Clinical trials: Duodenal Neoplasms
Achlorhydria, Gastrinoma
Evaluating Patients With Abnormal Levels of Gastric Acid
This study is used by the Digestive Diseases Branch to evaluate patients with suspected abnormalities in the secretion of gastric acid.
- Conditions
- Achlorhydria, Gastrinoma, Zollinger Ellison Syndrome
- Trial name
- NCT00001240
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Helicobacter Infection
Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection
Helicobacter pylori is a bacteria that infects the lining of the stomach and is associated with ulcers. Helicobacter pylori may also increase the long-term risk of developing certain forms of gastric cancer.
- Trial name
- 960025 (NCT00656968)
- Testing
- 10-day sequential treatment, 10-day concomitant therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 232 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Other Specified Disorders of Esophagus, Stomach or Duodenum
EUS-FNA Versus KHB in Diagnostics of Upper Gastrointestinal Submucosal Tumors
Upper Gastrointestinal Submucosal Tumors are tumors arising from subepithelial layers of esophageal, gastric or duodenal wall. They usually have an intact mucosa lining on the inner surface.
- Trial name
- NCT02025244
- Testing
- Key Hole Biopsy ( KHB), EUS-FNA
- Where
- 2 sites in Czechia
- Volunteers
- 52 people
- Sponsor
- Vitkovice Hospital
Pancreas Head Cancer, Pancreas Adenocarcinoma
Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)
The PANENCA trial aims to reduce postoperative complications in patients undergoing pancreatoduodenectomy (also known as a Whipple procedure), a complex surgical operation performed to remove tumors located in or near the head of…
- Conditions
- Pancreas Head Cancer, Pancreas Adenocarcinoma, IPMN, Pancreatic, Cholangio Carcinoma
- Trial name
- PANENCA (NCT07262957)
- Testing
- HOP bundle
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Gastrointestinal Carcinoma, Pancreatic Cancer
A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies
Background: Gastrointestinal (GI) cancer affects the organs (such as the stomach, large and small intestine, pancreas, colon, liver, and biliary system) of the digestive tract.
- Conditions
- Gastrointestinal Carcinoma, Pancreatic Cancer, Hepatocellular Cancer, Cholangiocarcinoma
- Trial name
- NCT06690281
- Testing
- KRAS TCR-Transduced PBL, Aldesleukin, Fludarabine
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Zollinger Ellison Syndrome
Treatment of Zollinger-Ellison Syndrome
In patients with Zollinger-Ellison Syndrome the level of gastric acid is elevated. This increased level of gastric acid is what causes the symptoms of the disease.
- Trial name
- NCT00001241
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatic Neoplasms, Bile Duct Neoplasms
Evaluation of Isolated Roux-en-Y Reconstruction After Pancreaticoduodenectomy
The purpose of this study is to evaluate the incidence of complications with the isolated Roux-en-Y reconstruction after pancreaticoduodenectomy in pancreatic tumor and periampullary tumor patients.
- Conditions
- Pancreatic Neoplasms, Bile Duct Neoplasms, Ampullary Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00915863
- Testing
- Billroth-II-type reconstruction, Isolated Roux-en-Y type reconstruction
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Wakayama Medical University
Cholecystitis, Perforated Duodenal Ulcer
Incentive Spirometry and Upper Abdominal Laparoscopic Surgery
To compare the effects of volume-oriented versus flow-oriented incentive spirometry on pulmonary function tests and functional capacity in patients of upper abdominal laparoscopic surgery.
- Conditions
- Cholecystitis, Perforated Duodenal Ulcer, Diaphragmatic Hernia, Benign Pancreas Tumor
- Trial name
- NCT04716166
- Testing
- Volume-oriented incentive spirometry, Flow-oriented incentive spirometry
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Helicobacter Pylori Infection, Peptic Ulcer
Helicobacter Pylori Antibiotic Susceptibility Testing of Korea
The purpose of this study is to make nationwide registry for antimicrobial resistance of Helicobacter pylori using single method with agar dilution in Korea.
- Conditions
- Helicobacter Pylori Infection, Peptic Ulcer, Lymphoma, Gastric Cancer
- Trial name
- NCT02961296
- Testing
- No intervention
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Asan Medical Center
Stomach Diseases
Diagnosis of Gastric Lesions From Exhaled Breath and Saliva
The investigators study the feasibility of a novel method in oncology based on breath analysis with a nanosensors array for identifying gastric diseases.
- Trial name
- NCT01420588
- Where
- 2 sites in China, Latvia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Gastric Cancer, Reflux Esophagitis
Preliminary Efficacy Analysis of "C" Single Flap Plasty Reconstruction After Laparoscopic Proximal Gastrectomy
The incidence of proximal gastric cancer has increased significantly in recent years. This may be due to weight gain, alcohol consumption, gastroesophageal reflux disease (GERD), and precancerous lesions.
- Trial name
- NCT06741501
- Testing
- "C" Single Flap Plasty Reconstruction, Normal Reconstruction
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Daorong Wang
Esophageal Neoplasms, Stomach Neoplasms
The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery
Improvements to treatment strategies for patients with cancers of the upper gastrointestinal tract have produced a large population of people who remain free from cancer recurrence in the long term following treatment.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02381249
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor
Cixutumumab, Everolimus, and Octreotide Acetate in Treating Patients With Advanced Low to Intermediate Grade Neuroendocrine Carcinoma
This phase I trial studies the side effects and best dose of cixutumumab when given together with everolimus and octreotide acetate in treating patients with advanced low- or intermediate-grade neuroendocrine cancer.
- Conditions
- Gastrin-Producing Neuroendocrine Tumor, Lung Carcinoid Tumor, Metastatic Digestive System Neuroendocrine Tumor G1, Pancreatic Glucagonoma
- Trial name
- NCT01204476
- Testing
- Cixutumumab, Everolimus, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Nutritional Support, Hepato-Biliary Neoplasm
Nutritional Support for Patients Operated for Malignant Tumors in HPD Zone
A comprehensive comparative analysis of the effectiveness of isolated enteral, isolated parenteral and mixed type of nutritional support in the early postoperative period in patients after operations performed on the malignant…
- Conditions
- Nutritional Support, Hepato-Biliary Neoplasm, Postoperative
- Trial name
- NCT06397430
- Testing
- parenteral nutrition supplements, enteral nutrition supplements, mixed nutrition supplements
- Where
- Kazakhstan
- Volunteers
- 91 people
- Sponsor
- Karaganda Medical University
Mature B-Cell Neoplasm, Non Hodgkin Lymphoma
Study of SGR-1505 in Mature B-Cell Neoplasms
The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.
- Conditions
- Mature B-Cell Neoplasm, Non Hodgkin Lymphoma, DLBCL, Waldenstrom Macroglobulinemia
- Trial name
- NCT05544019
- Testing
- SGR-1505
- Where
- 36 sites in United States, France and 6 more
- Volunteers
- 98 people
- Sponsor
- Schrödinger, Inc.
Gastric Cancer, Reflux Esophagitis
Preliminary Efficacy Analysis of 'λ+α' Double-Tract Reconstruction After Laparoscopic Proximal Gastrectomy
The incidence of proximal gastric cancer has increased significantly in recent years. This may be due to weight gain, alcohol consumption, gastroesophageal reflux disease (GERD), and precancerous lesions.
- Trial name
- NCT06475170
- Testing
- proximal gastrectomy combined with 'λ+α' double-tract anastomosis
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Northern Jiangsu People's Hospital
Duodenal Cancer
Long-term Outcomes After Resection of Primary Duodenal Adenocarcinoma
The aim of this study is to examine the long-term outcomes after curatively intended resection of duodenal adenocarcinoma.
- Trial name
- NCT05134961
- Testing
- Pancreaduodenectomy and possible adjuvant therapy
- Where
- Denmark
- Volunteers
- 113 people
- Sponsor
- Bispebjerg Hospital
Zollinger-Ellison Syndrome
Esomeprazole In Patients With Gastric Acid Hypersecretory States Including Idiopathic Hypersecretion and Zollinger-Ellison Syndrome
This research study will determine if esomeprazole, when administered twice daily at 40, 80, or 120 mg doses, can control excessive stomach acid secretion.
- Trial name
- NCT00079833
- Testing
- Esomeprazole magnesium (Nexium)
- Where
- 8 sites in United States, France
- Volunteers
- 25 people
- Sponsor
- AstraZeneca
Pancreatic Cystic Neoplasms
Inverted-Ω Anastomosis in Laparoscopic Duodenum-Preserving Pancreatic Head Resection or Laparoscopic Central Pancreatectomy
The goal of this clinical trial is to learn if inverted-Ω anastomosis after pancreatic head resection or mid-pancreatectomy works in benign or low-grade malignant tumor.
- Trial name
- NCT07087392
- Testing
- Inverted-Ω Anastomosis
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital