Clinical trials: Duodenal Cancer
Helicobacter Pylori, Gastritis
Safety and Immunogenicity of Chiron's Investigational H. Pylori Vaccine in Healthy Adults
This study was designed to investigate the safety and immunogenicity of Chiron's investigational H. pylori (HP3) vaccine
- Conditions
- Helicobacter Pylori, Gastritis, Gastric Cancer, Gastroduodenal Ulcers
- Trial name
- NCT00613665
- Testing
- helicobacter pylori vaccine
- Where
- Germany
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Pancreatic Neoplasms, Bile Duct Neoplasms
Evaluation of Isolated Roux-en-Y Reconstruction After Pancreaticoduodenectomy
The purpose of this study is to evaluate the incidence of complications with the isolated Roux-en-Y reconstruction after pancreaticoduodenectomy in pancreatic tumor and periampullary tumor patients.
- Conditions
- Pancreatic Neoplasms, Bile Duct Neoplasms, Ampullary Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00915863
- Testing
- Billroth-II-type reconstruction, Isolated Roux-en-Y type reconstruction
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Wakayama Medical University
B-cell Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukemia
Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic Malignancies
The purpose of this study is to determine the safety and tolerability of intravenous (IV) and subcutaneous (SC) administration of XmAb13676 and to determine the maximally tolerated dose (MTD) and/or recommended dose (RD).
- Trial name
- NCT02924402
- Testing
- XmAb13676
- Where
- 23 sites in United States, France and 2 more
- Volunteers
- 154 people
- Sponsor
- Xencor, Inc.
Duodenal Adenoma, Duodenal Carcinoma
Analysis of Long-term Outcomes of Endoscopic Resection of Duodenal and Ampullary Mucosal and Submucosal Lesions
Mucosal and submucosal lesions of the duodenum represent a diverse group of pathologies, ranging from benign adenomas to lesions with significant malignant potential.
- Conditions
- Duodenal Adenoma, Duodenal Carcinoma, Papillary Adenoma, Papillary Adenocarcinoma
- Trial name
- DuoP-ER (NCT07781137)
- Where
- Australia
- Volunteers
- 1,000 people
- Sponsor
- Western Sydney Local Health District
Pancreatic Cancer, Cancer of the Duodenum
Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy
Pancreatoduodenectomy carries high morbidity rates even in high-volume centers. Postoperative complications often preclude or delay adequate oral nutrition and nutritional support may be required.
- Conditions
- Pancreatic Cancer, Cancer of the Duodenum, Cholangiocarcinoma, Chronic Pancreatitis
- Trial name
- NCT01642875
- Testing
- Enteral nutrition, Oral nutrition
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Pancreatic Cancer Non-resectable, Bile Duct Cancer
Treatment of Distal Malignant Biliary Obstruction by Uncovered, Partially Covered, or Fully Covered Metal Stents
The goal of this randomized controlled trial is to compare uncovered, partially covered, and fully covered self-expandable metal stents (SEMS) in the palliative treatment of distal malignant biliary obstruction in a Swedish…
- Conditions
- Pancreatic Cancer Non-resectable, Bile Duct Cancer, Papillary Carcinoma, Duodenal Cancer
- Trial name
- NCT06453590
- Testing
- Randomization to uncovered SEMS treating jaundice due to distal malignant biliary obstruction., Randomization to partially covered SEMS treating jaundice due to distal malignant biliary obstruction., Randomization to fully covered SEMS treating jaundice due to distal malignant biliary obstruction.
- Where
- 12 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Region Stockholm
Complication of Diagnostic Procedure, Adverse Effect of Diagnostic Agents, Subsequent Encounter
Dual Focus NBI and pCLE in FAP Related Duodenal Adenoma
Background: Familial adenomatous polyposis (FAP) patients are at risk to develop periampullary and non-ampullary adenoma. Either a routine biopsy or an endoscopic removal of the lesion is generally required to identify the…
- Trial name
- PIVI (NCT02162173)
- Testing
- Endoscopy
- Where
- Thailand
- Volunteers
- 26 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Pancreatic Cancer, Pancreatic Neoplasms
Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy
A pancreaticoduodenectomy is performed in patient with pancreatic cancer. The most common and serious complication is leakage between the intestine and the remnant pancreas after this procedure. It occurs in 20-30%.
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Biliary Tract Cancer, Duodenal Cancer
- Trial name
- MINIMUM (NCT03631173)
- Testing
- Surgical og radiological intervention, antibiotics
- Where
- Norway
- Volunteers
- 201 people
- Sponsor
- Oslo University Hospital
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Fistula, Pancreatic Neoplasms
Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy
The study evaluates the safety and efficacy of Neoprene-based glue in the management of pancreatic stump after pancreatoduodenectomy (PD) in patients at high risk for pancreatic fistula and early neoplastic recurrence, compared…
- Conditions
- Pancreatic Fistula, Pancreatic Neoplasms, Postoperative Complications
- Trial name
- NCT03738787
- Testing
- Pancreatic duct occlusion with Neoprene, Pancreato-Jejunal anastomosis
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Diseases of Oesophagus Stomach and Duodenum
Study of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) in Patients With Gastric Adenocarcinoma and Carcinomatosis or Positive Cytology
The goal of this clinical research study is to find the highest tolerable dose of paclitaxel that can be given as hyperthermic intraperitoneal chemotherapy (HIPEC) to patients with gastric or gastroesophageal cancer.
