Clinical trials: Dupuytren Disease, active
Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS)
Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test
The goal of this clinical trial is to understand how people make decisions about imaging tests for common musculoskeletal problems (like arthritis, tendon problems, or nerve compression).
- Conditions
- Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS), Lateral Epicondylitis, Osteoarthritis
- Trial name
- NCT07158892
- Testing
- Diagnostic Advance Care Planning Discussion, Informational Statement Only
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Texas at Austin
Dupuytren Disease
Skin Involvement in Dupuytren Surgical Treatment Outcome
Palmar skin is often retracted in Dupuytren disease (DD), making surgical management challenging and skin-preserving surgery difficult.
- Trial name
- Skin in DD (NCT07470684)
- Testing
- Suction cutometry, Ultrasound measurement, Microbiopsy for histological analysis
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Contracture, Dupuytren Disease of Finger
Safety and Efficacy Study of Collagenase CNT201 Injection for Treatment of Dupuytren's Contracture
This trial is a multicenter, Phase 1/2, study to assess the safety, tolerability, efficacy, PK, and immunogenicity of CNT201 in adult participants with DC (Dupuytren's Contracture).
- Trial name
- NCT07640425
- Testing
- [Step1] CNT201 First-dose, [Step1] CNT201 Low-dose, [Step1] CNT201 Intermediate-dose
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- CONNEXT
Dupuytren's Disease
Nodular Shrinking in Dupuytren Disease
Dupuytren disease (DD) is a common hand disorder with disabling finger contractures that may require surgery to restore function.
- Trial name
- Echo (NCT06321991)
- Testing
- Ultrasound measurement
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Contracture
Trial Comparing Treatment Strategies in Dupuytren's Contracture
Trial is a prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial. The research objective is to determine, which treatment strategy 1) primary percutaneous needle fasciotomy…
- Trial name
- DETECT (NCT03192020)
- Testing
- Percutaneous needle fasciotomy (PNF), Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], Limited fasciectomy (LF)
- Where
- 6 sites in Finland
- Volunteers
- 302 people
- Sponsor
- Tampere University
Dupuytren's Disease
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease
Dupuytren's disease is a frequent hereditary disease in Northern Europe. It is a degenerative disease affecting the palmar aponeurosis of the hand.
- Trial name
- REMEDY (NCT05067764)
- Testing
- Aponeurectomy with grafting, Aponeurectomy alone
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- Elsan
Dupuytren's Disease, Dupuytren Contracture
Post-contracture Release Radiation for Dupuytren's Disease
To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.
- Conditions
- Dupuytren's Disease, Dupuytren Contracture, Dupuytren Disease of Palm and Finger, Dupuytren Disease of Finger
- Trial name
- NCT04122313
- Testing
- Evaluation of Dupuytren's Disease Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Dupuytren's Disease
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
Dupuytren disease (DD) is a highly prevalent disabling hand disease. Spontaneous fibrosis nodules and strands in the palms of the hand cause finger contractures in disturbing positions and movement restrictions.
- Trial name
- Micronerves (NCT06142929)
- Testing
- Microfasciectomy
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren Disease
Ultrasound Features of Dupuytren's Disease
Dupuytren's disease (DD) is a benign and progressive condition that affects the palmar aponeurosis with a very high global incidence.
- Trial name
- Micro in DD (NCT06956027)
- Testing
- Ultrasound assesment, ROM measurement
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dupuytren's Disease
Prognostic Profile of Dupuytren's Disease: a Cohort Study (PRODUCT)
Dupuytren's disease is characterized by retractile fibrosis of the superficial palmar aponeurosis, which can lead to irreversible flexion contractures of the fingers and lasting functional impairment.
- Trial name
- PRODUCT (NCT07353060)
- Testing
- Questionnaires, Clinical examination
- Where
- France
- Volunteers
- 305 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Dupuytren&Amp;#39;s Contracture, Dupuytren&Amp;#39;s Fasciectomy
Preoperative Serial Casting, Education, and Therapy for Dupuytren's Contracture
We are running a small study to test whether a special type of therapy - including casting, stretching, and massage - might help improve recovery after Dupuytren's Fasciectomy.
- Conditions
- Dupuytren&Amp;#39;s Contracture, Dupuytren&Amp;#39;s Fasciectomy, Dupuytren&Amp;#39;s Disease
- Trial name
- PRESCET (NCT07024576)
- Testing
- Preoperative casting intervention
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Bournemouth University
Dupuytren Disease of Finger
Fasciectomy vs Collagenase Injection in Recurrent Dupuytren Disease
This randomized controlled trial will compare the outcome of surgery (fasciectomy) with that of local injection of Collagenase Clostridium Histolyticum in patients with recurrent finger joint contracture after previous treatment…
- Trial name
- NCT03406338
- Testing
- Fasciectomy, Collagenase Clostridium Histolyticum
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Dupuytren Disease of Finger
Effectiveness of Percutaneous Needle Aponeurotomy
The main objective is to investigate if percutaneous needle aponeurotomy is non-inferior to open surgery using aponeurectomy in treatment of flexion contracture due to Dupuytren's disease.
- Trial name
- EFAPAD (NCT03797690)
- Testing
- Percutaneous needle aponeurotomy, Open surgery with limited aponeurectomy
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dupuytren Contracture, Dupuytren's Disease
Effectiveness of Night Splinting After Percutaneous Needle Fasciotomy in Dupuytren's Contracture
Dupuytren's contracture (DC) is associated with progressive finger flexion and extension deficit caused by fibrosis in the palm and digits.
- Trial name
- NCT05300893
- Testing
- No night splint
- Where
- 3 sites in Sweden
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Dupuytren Contracture, Dupuytren's Disease
Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
Comparing percutaneous needle fasciotomy +/- corticosteroid injection for Dupuytren's contracture affecting metacarpophalangeal joints. A clinician-initiated, multicenter, randomized controlled trial.
- Conditions
- Dupuytren Contracture, Dupuytren's Disease, Contracture, Joint Diseases
- Trial name
- NCT05440240
- Testing
- Percutaneous needle fasciotomy, Corticosteroid injection, Saline injection
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Regionshospitalet Silkeborg