Clinical trials: Dupuytren Disease
Dupuytren Contracture, Disease Progression
Natural Disease Progress of Dupuytren Disease
Dupuytren disease (DD) is a progressive fibromatosis of the palmar fascias of the hand and fingers, which may lead to extension deficits of the fingers.
- Trial name
- DD (NCT01923103)
- Where
- Netherlands
- Volunteers
- 261 people
- Sponsor
- University Medical Center Groningen
Dupuytren Contracture, Dupuytren Disease of Palm and Finger
Treatment of Dupuytren's Disease With Minimal Invasive Surgery and VIVOSORB® Resorbable Implant Device
Dupuytren's disease is a progressive fibroproliferative condition of the hand which progresses in 20% of patients into a serious condition.
- Trial name
- Vivosorb (NCT03741764)
- Testing
- Vivosorb
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- prof. dr. Ilse Degreef
Dupuytren Disease of Palm and Finger, With Contracture
Hand Therapy or Not Following Collagenase Treatment for Dupuytren's Contracture?
This study evaluates if hand therapy have an impact on the patients' preformance of and satisfaction with everyday activities or not following collagenase injection treatment for Dupuytren's contracture.
- Trial name
- NCT03580213
- Testing
- Hand therapy MCPJ affected, Hand therapy PIPJ affected
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- Haukeland University Hospital
Dupuytren's Disease
Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's
This is a prospective, multi-centre, pragmatic randomized controlled trial to compare both the clinical effectiveness and cost-effectiveness of collagenase injections (CI) versus limited palmar fasciectomy (LPF) to determine if…
- Trial name
- EXTEND (NCT02725528)
- Testing
- collagenase injection, limited palmar fasciectomy
- Where
- 10 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dupuytren Contracture, Dupuytren's Disease
Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
Comparing percutaneous needle fasciotomy +/- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.
- Conditions
- Dupuytren Contracture, Dupuytren's Disease, Contracture, Joint Diseases
- Trial name
- NCT05440240
- Testing
- Percutaneous needle fasciotomy, Corticosteroid injection, Saline injection
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Regionshospitalet Silkeborg
Soft Tissue Injuries, Distal Radius Fracture
Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers.
Trauma and soft injuries of the wrist, hand and fingers have a high incidence, and large social and healthcare costs are generated, mainly due to productivity loss.
- Conditions
- Soft Tissue Injuries, Distal Radius Fracture, Metacarpal Fracture, Carpal Fracture
- Trial name
- NCT04669704
- Testing
- Experimental: Tablet application, Comparator: Conventional treatment
- Where
- 2 sites in Spain
- Volunteers
- 663 people
- Sponsor
- University of Seville
Hand Injuries and Disorders, Distal Radius Fracture
The Role of Tranexamic Acid in Reducing Post Operative Hand Edema After Hand and Wrist Surgery
Hand edema following hand surgery is a common yet devastating side effect that can lead to early stiffness, prolonged rehabilitation and diminished function.
- Conditions
- Hand Injuries and Disorders, Distal Radius Fracture, Dupuytren Contracture
- Trial name
- THAW (NCT04907812)
- Testing
- Tranexamic acid, Surgery
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ruby Grewal
Dupuytren Disease
Percutaneous Aponeurotomy in the Treatment of Dupuytren's Disease
The efficiency of percutaneous aponeurotomy in the treatment of Dupuytrens disease is well known. However, the duration of the clinical improvement after aponeurotomy is not well known.
- Trial name
- APADUP (NCT02474576)
- Testing
- Percutaneous aponeurotomy
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Dupuytren's Contracture of the Hand (Viking's Disease)
Liposome Bupivacaine for WRIST Blocks
Treatment of Dupuytren's contracture requires multiple injections into the palm of the hand to weaken the cords, followed by rupture of the strands 2 days later. Anesthesia is required for both phases of treatment.
- Trial name
- NCT03106519
- Testing
- Liposome bupivacaine + bupivacaine
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- Catherine Vandepitte, M.D.
Dupuytren's Disease, Surgical Incision
Tolerance and Efficacy Study of Second-line Surgery After Percutaneous Needle Aponeurotomy for Dupuytren's Disease.
