Clinical trials: Duration of Response
Glaucoma
Effect of Age on Latanoprost 0.005% in Patients With Glaucoma
Latanoprost is a commonly used treatment for glaucoma. Because of its mechanism of action, it is plausible that the age of a patient using the medication may affect its efficacy and time of onset.
- Trial name
- NCT00224289
- Testing
- Latanoprost 0.005%
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Yale University
Alcohol Abuse, Craving
Using Neurofeedback to Understand the Relationship Between Stress and Alcohol Consumption
In this research project, the aim is to discover the role specific brain networks play in the relationship between stress reactions and the desire for alcohol and alcohol consumption.
- Conditions
- Alcohol Abuse, Craving, Psychosocial Stressor, Neural Stress Response
- Trial name
- NeuStress (NCT06247306)
- Testing
- ScanSTRESS fMRI-paradigm (Streit et al., 2014), real-time fMRI neurofeedback
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Mental Fatigue, Athletic Performance
Effects of Mental Fatigue Duration on Cortical Activity and Jump Performance
"This study investigates whether the length of time spent on a mentally demanding task affects brain activity and jumping performance in physically active young men.
- Conditions
- Mental Fatigue, Athletic Performance, Cognitive-Motor Interaction
- Trial name
- MF-CMJ-EEG (NCT07754604)
- Testing
- Nature Documentary (Control), 10-Minute Stroop Task, 15-Minute Stroop Task
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Inonu University
CMV Colitis
Stool and Serum CMV-PCR in Diagnosing CMV Colitis
CMV viral load detected by real-time polymerase chain reaction (PCR) in either serum or stool may be beneficial in diagnosing CMV colitis, but the data is limited.
- Trial name
- NCT05522283
- Testing
- Stool and blood CMV PCR
- Where
- Thailand
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Plaque Psoriasis
Efficacy/Safety/Subject Satisfaction/Duration of Response of Clobetasol Propionate Spray vs Ointment in Plaque Psoriasis
This study is a comparison between Clobetasol Propionate Spray and Clobetasol Propionate Ointment with Regard to Efficacy, Safety, Subject Satisfaction and Duration of Response in Moderate to Severe Stable Plaque Psoriasis.
- Trial name
- NCT00733954
- Testing
- clobetasol propionate spray, clobetasol propionate ointment
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Galderma R&D
Septic Shock, Sepsis
Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM)
Sepsis is a common syndrome resulting from a dysregulated response to infection. The timing of antibiotic initiation is an important determinant of outcomes for patients presenting to the emergency department with sepsis.
- Trial name
- NCT03226366
- Testing
- Immediate evaluation by multidisciplinary team
- Where
- 4 sites in United States
- Volunteers
- 3,230 people
- Sponsor
- Intermountain Health Care, Inc.
Respiratory Distress, Acute Lung Injury
Lung Injury Prediction Study
The purpose of the study is to externally validate the acute lung injury/acute respiratory distress syndrome (ALI/ARDS) prediction model (Lung Injury Prediction Score - LIPS) in a multicenter sample of patients at risk presented…
- Trial name
- USCTG-LIPS1 (NCT00889772)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Hypersensitivity
The Duration of the Suppressive Effects of Desloratadine on Allergen Prick Tests After Discontinuation (P04441)
This is a randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single center study in subjects with positive histamine skin prick test and a positive RadioAllergoSorbent Test (RAST) (class > 2) to one of…
- Trial name
- NCT00359138
- Testing
- desloratadine, levocetirizine
- Volunteers
- 36 people
- Sponsor
- Organon and Co
Consumer Behavior, Consumer Preference
Impact of Chip Thickness and Size on Eating Responses
To analyze prototypes developed with the base and seasonings of products that exhibit variations in chip thickness and size. The information obtained from this analysis will serve as the basis for subsequent research to explore…
- Conditions
- Consumer Behavior, Consumer Preference, Consumer Satisfaction
- Trial name
- NCT06691958
- Testing
- Tortilla corn chips 4-5 pieces, eat one piece at time, Tortilla corn chips 90 grams, Extruded corn chips 90 grams
- Where
- United Kingdom
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Sepsis, Septic Shock
Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics
Sepsis is triggered by an infection and represents one of the greatest challenges of modern intensive care medicine. With regard to a targeted antimicrobial treatment strategy, the earliest possible pathogen detection is of…
- Trial name
- DigiSep (NCT04571801)
- Testing
- Standard diagnostics, Next Generation Sequencing (NGS)
- Where
- 22 sites in Germany
- Volunteers
- 410 people
- Sponsor
- University Hospital, Essen
Iron Deficiency Anemia
Effects of Oral Iron Supplementation on Vaccine Response in Iron Deficient Kenyan Women
Iron deficiency (ID) anemia (IDA) is a global public health problem, with the highest prevalence in Africa. Vaccines often underperform in low- and middle- income countries (LMIC), and undernutrition, including ID, likely plays a…
- Trial name
- NCT05919472
- Testing
- Oral iron supplementation (pre-treatment), COVID-19 vaccine, MenACWY vaccine
- Where
- Kenya
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nicole Stoffel
Complete Remission Rate， CRR, Progression Free Survival
Sintilimab, Chidamide, and Azacitidine for Untreated Stage I-II Extranodal NK/T-Cell Lymphoma
This is an open-label, single-arm, multi-center Phase II clinical trial evaluating the efficacy and safety of a novel sequential regimen as first-line therapy for treatment-naïve patients with Extranodal NK/T-cell Lymphoma…
- Conditions
- Complete Remission Rate， CRR, Progression Free Survival, Overall Survival, Adverse Event
- Trial name
- SCENT-3 (NCT07542912)
- Testing
- SCA Induction followed by Response-Adapted Therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Pneumonia, Sepsis
Therapeutic Drug Monitoring - Targeting IMproved Effectiveness
Severe infections can be caused by various organisms, such as bacteria or viruses, and lead to otherwise healthy people getting very unwell, sometimes needing treatment in hospital or even intensive care.
- Conditions
- Pneumonia, Sepsis, Infection, Bacterial
- Trial name
- TDM-TIME (NCT05971979)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester University NHS Foundation Trust
Sepsis
The Influences of Early Mobilization on Myokines, Body Composition and Outcomes in ICU Septic Patients
the investigators' preliminary data revealed that early physical therapy in patients with sepsis in ICU could promote recovery of function (liver and kidney) and decrease the length of stay in hospitalization.
- Trial name
- NCT06061224
- Testing
- early mobilization (physical therapy)
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Chang Gung Memorial Hospital
Spinal Cord Injuries, Incomplete Spinal Cord Injury
A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES
Neuromuscular electrical stimulation (NMES) remains as one of the effective rehabilitation modalities for addressing recovery of neuromuscular function after a spinal cord injury (SCI).
- Trial name
- NCT05243576
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Sarcoma
Efficacy of the Combination of Nivolumab and Ipilimumab as a Treatment in Patients With Sarcoma of Rare Subtype
This is a randomized open label study, with 2 arms treatments conducted in patients with metastatic or unresectable advanced sarcoma of rare subtype; previously treated by anthracycline-based regimen except for whom standard…
- Trial name
- RAR-Immune (NCT04741438)
- Testing
- Nivolumab and IPILIMUMAB, Pazopanib Oral Tablet [Votrient]
- Where
- 13 sites in France
- Volunteers
- 96 people
- Sponsor
- Centre Leon Berard
Mpox (Monkeypox)
Assessment of Immune Memory - Humoral and Cellular - in mPOX-infected Patients : an Ancillary Study of the ANRS0258s MOSAIC Cohort
Primary objective The overall objective is to assess the long-term amplitude and durability of the immune responses after mpox virus (MPXV) infection.
- Trial name
- POXAIM (NCT07592429)
- Testing
- blood sampling
- Volunteers
- 60 people
- Sponsor
- ANRS, Emerging Infectious Diseases
The Duration of Motor Block May Vary Between 12-36 Hrs
The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block
The duration of motor block for infragluteal parabiceps sciatic nerve block following total knee replacement may vary between 12-36 hrs depending on the amount of local anesthetic given.
- Trial name
- NCT01272921
- Testing
- Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northwestern University
Necrotizing Soft Tissue Infection, Fournier Gangrene
Necrotizing Soft Tissue Infections
SnapNSTI is an international, multicenter, time-bound prospective observational cohort study designed to characterize current epidemiology, management patterns, and outcomes of patients with necrotizing soft-tissue infections…
- Conditions
- Necrotizing Soft Tissue Infection, Fournier Gangrene, Sepsis, Surgical Infection
- Trial name
- SnapNSTI (NCT07107555)
- Where
- Spain
- Volunteers
- 480 people
- Sponsor
- European Society for Trauma and Emergency Surgery
Psoriatic Arthritis
Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)
This study was designed to leverage the sensitivity of ultrasonography available in clinical practice setting to better describe the time course of response to secukinumab (150 mg and 300 mg) on joint synovitis and enthesitis in…
- Trial name
- PDUS (NCT02662985)
- Testing
- AIN457 (secukinumab)
- Where
- 33 sites in United States, Argentina and 15 more
- Volunteers
- 166 people
- Sponsor
- Novartis Pharmaceuticals