Clinical trials: Dydrogesterone
Infertility
Predictors of Pregnancy Rate in Assisted Reproductive Technology According to Actual Guidelines
Goals: To explore the association of probability of pregnancy with certain prognostic factors in patients undergoing assisted reproductive technology in Russian population according to international and national guidelines.
- Trial name
- IRIS (NCT04249297)
- Testing
- Duphaston® (Dydrogesteron)
- Where
- 52 sites in Kazakhstan, Russia
- Volunteers
- 1,150 people
- Sponsor
- Abbott
Irregular Menstrual Cycle
Treatment Regimen in Menstrual Cycle Regularization and Persistence in Routine Clinical Practice in Russia, Ukraine, Kazakhstan and Uzbekistan
Dydrogesterone is approved in more than 100 countries including Russia, Ukraine, Kazakhstan and Uzbekistan and widely used for the treatment of progesterone deficiencies such as for management of dysmenorrhea, endometriosis…
- Trial name
- NCT01711216
- Where
- 66 sites in Kazakhstan, Russia and 2 more
- Volunteers
- 999 people
- Sponsor
- Abbott
Ovarian Endometrioma, Endometriosis
Guangdong Endometriosis Retrospective Clinical Cohort
This retrospective cohort study evaluates the association between postoperative hormonal treatment and recurrence of ovarian endometriosis in women undergoing surgery for ovarian endometrioma.
- Trial name
- NCT07519213
- Where
- China
- Volunteers
- 1,121 people
- Sponsor
- Guangdong Women and Children Hospital
Threatened Miscarriage, Early Pregnancy Bleeding
Comparison of Dydrogesterone Alone Versus Dydrogesterone Plus HCG in Threatened Miscarriage
This randomized controlled trial aims to compare the efficacy of Dydrogesterone alone versus Dydrogesterone combined with human chorionic gonadotrophin (HCG) in the treatment of threatened miscarriage in first trimester…
- Trial name
- DYD-HCG (NCT07608133)
- Testing
- Dydrogesterone, Human chorionic gonadotrophin (hCG)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Pakistan Air Force (PAF) Hospital Islamabad
Infertility, Female, Infertility, Male
Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles
The aim of this randomized controlled trial is to compare the efficacy of oral dydrogesterone vs. micronized vaginal progesterone for luteal phase support in frozen-thawed embryo transfer cycles.
- Conditions
- Infertility, Female, Infertility, Male, Embryo Transfer, Fertilization in Vitro
- Trial name
- NCT04124913
- Testing
- Dydrogesterone 10 MG Oral Tablet, Progesterone Vaginal Gel [Crinone]
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Memorial Sisli Hospital, Istanbul
Preterm Labor
Oral Dydrogesterone in the Management of Preterm Labor
This study evaluates the addition of oral dydrogesterone to standard treatment in the treatment of preterm labor. Half of participants will receive oral dydrogesterone and standard treatment, while the other half will receive…
- Trial name
- NCT03935152
- Testing
- Dydrogesterone
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Postmenopause
Vasomotoric Symptoms Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination
To demonstrate efficacy of continuous combined 0.5 mg estradiol and 2.5 mg dydrogesterone versus placebo in the treatment of vasomotor symptoms after a treatment period of 3 months and to investigate the bleeding pattern over a…
- Trial name
- NCT00251082
- Testing
- continuous combined estradiol and dydrogesterone
- Where
- 18 sites in Croatia, France and 3 more
- Volunteers
- 391 people
- Sponsor
- Solvay Pharmaceuticals
Miscarriage Threatening
Comparison of Dydrogesterone and Micronized Progesterone Treatments in the Treatment of Threatened Miscarriage.
In this study, we aimed to compare the effects of two drugs used for the threated miscarriage on the miscarriage rate.
- Trial name
- NCT05542797
- Testing
- Duphastone
- Volunteers
- 140 people
- Sponsor
- Konya Meram State Hospital
Endometrial Polyp
Dydrogesterone in the Treatment of Endometrial Polyps
This study is intended to observe the therapeutic effect of dydrogesterone on endometrial polyps and provide a reference for clinical treatment.
- Trial name
- NCT03790215
- Testing
- Dydrogesterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Menopausal Women, Menopausal Symptom Relief
Comparison of Oral Dydrogesterone and Vaginal Progesterone in Menopausal Hormone Therapy
Menopause is a natural stage in a woman's life that can be associated with symptoms such as hot flashes, night sweats, sleep problems, and vaginal dryness. Menopausal hormone therapy is commonly used to relieve these symptoms.
- Conditions
- Menopausal Women, Menopausal Symptom Relief, Hormone Therapy, Menopausal Hormone Therapy
- Trial name
- PRO-MHT (NCT07496294)
- Testing
- Dydrogesterone 10 MG Oral Tablet, Micronized progesterone 200 MG, Transdermal estradiol
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Perimenopausal Disorder, Hot Flashes
Comparative Study to Evaluate the Efficacy and Safety of the Fixed-dose Combination of Estradiol / Dydrogesterone in Perimenopausal Women
To obtain new data allowing personalizing continuous hormonal therapy in perimenopausal women in Russia, the following clinical study is going to be conducted in the Russian Federation:
- Trial name
- Violet (NCT05156814)
- Testing
- Femoston® 1, Femoston® 2, Duphaston, Klimadynon
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Scientific Research Institute of Public Health, Russian Federation
Ovary Cyst, Fertility Issues
Dydrogesterone-Primed Ovarian Stimulation Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in ICSI
GnRH antagonist protocol is currently a good strategy for controlled ovarian stimulation in women with PCOS undergoing IVF/ICSI cycles.
- Trial name
- NCT05751681
- Testing
- progestin primed ovarian stimulation protocol, dydrogesterone (Duphaston, Abbott), Cetrotide
- Where
- Egypt
- Volunteers
- 79 people
- Sponsor
- Zagazig University
Infertility, IVF
Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer
Randomized controlled study, open label to compare effectiveness of addition of dydrogesterone 20mg to the standard luteal phase support treatment after fresh embryos transfer.
- Trial name
- NCT04408144
- Testing
- Dydrogesterone 10mg Oral Tablet
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
InVitro Fertilization, Gonadotropins
rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
This study aims to compare two commonly used hormone treatments for women undergoing IVF. All participants will receive a stimulation protocol that includes dydrogesterone, a medication used to safely control natural hormone…
- Trial name
- DYG-GONA (NCT07348757)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center
IVF, PCO
Progesterone Primed Protocol Versus GnRH Antagonist in With PCO Undergoing ICSI
To compare the effectiveness and safety of Progesterone Primed Ovarian Stimulation protocol (PPOS) using Dydrogestrone vs GnRH Antagonist Protocol in patients with expected high ovarian response undergoing ICSI cycle
- Trial name
- NCT05951400
- Testing
- Dydrogesterone Tablets, Cetrorelix
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Infertility, Female, Fertility Disorders
DYG Versus Cetrorelix in Oocyte Donation
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day)…
- Trial name
- NCT05577806
- Testing
- Dydrogesterone
- Volunteers
- 202 people
- Sponsor
- Clinica de la Mujer Medicina Reproductiva, Chile
Endometriosis
Study of the Effectiveness of Dydrogesterone in the Treatment of Endometriosis-related Pain
The study is an observational, multicenter, prospective, single arm study to evaluate the efficacy of dydrogesterone in endometriosis-related pain (EAP).
- Trial name
- Daisy (NCT06952296)
- Testing
- Dydrogesterone
- Volunteers
- 250 people
- Sponsor
- Abbott
Menopausal and Postmenopausal Disorders
The Effect of Different Types of Progestin on Sleeping of Menopausal Women
Investigators have found that sleeping disorder is an important problem in menopausal women. There have been papers reporting the effect of hormonal therapy on sleeping, but fews have reported the effect of different progestogens…
- Trial name
- NCT02086032
- Testing
- 1mg 17 beta-estradiol, Dydrogesterone, micronized progesterone
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Infertility, Female, Infertility
Oral Dydrogesterone (OD) Versus Micronized Vaginal Progesterone (MVP) for Luteal Phase Support (LPS) in IVF/ICSI
Female inability to conceive a child. The purpose of this prospective randomized, double-blinded, double dummy, two-arm cross-over study is to investigate the difference on histological, transcriptional and immunological level in…
- Conditions
- Infertility, Female, Infertility, Genital Diseases, Male, Genital Diseases, Female
- Trial name
- NCT03677336
- Testing
- Dydrogesterone Oral Tablet, Micronized progesterone
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Pregnancy
Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage
The aim of this study is to determine whether the dydrogesterone therapy is associated with reduction in miscarriage in women with first trimester threatened miscarriage.
- Trial name
- NCT02128685
- Testing
- Dydrogesterone
- Where
- 3 sites in Hong Kong
- Volunteers
- 406 people
- Sponsor
- The University of Hong Kong