Clinical trials: Dupuytren Contracture
Dupuytren Contracture, Collagen Shrinkage
Registry of Patient With M. Dupuytren and Validation of the Brief MHQ
The purpose of this study is the validation of the Brief Michigan Hand Questionnaire by patient with Morbus Dupuytren and to build up a register.
- Conditions
- Dupuytren Contracture, Collagen Shrinkage, CRF
- Trial name
- NCT01876498
- Testing
- Xiaflex surgery
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Schulthess Klinik
Dupuytrens Contracture
Prospective Randomized Trial Between Needle Fasciotomy and Xiapex for Dupuytrens Contracture
The purpose of this study is to investigate whether percutaneous needle fasciotomy is as effective for treating Dupuytrens contracture as Xiapex.
- Trial name
- PNFvsxiapex (NCT02476461)
- Testing
- xiapex, percutaneous needle fasciotomy
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Dupuytren's Disease
Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859
The purpose of study AUX-CC-860 is to assess the durability of response of the AA4500 treatment regimen. This study will also evaluate long-term safety and progression of disease in joints.
- Trial name
- NCT00954746
- Where
- 39 sites in United States, Australia and 4 more
- Volunteers
- 645 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Contracture
CORRECT: COmmunity RegistRy Study Evaluating Dupuytren's Contracture Treatment
This observational study will prospectively collect data on treatment options, patient/investigator satisfaction, requirement for retreatment or additional treatment, and long-term outcomes of 3 treatment modalities(XIAFLEX…
- Trial name
- CORRECT (NCT01715467)
- Where
- 27 sites in United States
- Volunteers
- 162 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Contracture
Efficacy and Safety of Xiaflex Injection for Treatment of Dupuytren's Contracture of the Thumb
This study will evaluate the efficacy and safety of clostridial collagenase injections for treatment of Dupuytren's contracture of the thumb and first web space.
- Trial name
- NCT01265420
- Testing
- Injectable clostridial collagenase
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Dupuytren's Disease
Validation of Two New Questionnaires for Dupuytren's Disease
A study to validate two newly developed questionnaires for Dupuytren's Disease. The objective is to develop a patient specific outcomes tool for Dupuytren's Disease.
- Trial name
- NCT01446432
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Robert Hotchkiss
Dupuytren's Contracture
Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
OBJECTIVES: Evaluate the safety and efficacy of collagenase in improving flexion deformity, range of motion, and grip strength in patients with residual Dupuytren's disease.
- Trial name
- NCT00004409
- Testing
- collagenase
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- State University of New York
Dupuytren's Contracture
Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease
OBJECTIVES: I. Compare the safety and efficacy of clostridial collagenase vs placebo in terms of improving the degree of flexion deformity, range of finger motion, and grip strength in patients with residual stage Dupuytren's…
- Trial name
- NCT00014742
- Testing
- collagenase
- Volunteers
- 72 people
- Sponsor
- State University of New York
Knee Replacement Arthroplasty, Fibrosis
Knee Stiffness in Fibrosis Diathesis
At the standard follow-up moment one year after primary TKA for gonarthrosis, all patients will be checked for signs of fibrosis diathesis.
- Conditions
- Knee Replacement Arthroplasty, Fibrosis, Dupuytren's Disease
- Trial name
- NCT02294890
- Testing
- Total knee arthroplasty
- Volunteers
- 60 people
- Sponsor
- University Hospital Pellenberg
Dupuytren's Disease
Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture
The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between injection and manipulation.
- Trial name
- NCT01226121
- Testing
- Clostridial collagenase injectable
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Indiana Hand to Shoulder Center
Dupuytren Contracture
Collagenase and Needle Aponeurotomy: Single Modality Versus Combination Treatment for Dupuytren's Disease
Dupuytren's disease results in deformity of the hand and this can lead to trouble with daily activities. Treatment traditionally involves cutting out diseased tissue, however this can cause damage to important structures in the…
- Trial name
- NCT01776892
- Testing
- Collegenase injection, Needle aponeurotomy
- Where
- Canada
- Sponsor
- University of Alberta
Dupuytren's Contracture
Treatment Of Dupuytren's Contracture With Collagenase Clostridium Histolyticum Injection (Xiapex)
This study will evaluate the impact of Xiapex treatment on the range of motion (ROM) of the affected fingers and the patient and physician reported treatment satisfaction and disease severity and their relation to ROM.
- Trial name
- POINT X (NCT01229436)
- Testing
- Xiapex
- Where
- 28 sites in Denmark, France and 6 more
- Volunteers
- 254 people
- Sponsor
- Pfizer
Dupuytren's Contracture
Effects of Steroid Injection With Percutaneous Needle Aponeurotomy in Dupuytren's Contracture
Background: Dupuytren's contracture is a common hand problem that causes certain fingers to bend towards the palm. Patients with this condition cannot perform daily activities and many are unable to work.
- Trial name
- NCT00565019
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dupuytren's Contracture
Evaluation of the Efficiency of Autologous Platelet Gel (Platelet Rich Fibrin) Obtained From Own Patients' Blood Versus Vaselitulle in Dupuytren's Disease Postoperative Wound Healing
This study is a clinical, multicentric, randomised open trial. The objective is to evaluate the efficiency, in terms of wound healing speed, of peroperative application of autologous platelets gel versus standardized wound…
- Trial name
- NCT00931567
- Testing
- Autologous platelets gel, Vaselitulle
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Dupuytren Contracture
Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)
Dupuytren's disease is a progressive disease due to unknown causal agents or genetics. Dupuytren's disease contains nodules and cords in the fascia as the epicenter of disease progression.
- Trial name
- DupuyShock (NCT01184586)
- Testing
- Intervention - ESWT Storz Duolith high energy
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Hannover Medical School
Dupuytren's Contracture
Health-Related Quality of Life in Patients With Dupuytren's Disease
Main Research Questions: We want to measure the change in quality of life in Dupuytren's disease patients who do and do not undergo surgery.
- Trial name
- NCT00468949
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Dupuytren's Disease
Collagenase in the Treatment of Dupuytrens Disease
The purpose of the study is to determine if collagenase will reduce the degree of contracture in the primary joint in subjects with Dupuytren's disease.
- Trial name
- NCT00260429
- Testing
- collagenase clostridium histolyticum
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Stony Brook University
Dupuytren's Disease
Splinting for Dupuytren's Contracture Release
This study is comparing two different kinds of splints for patients who have had a surgical contracture release of dupuytren's disease. It compares a static splint and a dynamic splint.
- Trial name
- NCT00575458
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital