Clinical trials: Dysbiosis
Precancerous Lesions
Beneficial Effects of Probiotics on Improvement of Gut Dysbiosis and Ascending Cholangitis in Patients Received Pancreaticoduodenectomy
To determine whether probiotics have beneficial effect on gut dysbiosis and postoperative ascending cholangitis in patients with pancreaticoduodenectomy.
- Trial name
- NCT06126432
- Testing
- Yugart
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Dysbiosis, Healthy
Investigation on the Efficacy of Oral Carnitine Challenge Test Based on a Gut Microbiota Functional Test
This study seeks to enlist healthy volunteers to form a validation cohort. The purpose is to confirm the observed correlations between the gut microbiome and the capacity to produce trimethylamine N-oxide (TMAO), which will be…
- Trial name
- NCT06175260
- Testing
- oral carnitine challenge test
- Where
- Taiwan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Dysbiosis
Effect of Agave Consumption on Performance and Gut Microbiota in Adults Undergoing Physical Training
The purpose of this study is to analyze changes in the gut microbiota of healthy adult athletes, both men and women, before and after supplementation with a dietary fiber (agavins).
- Trial name
- NCT07828093
- Testing
- Agavins
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- National Polytechnic Institute, Mexico
Periodontal Diseases, IBD
Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease
Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored.
- Conditions
- Periodontal Diseases, IBD, Dysbiosis, Inflammation
- Trial name
- NCT04790825
- Testing
- Full mouth scaling and root planing (FMSRP)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Dysbiosis
The Effect of Glucomannan Powder on Improving Gut Microbiota.
The object of this study is evaluating the effects of the Glucommanan on the healthy human subjects who are. In this trial, at most 30 healthy subjects whose ages are 20~65 years old (15 for placebo and 15 for intervention)will…
- Trial name
- NCT07231003
- Testing
- Glucomannan
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Axial Spondyloarthritis, Ankylosing Spondylitis
Fecal Microbiota Transplantation in Axial Spondyloarthritis
Although biologic therapy have revolutionized the treatment of Spondyloarthrtitis (SpA), many patients do not experience complete relief of SpA related complaints.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Dysbiosis, Spondyloarthritis
- Trial name
- MicroSpA (NCT06451588)
- Testing
- FMT
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- University Hospital of North Norway
Inflammatory Bowel Diseases, Parkinson Disease
Gut Microbiota Dysbiosis and Translocation During IBD and Parkinson
Inflammatory bowel diseases (IBD) and Parkinson disease (PD) are complex and multifactorial pathologies. Gut microbiota seems to play an active role.
- Trial name
- Medibiote1 (NCT04159727)
- Testing
- stool and blood analysis
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hôpital Européen Marseille
Pulmonary Arterial Hypertension
Angiotensin Converting Enzyme (ACE2), Brain, Gut Dysbiosis in Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is fatal with right heart failure due to raised pulmonary vascular pressure. Gut dysbiosis was identified in animals with pulmonary hypertension.
- Trial name
- NCT04104490
- Where
- 2 sites in United States, Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fertility, Infertility
New Strategies to Evaluate the Reproductive Tract Microbiome
The goal of this observational study is to evaluate alternative less invasive sampling methods for the analysis of the endometrial microbiome.
- Conditions
- Fertility, Infertility, Reproductive Health, Microbiome Analysis
- Trial name
- niMICROBIOME (NCT06920797)
- Testing
- Reproductive tract microbiome analysis
- Where
- Spain
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Igenomix
Spinal Cord Injury, Gut Dysbiosis
Gut Dysbiosis in Spinal Cord Injury Rehabilitation
The goal of this study is to investigate the role of gut microbiota, and related immune biomarkers and metabolites, in the functional recovery of spinal cord injury patients during the subacute phase.
