Clinical trials: Duodenal Adenomas
Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma
Testing Obeticholic Acid for Familial Adenomatous Polyposis
This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP).
- Conditions
- Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma, Duodenal Carcinoma, Familial Adenomatous Polyposis
- Trial name
- NCT05223036
- Testing
- Biopsy Procedure, Biospecimen Collection, Gastrointestinal Endoscopy
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Attenuated Familial Adenomatous Polyposis, Familial Adenomatous Polyposis
Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer
This phase II trial studies the side effects of erlotinib hydrochloride and how well it works in reducing duodenal polyp burden in patients with familial adenomatous polyposis at risk of developing colon cancer.
- Trial name
- NCT02961374
- Testing
- Erlotinib, Erlotinib Hydrochloride
- Where
- 8 sites in United States, Puerto Rico
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Familial Adenomatous Polyposes, Duodenal Polyposis
Endoscopic Evaluation of Duodenal Polyposis in Patients With Familial Adenomatous Polyposis (FAP)
Familial adenomatous polyposis (FAP) is an autosomal dominant genetic disorder that predisposes to a number or malignant disorders [1,2].
- Conditions
- Familial Adenomatous Polyposes, Duodenal Polyposis, Duodenal Cancer
- Trial name
- NCT03346980
- Testing
- Esophagogastroduodenoscopy
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Esophageal Cancer, Gastric Cancer
Diagnostic Performance Indicators in Upper GI Endoscopy:PROSPERO Study
Cancers of the upper gastro-intestinal tract, including esophagus (gullet), stomach and small bowel, are amongst the deadliest malignancies.
- Conditions
- Esophageal Cancer, Gastric Cancer, Barrett Esophagus, Gastric Atrophy
- Trial name
- PROSPERO (NCT04843397)
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Familial Adenomatous Polyposis
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)
- Trial name
- NCT04677998
- Testing
- Personalized surveillance and intervention protocol
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Polyps
Prevalence of Small Bowel Polyps in Patients With Sporadic Duodenal Adenomas
Little is known about the prevalence of small bowel polyps in patients with sporadic Duodenal/Ampullary polyps. The investigators aim to investigate the prevalence of small bowel polyps in patients with sporadic (ie not related…
- Trial name
- SPIDA (NCT02470416)
- Testing
- Small bowel video capsule endoscopy (VCE) GIVEN/COVIDIEN LTD
- Where
- Australia
- Volunteers
- 177 people
- Sponsor
- Western Sydney Local Health District
Prospective Study , Questionaires, Outcomes
Prospective Study To Assess The Outcomes Of Nitrous Oxide Cryoablation For Treatment Of Duodenal Adenomas In Patients With Hereditary Conditions Such As FAP, HNPCC
To learn how well nitrous oxide cryoballoon ablation, a procedure that uses extreme cold to destroy abnormal tissue, works in treating flat duodenal adenomas (abnormal growths in the small intestine) in people with FAP or Lynch…
- Conditions
- Prospective Study , Questionaires, Outcomes, Nitrous Oxide, Cryoablation
- Trial name
- NCT07859514
- Testing
- Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Duodenal Adenoma, Complication of Treatment
Effectiveness of Endoscopic Papillectomy With Stent for Treating Duodenal Papillary Adenoma
This is a retrospective study, including 79 patients with duodenal papillary adenoma, who treated with Endoscopic Papillectomy (EP) at Beijing friendship hospital.
- Trial name
- NCT06301048
- Testing
- Stent Placement in Pancreatic and Bile Ducts
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Beijing Friendship Hospital
Adenoma
Prophylactic Octreotide to Prevent Post Duodenal EMR and Ampullectomy Bleeding
Our hypothesis is that prophylactic administration of 5 days of Octreotide following EMR or ampullectomy in patients with duodenal and ampullary adenomas greater than or equal to 10mm.
- Trial name
- NCT02032784
- Testing
- octreotide, No Octreotide
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- AdventHealth
Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor
Pazopanib Hydrochloride in Treating Patients With Advanced Neuroendocrine Cancer
This phase II trial studies how well pazopanib hydrochloride works in treating patients with advanced neuroendocrine cancer. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for…
- Conditions
- Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor, Metastatic Digestive System Neuroendocrine Tumor G1, Multiple Endocrine Neoplasia Type 1
- Trial name
- NCT00454363
- Testing
- Laboratory Biomarker Analysis, Pazopanib Hydrochloride, Pharmacological Study
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Duodenal Adenomas
Cold Snare Endoscopic Resection for Duodenal Adenomas
Non-ampullary sporadic duodenal adenomas (SDA) are rare lesions, incidentally discovered in up to only 5% of patients during routine endoscopy.
- Trial name
- COLD SNARE (NCT04783961)
- Testing
- Cold snare endoscopic resection
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Clinico Humanitas
Ampulla of Vater Adenoma
Prophylactic Pancreatic Duct Stent Placement After ESP of Major Papillary Tumors; Prospective, Randomized Study
Endoscopic snare papillectomy (ESP) is an efficient treatment for benign tumors of the duodenal major papilla. But post-ESP pancreatitis is the most common and serious complication.
- Trial name
- PDS (NCT01737463)
- Testing
- Endoscopic snare papillectomy
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Soonchunhyang University Hospital
Functional Pancreatic Neuroendocrine Tumor, Malignant Somatostatinoma
Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor
This phase I trial studies the side effects and best dose of veliparib when given together with capecitabine and temozolomide in treating patients with neuroendocrine tumor that has spread to other places in the body and usually…
- Conditions
- Functional Pancreatic Neuroendocrine Tumor, Malignant Somatostatinoma, Merkel Cell Carcinoma, Metastatic Adrenal Gland Pheochromocytoma
- Trial name
- NCT02831179
- Testing
- Capecitabine, Temozolomide, Veliparib
- Sponsor
- Vanderbilt-Ingram Cancer Center
Post-Procedural Complications
Biliary Plus Pancreatic Stent vs Pancreatic Stent Alone After Endoscopic Papillectomy
This is a prospective, multicenter, open-label, randomized controlled trial designed to evaluate the safety and efficacy of biliary stent placement combined with pancreatic stent placement versus pancreatic stent alone in…
- Trial name
- NCT07891715
- Testing
- Endoscopic papillectomy with pancreatic duct stent placement, Endoscopic papillectomy with pancreatic duct and biliary stent placement
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Qilu Hospital of Shandong University
Islet Cell Adenoma, Neoplasm Metastasis
Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal tract, higher than normal levels of gastric acid, and tumors of the pancreas known as non-beta islet cell tumors.
- Conditions
- Islet Cell Adenoma, Neoplasm Metastasis, Zollinger Ellison Syndrome
- Trial name
- NCT00001165
- Testing
- combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatic Ductal Adenocarcinoma, Ampullary Carcinoma
Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy
This is a monocentric, prospective, randomized controlled trial comparing the safety and efficacy of laparoscopic pancreaticoduodenectomy (LPD) versus open pancreaticoduodenectomy (OPD).
- Conditions
- Pancreatic Ductal Adenocarcinoma, Ampullary Carcinoma, Distal Cholangiocarcinoma, Duodenal Adenocarcinoma
- Trial name
- NCT07328607
- Testing
- Open Pancreaticoduodenectomy, Laparoscopic Pancreaticoduodenectomy
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Minia University
Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP)
Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)
RIPAF (Rete Italiana Poliposi Adenomatosa Familiare) is a national, multicenter observational registry designed to establish a coordinated Italian network for the management of Familial Adenomatous Polyposis (FAP) and related…
- Conditions
- Familial Adenomatous Polyposis (FAP), Attenuated Familial Adenomatous Polyposis (AFAP), MUTYH-Associated Polyposis (MAP), Non-APC/MUTYH Associated Polyposis (NAMP)
- Trial name
- RIPAF (NCT07461246)
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Islet Cell Adenoma, Zollinger Ellison Syndrome
Interferon and Octreotide to Treat Zollinger-Ellison Syndrome and Advanced Non-B Islet Cell Cancer
This study will examine the safety and effectiveness of interferon-a and octreotide for the treatment of Zollinger-Ellison syndrome (gastrinoma) and advanced non-B islet cell cancer.
- Trial name
- NCT00001228
- Testing
- Interferon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)