Clinical trials: Dysbarism
Saturation Exposure, Decompression Injury
Inflammatory and Cerebrospinal Biochemical Markers in Blood During Prolonged Hyperbaric Exposure
Research hypothesis Prolonged hyperbaric exposure will affect the central nervous system Prolonged hyperbaric exposure will induce inflammatory changes Prolonged hyperbaric exposure will affect fluid regulation in the body…
- Trial name
- Mättnad2017 (NCT03192930)
- Testing
- Hyperbaric exposure
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Sahlgrenska University Hospital
Barotrauma;Ear, Tympanum; Perforation
Effectiveness of Sequential Eustachian Tube Maneuvers in Hyperbaric Oxygen Conditions
Middle ear barotrauma represents the predominant complication associated with hyperbaric oxygen therapy, manifesting symptoms ranging from otalgia to tympanic membrane perforation.
- Trial name
- NCT06408363
- Testing
- Maneuver group
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Felicio Rocho
Auditory Diseases, Central
Comparing Hearing Aid Fitting Methods in Blast-exposed Veterans
Since 2000, at least 250,000 U.S. Service members have experienced a blast-related mild traumatic brain injury. A retrospective analysis of over 100,000 post-9/11 Veterans shows that blast injury more than doubles the risk of a…
- Trial name
- SBA (NCT06309264)
- Testing
- Phonak Lumina P90
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mechanical Ventilation
Continuous Monitoring of the Lungs Ventilation Dynamics During Mechanical Ventilation
Background: Patients that suffer from respiratory failure and need mechanical ventilation are at risk of further deterioration due to complications induced by progression of lung disease or the mechanical ventilation.
- Trial name
- NCT00702169
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Carmel Medical Center
Barotrauma;Ear, OME - Otitis Media With Effusion
Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT)
A prospective, multicenter study to evaluate effectiveness and safety of Tymbion iontophoresis and tympanostomy tube placement using the Tula iontophoresis and tube delivery systems for adults in an office setting.
- Conditions
- Barotrauma;Ear, OME - Otitis Media With Effusion, AOM - Acute Otitis Media, Eustachian Tube Dysfunction
- Trial name
- ADEPT (NCT03197558)
- Testing
- Tymbion Iontophoresis and Tube Delivery System (TDS)
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- Tusker Medical
Middle-ear Barotrauma
Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation
This study will determine if newly developed and more standard tests of Eustachian tube function can identify those persons who have ear pain (barotrauma) or develop middle-ear inflammation and/or fluid (barotitis) when they are…
- Trial name
- NCT01976429
- Testing
- flight/diving simulation, ET function testing at ambient pressure, nasal video-endoscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
COVID-19, Barotrauma
Barotrauma in Adults With Critical COVID-19
During the pandemic of COVID-19, studies reporting a high incidence of barotrauma, both pneumothorax but also pneumomediastinum, in patients with critical COVID-19.
- Trial name
- NCT05877443
- Testing
- Open system, Non-invasive mechanical ventilation, Invasive mechanical ventilation
- Where
- Sweden
- Volunteers
- 669 people
- Sponsor
- Karolinska Institutet
Decompression Sickness, Barotrauma
Health, Fitness, and Safety Knowledge as Determinants of Adverse Events in Recreational Divers in Poland
This cross-sectional online survey study assesses health status, physical fitness, and safety knowledge as potential determinants of diving-related adverse events among recreational divers in Poland.
- Conditions
- Decompression Sickness, Barotrauma, Recreational Diving
- Trial name
- DIVE-PL (NCT07855861)
- Testing
- Anonymous online questionnaire
- Where
- 2 sites in Poland
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Barotrauma, COVID-19
"Barotrauma in Admitted Covid-19 Cases - A Single Center Retrospective Study"
A retrospective study is planned to find out the incidence and association type of respiratory support with barotrauma in Covid-19 cases admitted in Sultan Qaboos University Hospital.
