Clinical trials: Duration of Response
Metabolic Disease
Resistance Exercise, Metabolism and Time of Day
The aim of the current study is to determine the effect of time of day on the muscle and metabolic responses to resistance exercises in obese or overweight adults. To achieve this aim we have the following objectives: 1.
- Trial name
- NCT05321914
- Testing
- Exercise training
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Septic Shock
Velocity Time Integral vs PICCO for Evaluation of Passive Leg Raising in Septic Shock
The objective of the present study is to investigate accuracy of changes in cardiac output following passive leg raising as estimated by transthoracic ultrasound as method to predict fluid responsiveness and compare that to…
- Trial name
- VIPS (NCT03621449)
- Where
- 2 sites in Sweden
- Sponsor
- Region Skane
Plaque Psoriasis
Efficacy, Safety, Preference and Response Duration of Clobex® Spray and Taclonex® Ointment in Psoriasis
Evaluate the efficacy of Clobex® Spray as compared to Taclonex® Ointment in terms of Overall Disease Severity and Investigator Global Assessment.
- Trial name
- NCT00437255
- Testing
- Clobetasol Propionate, 0.05%, Calcipotriene and betamethasone dipropionate ointment
- Where
- 4 sites in United States
- Volunteers
- 122 people
- Sponsor
- Galderma R&D
HCC, Hepatocellular Carcinoma
Y-90 Treatment Response Using Transarterial Radioembolization
This prospective clinical study will examine the ability of contrast-enhanced ultrasound (CEUS) to assess the treatment response of hepatocellular carcinoma (HCC) to transarterial radioembolization (TARE).
- Conditions
- HCC, Hepatocellular Carcinoma, Liver Cancer, Hepatic Neoplasm
- Trial name
- TARE (NCT07145801)
- Testing
- Lumason, Sonazoid
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University
Depression, Major Depressive Disorder
Effect of SSRIs on Response to Psilocybin Therapy
This study is an open-label, single-arm, within-subjects design in individuals with mild-moderate Major Depressive Disorder (MDD). All participants will receive a single dose of 25mg of psilocybin in a therapeutic setting.
- Conditions
- Depression, Major Depressive Disorder, Mild Depression, Moderate Depression
- Trial name
- NCT05594667
- Testing
- Psilocybin
- Where
- Canada
- Sponsor
- Cybin Therapeutics Inc.
Chronic Hepatitis C, Genotype
A Randomized Trial of 24-Week Versus 48-Week Courses of Peginterferon Plus Ribavirin for HCV Genotype-1 Patients
The purposes of this study are: 1. To evaluate whether treatment with peginterferon and ribavirin for 24 weeks is sufficient to achieve a sustained virological response (SVR) rate comparable to that observed with the standard…
- Trial name
- NCT00629967
- Testing
- pegylated interferon alpha 2a and ribavirin, Pegylated interferon alfa-2a and ribavirin
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Histological Response of Tissue to Cold
Probe Configuration and Time-Temperature Dose Ranging for Understanding of Skin Lesion Effects
This study is designed to characterize the biological response of the epidermis, dermis and subcutaneous tissue to treatment with the Myoscience Cryo-Touch III system.
- Trial name
- NCT01681745
- Testing
- Cryo-Touch III
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Hallux Valgus
The Effect of Foot Orthoses on the Braking Response Time
Patients often seek advice from their treating doctor if they are able to drive with a foot orthosis after a first metatarsal osteotomy for symptomatic hallux valgus and/or after an additional forefoot surgery.
- Trial name
- NCT02354066
- Testing
- Hallux valgus Shoe, Forefoot relief shoe, Retail Shoe
- Where
- Austria
- Volunteers
- 42 people
- Sponsor
- Medical University Innsbruck
no Conditions
Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses
Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.
- Trial name
- NCT05067062
- Testing
- New Zealand blackcurrant extract
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Chichester
Hepatitis C, Chronic
Individually Adapted Therapy Duration for the Treatment of Chronic Hepatitis C Genotype 1 Infection
Patients with chronic hepatitis C genotype 1 virus infection are usually treated with Interferon alfa plus Ribavirin over 48 weeks. For some patients this might be too long, for others too short.
- Trial name
- NCT00351403
- Testing
- Ribavirin, Peginterferon alfa 2b
- Where
- 22 sites in Germany
- Volunteers
- 390 people
- Sponsor
- FGK Clinical Research GmbH
Relapsed/Refractory Mantle Cell Lymphoma
A Trial of Ibrutinib, Lenalidomide and Rituximab for Patients With Relapsed/Refractory Mantle Cell Lymphoma
In this trial, patients with mantle cell lymphoma will be included, treatment with lenalidomide, rituximab and ibrutinib will be administered in an induction phase for up to 12 cycles, cycle length 28 days.
- Trial name
- PHILEMON (NCT02460276)
- Testing
- Lenalidomide, Ibrutinib, Rituximab
- Where
- 5 sites in Denmark, Finland and 2 more
- Volunteers
- 50 people
- Sponsor
- Lund University Hospital
Bone Marrow Transplantation
An Adaptive Phase I Study to Evaluate the Safety, Efficacy and Dose Responses of Ronacaleret in Healthy Human Volunteers
Ronacaleret is an orally administered CaSR antagonist which has previously been demonstrated to transiently increase PTH in both animals and humans.
- Trial name
- NCT01466335
- Testing
- Ronacaleret (100mg tablet)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Heat Acclimation and Thermotolerance, Heat Effect
Exercise in Extreme Hot Weather Conditions
Background: Core body temperature increases in hot climates due to exercise workload, disrupting heat gain and loss of balance. The human thermoregulatory system regulates core body temperature through factors such as metabolic…
- Trial name
- EXHOTCON (NCT07307391)
- Testing
- hot wet high (HWH), hot dry high (HDH), Experimental: hot dry low (HWL)
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Valladolid
Acute Lung Injury, Acute Respiratory Distress Syndrome
Timing and Intensity of the Exposures and Attributable Burden of Acute Lung Injury
The purpose of the study is to identify the patients at high risk of developing Acute Lung Injury (ALI) at the time of hospital admission, and before intensive care unit admission.
- Trial name
- LIPS (NCT00980915)
- Where
- United States
- Volunteers
- 6,600 people
- Sponsor
- Mayo Clinic
Functional Constipation
Multistrain Probiotic for Functional Constipation
Subjects will be screened and will enter a placebo-only 2-week run-in period during which constipation symptoms will be evaluated and any disallowed products (e.g. probiotics) must be discontinued.
- Trial name
- NCT01618617
- Testing
- High dose Multistrain probiotic, 100 billion cfu/day, Low dose Multistrain probiotic, 15 billion cfu/day
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Renew Life Formulas Inc
Stress Disorders, Post-Traumatic
Real-time fMRI and Neurofeedback of Brain Networks Mediating Trauma Memory Recall in PTSD
The purpose of the current study is to develop a better understanding of the brain mechanisms involved in psychological treatments for posttraumatic stress disorder (PTSD).
- Trial name
- NCT02500719
- Testing
- Computational Model - Real-time Support Vector Machine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8
Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients With Non-Small Cell Lung Cancer
This phase III trial compares the effect of adding AZD6738 to durvalumab versus durvalumab alone to increase time without cancer in patients with non-small cell lung cancer, following treatment with chemotherapy and surgery.
- Conditions
- Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
- Trial name
- NCT06732401
- Testing
- Biospecimen Collection, Ceralasertib, Computed Tomography
- Where
- 192 sites in United States
- Volunteers
- 630 people
- Sponsor
- National Cancer Institute (NCI)
Septic Shock, Resuscitation
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock
The aim of this study is to compare the effect of resuscitation guided by Left ventricular outflow tract-velocity time integral (LVOT-VTI) variation versus the effect of resuscitation guided by inferior vena cava (IVC) variation…
- Trial name
- NCT06122909
- Testing
- Group VTI, Group IVC
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Kasr El Aini Hospital
Colorectal Carcinoma
Axitinib as Maintenance Treatment in Patients With Metastatic CRC
The purpose of this study is to evaluate the maintenance therapy with axitinib in patients with metastatic colorectal carcinoma
- Trial name
- TTD-11-01 (NCT01483638)
- Testing
- axitinib
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
High Blood Pressure
Immediate Pressor Response to Oral Salt
The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
- Trial name
- IPROS (NCT06226636)
- Testing
- salt
- Where
- 2 sites in Zambia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mulungushi University