- Conditions
- Spinal Cord Injury, Gut Dysbiosis, Immune Dysfunction
- Trial name
- SCIMBIONT (NCT06892106)
- Where
- Portugal
- Volunteers
- 106 people
- Sponsor
- Centro Academico Clínico Egas Moniz Health Alliance
Critical Illness, Dysbiosis
Influences of High-fiber, Organic Whole-food Formula on the Gut Microbiome in Critically Ill Children
This study evaluates the effects of either Pediasure or Nourish formulas on the gastrointestinal microbiome in critically-ill children. Patients will be randomized to received either Pediasure or Nourish.
- Conditions
- Critical Illness, Dysbiosis, Pediatric ALL
- Trial name
- NCT03414775
- Testing
- Nourish, Pediasure
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Gut Dysbiosis for TMAO Production From Red Meat Consumption
Development of Microbial Metabolism Gene Tests for Facilitating Precision Health and Preventive Medicine-Evaluation of TMAO Production in Human Body From High-carnitine Diet by Fecal Gbu Gene Testing
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to Trimethylamine n-oxide (TMAO) in the body by certain…
- Trial name
- NCT07322575
- Testing
- Beef
- Where
- Taiwan
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anorexia Nervosa
Discovering New Insights Into Anorexia Nervosa: Influence of MicrObial DysbiosiS (DIAMOnDS)
This study will investigate the link between the gut microbiota, the occurrence of the central adiposity phenotype, and the patients' fear to regain weight in anorexia nervosa.
- Trial name
- DIAMOnDS (NCT06043154)
- Testing
- Patients with severe to extreme anorexia nervosa admitted to hospital for refeeding
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Weight Gain, Pregnancy, Microbial Colonization
Microbiome and Malnutrition in Pregnancy (MMiP)
Nutritional status during pregnancy plays an important role in maternal health and birth outcomes. While few factors impacting nutritional status during pregnancy have been identified, studies of undernutrition in children have…
- Conditions
- Weight Gain, Pregnancy, Microbial Colonization, Pregnancy Related, Pregnancy Loss
- Trial name
- MMiP (NCT05108675)
- Where
- Pakistan
- Volunteers
- 400 people
- Sponsor
- Aga Khan University
Vaginitis, Dysbiosis
Oral Multi-Strain Lactobacillus Probiotic for Women With Vaginal Dysbiosis
Many women have an imbalance in their vaginal bacteria that can cause discomfort, irritation, and repeat infections. In a healthy vagina, helpful Lactobacillus bacteria are the main group of microbes.
- Conditions
- Vaginitis, Dysbiosis, Vaginal Diseases
- Trial name
- NCT07882134
- Testing
- Low-dose multi-strain Lactobacillus capsule, High-dose capsule
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- Soon Chun Hyang University
Chronic Periodontitis, Periodontal Bone Loss
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
- Conditions
- Chronic Periodontitis, Periodontal Bone Loss, Resistance Bacterial
- Trial name
- NCT03863249
- Testing
- SCALE AND ROOT PLANING, ADJUNTIVE ANTIBIOTICS, MICROBIAL SAMPLING
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- University of Valencia
Dysbiosis, Endotoxemia
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
This study evaluates dietary green tea extract to improve gut health and inflammation in persons with metabolic syndrome and healthy adults.
- Conditions
- Dysbiosis, Endotoxemia, Metabolic Syndrome, Inflammation
- Trial name
- NCT03973996
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Endometrial Receptivity
Microbiome and Endometrial Receptivity in Obese Infertile Women
The objective of this project is the identification and quantification of the main bacterial communities present in the endometrial microbiota in obese infertile patients, to assess if there is an alteration of their composition…
- Trial name
- NCT03493529
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Inflammatory Bowel Diseases, Ulcerative Colitis
Vitamin D Regulation of Gut Specific B Cells and Antibodies Targeting Gut Bacteria in Inflammatory Bowel Disease
Specific Aim 1: Characterize the effects of vitamin D treatment on expression of α4β7 on B cells in patients with inflammatory bowel disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT04828031
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University