be difficult to…
- Trial name
- NCT01912612
- Testing
- Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan Rogel Cancer Center
Atypical Depression
A Pilot Study Assessing Duloxetine's Efficacy in Atypical Depression
This is a Pilot Study to get a first indication whether Duloxetine may be effective for depressed patients with Atypical Features.
- Trial name
- NCT00296699
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- New York State Psychiatric Institute