- Trial name
- NCT03330028
- Testing
- Dexamethasone, Diphenhydramine, Famotidine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma
Testing Obeticholic Acid for Familial Adenomatous Polyposis
This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP).
- Conditions
- Attenuated Familial Adenomatous Polyposis, Colorectal Carcinoma, Duodenal Carcinoma, Familial Adenomatous Polyposis
- Trial name
- NCT05223036
- Testing
- Biopsy Procedure, Biospecimen Collection, Gastrointestinal Endoscopy
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Helicobacter Pylori Infection, Gastric Ulcer
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer.
- Conditions
- Helicobacter Pylori Infection, Gastric Ulcer, Duodenal Ulcer, Stomach Cancer
- Trial name
- NCT03057171
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Dyspepsia, Peptic Ulcer Disease
Minimally Invasive Evaluation of Dyspepsia by Combined Magnetically Controlled Capsule Endoscopy and Urea Breath Test: a Pilot Prospective Cohort Study
The combined diagnostic accuracy of MCCE and UBT in Hong Kong patients with uninvestigated dyspepsia between age 35 to 60 years for structural pathology and HP infection is comparable to that of conventional UGI endoscopy with…
- Conditions
- Dyspepsia, Peptic Ulcer Disease, Gastroesophageal Reflux, Ugi Malignancies
- Trial name
- MCUDYSPEPSIA (NCT04918472)
- Testing
- MCCE
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Gastric Ulcer, Duodenal Ulcer
Cytokine Gene Polymorphisms in Gastric Diseases
Recently, cytokine polymorphisms are considered to play an important role in the pathogenesis of peptic ulcer and gastric cancer.
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Gastric Cancer
- Trial name
- NCT00197470
- Testing
- IL-1, TNF-alpha, Il-10
- Where
- Japan
- Sponsor
- Hamamatsu University
Gastric Cancer, Gastric Ulcer
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients
Obesity is associated with adverse airway events including desaturation during deep sedation. Previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of…
- Conditions
- Gastric Cancer, Gastric Ulcer, Intestinal Cancer, Intestinal Polyps
- Trial name
- NCT05526339
- Testing
- High-flow nasal oxygenation combined with nasopharyngeal airway, Regular nasal cannula combined with nasopharyngeal airway
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
Pancreatic Cancer, Bile Duct Cancer
Proximal Roux-en-y Gastrojejunal Anastomosis on Delayed Gastric Emptying After Pylorus-resecting Pancreaticoduodenectomy
This study aims to evaluate whether the incidence of delayed gastric emptying (DGE) can be reduced by proximal Roux-en-y gastrojejunal anastomosis in comparison with the standard gastrojejunal anastomosis in pylorus-resecting…
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Duodenal Cancer
- Trial name
- NCT02954302
- Testing
- PrPD with proximal Roux-en-y gastrojejunal anastomosis, conventional PrPD
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Cancer of Pancreas, Cancer of Duodenum
Enteral Nutrition After Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the treatment of choice for resectable periampullary cancer. PD is still associated with a relatively a high incidence of delayed gastric emptying.
- Conditions
- Cancer of Pancreas, Cancer of Duodenum, Ampulla of Vater Cancer, Cholangiocarcinoma
- Trial name
- NCT03150615
- Testing
- Early enteral nutrition, Saline, nasojejunal tube insertion
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
Healthy
A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Participants.
The purpose of this study is to assess the potential effect and safety of multiple oral doses of dexlansoprazole, lansoprazole, omeprazole or esomeprazole, once daily (QD), on the steady-state pharmacokinetics and…
- Trial name
- NCT00942175
- Testing
- Clopidogrel, Clopidogrel and Lansoprazole, Clopidogrel and Dexlansoprazole
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Takeda
Gastric Lesion, Gastritis
Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios
The goal of this clinical trial is to evaluate the diagnostic accuracy of the AI-integrated Capsule Gastroscopy (ACG) system in simulated home-use conditions for detecting upper gastrointestinal (UGI) abnormalities.
- Conditions
- Gastric Lesion, Gastritis, Upper Gastrointestinal Bleeding (UGIB), Gastric Dysplasia
- Trial name
- NCT06848400
- Testing
- AI-integrated Capsule Gastroscopy (ACG) examination, Electronic gastroduodenoscopy (EGD) examination
- Where
- 12 sites in China, Hong Kong and 1 more
- Volunteers
- 482 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University