As part of a graduated medical-surgical strategy, and in our practice, surgery for Dupuytren's disease appears as a second-line treatment indicated in a situation of failure after treatment with percutaneous needle…
- Trial name
- URAM3 (NCT04164953)
- Testing
- Surgical treatment
- Where
- France
- Volunteers
- 50 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Carpal Tunnel Syndrome, Dupuytren Contracture
Ibuprofen Plus Acetaminophen Versus Oxycodone Alone After Hand Surgery
This study is about pain control and medication following outpatient soft-tissue hand surgery. We hope to learn if ibuprofen and acetaminophen will achieve similar pain relief and satisfaction when compared with oxycodone alone.
- Conditions
- Carpal Tunnel Syndrome, Dupuytren Contracture, Trigger Digit, Ganglion Cysts
- Trial name
- NCT03111186
- Testing
- Oxycodone Hcl 5Mg, Ibuprofen 400 mg, Acetaminophen 650 mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Osteoarthritis, Dislocations
Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data
Surgery is a common treatment type for damaged joints, tendons and nerves in the upper limb where conservative measures are inappropriate or have failed.
- Conditions
- Osteoarthritis, Dislocations, Inflammatory Arthritis, Rotator Cuff Tear
- Trial name
- NCT03573765
- Testing
- Shoulder arthroplasty, Elbow arthroplasty, Hand and wrist arthroplasty
- Volunteers
- 8,308,821 people
- Sponsor
- University of Oxford
Advanced Dupuytren's Disease
AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease
Study AUX-CC-858 was an open-label continuation of the double-blind Study AUX-CC-857 (NCT00528606). Subjects who complete the Day 90 visit after their initial injection in Study AUX-CC-857 (NCT00528606) entered into Study…
- Trial name
- NCT00528424
- Testing
- AA4500
- Where
- 15 sites in United States
- Volunteers
- 286 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Advanced Dupuytren's Disease
Safety and Efficacy Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease
This was a Phase 3, 9-month, open-label study conducted in the United States. Subjects with a diagnosis of advanced Dupuytren's disease in a metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint that resulted in a…
- Trial name
- JOINT-I (NCT00528840)
- Testing
- collagenase clostridium histolyticum
- Where
- 14 sites in United States
- Volunteers
- 201 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Advanced Dupuytren's Disease
Non-US Study of AA4500 (XIAFLEX™, Proposed Name) in the Treatment of Advanced Dupuytren's Disease
This 12-month study had two phases: a 90-day double-blind, randomized, placebo-controlled phase and a nine-month open-label extension phase.
- Trial name
- CORD-II (NCT00533273)
- Testing
- collagenase clostridium histolyticum
- Where
- 7 sites in Australia
- Volunteers
- 66 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease
Retreatment of Recurrent Dupuytren's Contractures
The objectives of this study are to assess the safety and efficacy of AA4500 in the retreatment of recurrent contractures in joints that were effectively treated with AA4500 in a previous Auxilium-sponsored Phase 3 study.
- Trial name
- NCT01498640
- Testing
- Collagenase clostridium histolyticum
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 52 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease
Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules
The objectives of this study are to assess the safety and effectiveness of AA4500 in treating palmar Dupuytren's disease nodules.
- Trial name
- NCT02193828
- Testing
- Collagenase clostridium histolyticum
- Where
- 11 sites in United States, Australia
- Volunteers
- 76 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Dupuytren's Disease
MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
The purpose of this study is to determine the effects of XIAFLEX on your finger through MRI.
- Trial name
- NCT01450397
- Testing
- XIAFLEX
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Hospital for Special Surgery, New York
Dupuytren's Disease
Registry of Dupuytren's Contracture Treatment Outcomes
Experience with Microbial Collagenase (trade name Xiapex) in Europe currently is limited to randomised controlled studies.While such studies are essential to determine efficacy and safety of the product (usually compared to…
- Trial name
- ReDuCTO (NCT01567397)
- Where
- 4 sites in Germany
- Volunteers
- 87 people
- Sponsor
- Technische Universität Dresden
Dupuytren Contracture, Dupuytren's Disease of Finger
Collagenase Injection vs Percutaneous Needle Aponeurotomy for Dupuytren's Disease
Dupuytren's disease is a non-curative, progressive disorder leading to function-impairing deformities of the hand. Although numerous treatments exist, the most common and widely accepted therapy is removal of diseased fascia.
- Trial name
- NCT03000114
- Testing
- Percutaneous Needle Aponeurotomy, XIAFLEX
- Where
- Canada
- Volunteers
- 334 people
- Sponsor
- University of Calgary