- Trial name
- BARCOV (NCT05216523)
- Where
- Oman
- Volunteers
- 251 people
- Sponsor
- Sultan Qaboos University
Barotrauma Epidemiology
Diver Ear, Nose and Throat Barotrauma Epidemiology
Ear, nose and throat barotrauma are the most frequently encountered accidents during diving. One study related to recreational diving reports that ENT barotrauma concern 10% of dives with experimented divers and 30% with novice…
- Trial name
- BTORL PAF (NCT04647591)
- Testing
- Questionnaires
- Where
- 7 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Blast Overpressure Exposure, Blast Injuries
Biomarkers of Brain Health in Blast Overpressure Exposure
The purpose of this study is to learn whether headsets that measure brainwaves can find early signs of changes in brain health in tactical operators who train near explosive blasts.
- Conditions
- Blast Overpressure Exposure, Blast Injuries, Brain Health, Occupational Exposure
- Trial name
- NCT07783048
- Testing
- Blast overpressure exposure during explosive breaching training
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Neurable, Inc
Post-Traumatic Stress Disorder, Blast Injury
Virtual Reality Therapy and Imaging in Combat Veterans With Blast Injury and Posttraumatic Stress Disorder
The main purpose of this study is to determine whether functional magnetic resonance imaging (fMRI), can distinguish between service members with and without traumatic brain injury (TBI), as well as those with posttraumatic…
- Trial name
- ViRTICo-BP (NCT01990547)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Otitic Barotrauma
Inner and Middle Ear Effects of Hyperbaric Oxygen Thrapy
Audiological evaluation performed to patients on hyperbaric oxygen therapy to see its effects on middle ear pressure
- Trial name
- NCT04186741
- Testing
- Hyperbaric oxygen
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Blast Injury
Precision Biomarkers to Detect Brain Injury in Active-Duty United States Special Operations Forces With Repeated Blast Exposure
This is a 4-year, longitudinal study of 100 active-duty Navy SEALs. The goal of the study is to determine whether repeated blast exposure affects SEAL brain health and to develop an initial diagnostic testing protocol that…
- Trial name
- NCT07131475
- Testing
- PBR28 TSPO PET
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Decompression Sickness
Rhu-pGSN to Mitigate Proinflammatory Responses to Decompression in Healthy SCUBA Divers
Healthy trained SCUBA divers will be randomized into three groups and exposed to a high-pressure profile in a hyperbaric chamber.
- Trial name
- NCT06216366
- Testing
- Sodium Chloride 0.9% Inj pre-exposure, Sodium Chloride 0.9% Inj post-exposure, Recombinant human plasma gelsolin pre-exposure
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- BioAegis Therapeutics Inc.
Blast Injuries, Traumatic Brain Injury
The Effects of Explosive Blast as Compared to Post-Traumatic Stress Disorder on Brain Function and Structure
Brain injury from explosive blast is a prominent feature of contemporary combat. Although protective armor and effective acute medical intervention allows soldiers to survive blast events, a growing number of veterans will have…
- Conditions
- Blast Injuries, Traumatic Brain Injury, Post-Traumatic Stress Disorders
- Trial name
- NCT00631436
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Center for Veterans Research and Education
Mild Traumatic Brain Injury
Symptom-Targeted Approach to Rehabilitation for Concussion
Throughout the course of the wars in Iraq and Afghanistan, more than 250,000 service members sustained traumatic brain injuries, mostly characterized as mild traumatic brain injuries (mTBI) or concussions.
- Trial name
- STAR-C (NCT05091970)
- Testing
- Manualized cognitive rehabilitation for mild traumatic brain injury (mTBI)
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- South Texas Veterans Health Care System
Wounds, Gunshot, Arm Injuries
Trial of Negative-pressure Wound Therapy Use in Conflict-related Extremity Wounds
There is a treatment method called negative-pressure wound therapy (NPWT) that is well established and used for the treatment of wounds.
- Conditions
- Wounds, Gunshot, Arm Injuries, Leg Injuries, Wound Infection
- Trial name
- VACoCREW (NCT02444598)
- Testing
- Vaccum Assisted Closure device, Conventional wound dressings
- Where
- 2 sites in Iraq, Jordan
- Volunteers
- 116 people
- Sponsor
- Karolinska Institutet
Pediatric ARDS
The Specific Elastance in ARDS Patients: a Pediatric Study
Aim of this study is to assess lung specific elastance in a population of pediatric patients with Acute Respiratory Distress Syndrome (ARDS) treated with mechanical ventilation, and in a pediatric population of ICU patients with…
- Trial name
- NCT02036801
- Testing
- Lung specific elastance
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Policlinico Hospital