Clinical trials: Dysfunction
STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction
Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Myocardial Dysfunction, Percutaneous Coronary Intervention
- Trial name
- NCT05160311
- Testing
- Optimized Medical Treatment (OMT), Drug Eluting Stent (DES) Coronary Angioplasty
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Anosognosia, Alzheimer's Disease
Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)
This is a three year fMRI study conducted at the University of Wisconsin (UW) Hospital and the William. S. Middleton VA Hospital.
- Conditions
- Anosognosia, Alzheimer's Disease, Mild Cognitive Impairment
- Trial name
- NCT00908999
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sacroiliac Joint Dysfunction
SI Joint Fusion and Decortication Using the SImmetry System
The purpose of the SI Joint Fusion and Decortication Using the SImmetry System study is to evaluate the SImmetry Sacroiliac Joint Fusion System for fusion of the SI joint and relief of SI joint pain symptoms.
- Trial name
- NCT02560714
- Testing
- SImmetry Sacroiliac Fusion System
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Zyga Technology, Inc.
Migraine
Migraine Induction Properties of PACAP-38 After Eptinezumab in Migraine Without Aura Patients.
To investigate whether administration of calcitonin gene-related peptide (CGRP) binding monoclonal antibodies eptinezumab prevents pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) induced migraine attacks in…
- Trial name
- NCT05635604
- Testing
- Eptinezumab, PACAP-38
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Danish Headache Center
Mild Cognitive Impairment
Lifestyle Intervention Program for Cognitive Impairment
The purpose of the Lifestyle Intervention Study is to investigate the influence of a micronutrient supplement in combination with a comprehensive lifestyle intervention program on retinal amyloid, among patients with Mild…
- Trial name
- NCT02741804
- Testing
- BBH-1001 Brain Health Supplement, Lifestyle Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Cedars-Sinai Medical Center
Alzheimer Disease, Mild Cognitive Impairment
Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans
This study will investigate the performance of physician readers trained to read florbetapir-PET scans using electronic media training.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Neurodegenerative Diseases
- Trial name
- NCT01550549
- Testing
- florbetapir F 18
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Heart Failure With Preserved Ejection Fraction, Left Ventricular Diastolic Dysfunction
Invasive Left Heart Catheterization Registry
Retrospectively enrolled suspicious of heart failure with preserved ejection fraction (HFpEF) patients who underwent left heart catheterization with the measurement of left ventricular end-diastolic pressure.
- Trial name
- NCT04505449
- Testing
- Left heart catheterization
- Where
- South Korea
- Volunteers
- 404 people
- Sponsor
- Samsung Medical Center
Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease
Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease
This project aims to longitudinally profile plasma-derived GDEVs and plasma biomarkers of neuroinflammation across three stages of the AD continuum (Subjective Cognitive Decline, Mild Cognitive Impairment, and Alzheimer's…
- Conditions
- Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Alzheimer's Disease Dementia, Alzheimer's Disease (AD)
- Trial name
- GLEVAD (NCT07803055)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder
The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery
RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive…
- Conditions
- Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder, Cardiac Surgery, Major Surgery Under General Anesthesia
- Trial name
- INOCS (NCT07200726)
- Testing
- Observational study design - no intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Ziekenhuis Oost-Limburg
Executive Dysfunction
Improving Self-regulation & School Readiness in Preschoolers
This project will develop and evaluate the initial effectiveness of an intervention training executive functioning, metacognition, and self-regulation in preschoolers attending certain high poverty Cincinnati preschools.
- Trial name
- NCT02225236
- Testing
- Classroom Intervention
- Where
- United States
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Insomnia, Cognitive Disorder
Study on Cognitive Impairment of Insomnia Based on MRI
Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment.
- Conditions
- Insomnia, Cognitive Disorder, MRI
- Trial name
- NCT05659511
- Testing
- MRI
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Covid19, Endothelial Dysfunction
Managing Endothelial Dysfunction in Critically Ill COVID-19 Patients at LAUMCRH
COVID-19 Infection has been found to cause endothelial dysfunction and most of the adverse events stem to this mechanism. So we seek to target endothelial dysfunction in critically Ill patients with covid by giving them an…
- Trial name
- NCT04813471
- Testing
- Endothelial Protocol
- Where
- Lebanon
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lebanese American University Medical Center
Eustachian Tube Dysfunction
The Accuracy of Sonotubometry to Assess the Eustachian Tube
The Eustachian tube (ET) connects the middle ear with the throat and is important for maintaining a healthy middle ear. Sonotubometry is a new method to measure how well the ET works by using sound.
- Trial name
- NCT05740384
- Testing
- Sonotubometry Assessment
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- James Tysome
Urinary Dysfunction, Sexual Dysfunction
Sexual and Urinary Function Improvement for Cancer Survivors
The purpose of this study is to test the efficacy of SUFICS-PACT to identify and treat sexual and urinary dysfunction in prostate cancer survivors at NYC H+ H/Bellevue, the oldest public hospital in the US.
- Trial name
- NCT06637852
- Testing
- SUFICS-PACT
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Early Triple Negative Breast Cancer
BRCA1-associated DNA Repair Dysfunction in Patients With Early Triple Negative Breast Cancer Treated With Neoadjuvant Platinum-based Chemotherapy
The purpose of this study is to assess efficacy of platinum-based neoadjuvant chemotherapy in correlation with BRCA1-associated DNA repair dysfunction in patients with early triple negative breast cancer.
- Trial name
- NCT01672671
- Testing
- Doxorubicin, Paclitaxel, Cisplatin
- Where
- Russia
- Volunteers
- 41 people
- Sponsor
- Russian Academy of Medical Sciences
Multisystemic Smooth Muscle Dysfunction Syndrome
A Single Patient Study of Sapropterin for Multisystem Smooth Muscle Dysfunction Syndrome
There is currently no approved treatment for multisystem smooth muscle dysfunction syndrome (MSMDS). This single-patient study is the first to be conducted in a child with MSMDS in Canada and was designed to provide the child…
- Trial name
- NCT07574034
- Testing
- Kuvan (Sapropterine)
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Gregor Andelfinger
Posterior Blepharitis
Topical IL-1-Ra for Treatment of Posterior Blepharitis
The purpose of this study is to determine the effectiveness and safety of Topical Interleukin-1-Receptor Antagonist in treatment of signs and symptoms of posterior blepharitis.
- Trial name
- NCT00681109
- Testing
- 2.5% IL-1Ra, 5% IL-1Ra
- Volunteers
- 75 people
- Sponsor
- Reza Dana, MD
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Long Term Follow up of Children Enrolled in the REDvent Study
This is a prospective observational follow-up study of children enrolled in a single center randomized controlled trial (REDvent).
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury, Neurocognitive Dysfunction, Quality of Life
- Trial name
- NCT03709199
- Testing
- Ventilation Inhomogeneity, Diaphragm Ultrasound, Respiratory Inductance Plethysmography
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Children's Hospital Los Angeles
Beta-Thalassemia
Thrombophilia In Beta Thalassemia
β-thalassemia disease is one of the most common congenital hemolytic anemia commonly found in the malarial belt areas including the Mediterranean, the Middle East, Africa, Southeast Asian countries, and China.
- Trial name
- NCT04219449
- Testing
- PT, Protein C, Platelet aggregation by ADP and arachidonic acid
- Volunteers
- 100 people
- Sponsor
- Assiut University
Postoperative Delirium, Postoperative Cognitive Dysfunction
Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperative Cognitive Assessment Tool
This observational cohort study is designed to validate the CogCheck application as a risk prediction tool for postoperative delirium in patients undergoing cardiac surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- CogCheck-Valid (NCT03360838)
- Testing
- CogCheck
- Where
- Switzerland
- Volunteers
- 475 people
- Sponsor
- University Hospital, Basel, Switzerland