Clinical trials: Dysfunction
Bipolar Disorder
A Trial of Functional Remediation in Patients With Bipolar Disorder
In the last decade several evidences show that cognitive impairment is a major feature of bipolar disorder (BD), that is strongly associated with patients' functional outcome.
- Trial name
- NCT04577508
- Testing
- Functional Remediation, Treatment as usual
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Bladder Tumor, Postoperative Cognitive Dysfunction
The Assessment of POCD After TURBT Under Spinal Anesthesia
This study evaluates the influence of premedication on cognitive functions in patients undergoing transurethral resection of bladder tumor under spinal anesthesia.
- Trial name
- NCT03029676
- Testing
- benzodiazepines, opioid, spinal anesthesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Seizure Disorder, Hypogonadism
Treatment of Sexual Dysfunction in Hypogonadal Men With Epilepsy With Testosterone and Either Anastrozole or Placebo
The purpose of this study is to determine if treatment using a medication (anastrozole/Arimidex), which lowers estrogen levels in the blood is better than placebo, a tablet that does not contain any active medication, when…
- Conditions
- Seizure Disorder, Hypogonadism, Erectile Dysfunction
- Trial name
- NCT00179517
- Testing
- Anastrozole 1mg
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Deaconess Medical Center
Obstructive Sleep Apnea
Brain Fog in Sleep Apnea
Objective: This observational, cross-sectional pilot study aims to assess "Brain Fog" (cognitive symptoms impacting memory, attention, and concentration) in severe Obstructive Sleep Apnea (OSA) patients.
- Trial name
- BF -OSA (NCT06664450)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Pulmonary Embolism
Short-term Clinical Deterioration After Acute Pulmonary Embolism
This is a prospective, observational, multicenter cohort study to compare right ventricular dysfunction dependent and independent prognostic models for short-term serous adverse events in patients who are diagnosed with pulmonary…
- Trial name
- NCT03915925
- Where
- 6 sites in United States
- Volunteers
- 935 people
- Sponsor
- Wake Forest University Health Sciences
Dementia Alzheimers, Dementia With Lewy Bodies
Dementias and Microbiota Composition: Is Possible to Revert the Dementia Symptoms Reverting the Microbiota Composition?
Dementia is the major cause of disability and dependency among older adults worldwide affecting memory, cognitive abilities and behavior, interfering with one's ability to perform daily lives activities.
- Conditions
- Dementia Alzheimers, Dementia With Lewy Bodies, Parkinson Disease Dementia, Dementia Frontotemporal
- Trial name
- DEM-BIOTA (NCT05943925)
- Testing
- No intervention, Probiotic supplement
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Chronic Obstructive Pulmonary Disease, COPD
Antioxidants and Pulmonary Rehabilitation in COPD Patients
On the basis of published data and investigators results indicating that systemic redox in balance may contribute to the peripheral muscle dysfunction in COPD patients, the investigators propose a study testing the effects of…
- Trial name
- AREB-1 (NCT01942889)
- Testing
- Antioxidant Supplementation associated to Comprehensive respiratory Rehabilitation Program
- Where
- 2 sites in France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Montpellier
Hypercholesterolemia, Hypertension
Nutritional Intervention With Black Garlic
A controlled clinical intervention study is proposed to determine the effect of black garlic consumption on biomarkers of cardiovascular function and associated pathologies in a healthy population at risk for cardiovascular…
- Conditions
- Hypercholesterolemia, Hypertension, Hyperlipidemias, Inflammation
- Trial name
- NCT05082350
- Testing
- black garlic
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maria Pilar Zafrilla Rentero
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Erectile Dysfunction, Type 1 Diabetes Mellitus
Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes
The intent of this clinical study is to answer the questions: 1) is the proposed treatment feasible; 2) is treatment effective in improving the disease pathology of patients with diagnosed diabetic erectile dysfunction.
- Conditions
- Erectile Dysfunction, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- NCT02579148
- Testing
- HUCMSC injection, collagen scaffolds/HUCMSC injection
- Where
- China
- Sponsor
- Leilei Zhu
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Congestive Heart Failure, Cognitive Impairment
Cognitive Training in Heart Failure Study (CogTrain-HF)
The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention.
- Trial name
- CogTrain-HF (NCT02415517)
- Testing
- Cognitive training, Test of general knowledge
- Where
- 2 sites in Germany
- Volunteers
- 107 people
- Sponsor
- Universität des Saarlandes
Cardiopulmonary Bypass, Cardiovascular Diseases
Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg.
- Conditions
- Cardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac Surgery
- Trial name
- PANDA (NCT06707350)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Meibomian Gland Dysfunction, Blepharitis
Analysis of the Results of Intense Pulsed Light Treatment Previously to Laser Refractive Surgery
Dry eye is often reported as the most common complication after a laser refractive surgery. Any refractive procedure can lead an impact on the corneal surface and the tear film.
- Trial name
- NCT05139511
- Testing
- Study group, Control group
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vissum, Instituto Oftalmológico de Alicante
Lower Urinary Tract Symptoms
The Effect of Repetative Transcranial Magnetic Stimulation Therapy for Stroke Patients
The aim of our study is to investigate the effect of repetitive transcranial magnetic stimulation therapy (rTMS) on lower urinary system dysfunctions and detrusor muscle activity in stroke patients.
- Trial name
- NCT05738863
- Testing
- Low Frequency rTMS Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Afyonkarahisar Health Sciences University
Sickle Cell Disease
Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients
This study objectives to assess the role of endothelial monocyte-activating polypeptide II (EMAP II) as a marker of endothelial dysfunction and disturbed angiogenesis in sickle cell disease and to identify its correlation With…
- Trial name
- NCT03903133
- Testing
- Vitamin E
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
To Evaluate the Tolerability, Pharmacokinetics, and Pharmacodynamics of IMM-H014 in Patients With MASH
This study will evaluate the tolerability, pharmacokinetics, and pharmacodynamics of consecutive Multiple treatment for 12 weeks（84 Days） in Adult Patients with Metabolic Dysfunction-Associated Steatohepatitis.
- Trial name
- NCT07016633
- Testing
- IMM-H014
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Changchun Intellicrown Pharmaceutical Co. LTD
Aging, Cognitive Decline
The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT)
Tremendous progress has been made in characterizing the interactions between the central nervous system and the gastrointestinal tract.
- Trial name
- COMBAT (NCT03679533)
- Testing
- Freeze-Dried Cranberry Powder
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Postoperative Cognitive Dysfunction
Effect of Ciprofol Injection on Postoperative Cognitive Function
This study aims to explore the effect of ciprofol on the postoperative cognitive function of inpatients undergoing gastrointestinal endoscopy examination, to compare the anesthetic effects and differences in adverse reactions of…
- Trial name
- NCT07673978
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Infertility, Female
Sequential Therapy of TCM Herbs to Improve the Success Rate of IVF-ET in Diminished Ovarian Reserve Patients
In the early stage, our team found that traditional Chinese medicine (TCM) intervention aimed at Nourishing kidney and regulating blood circulation in vitro fertilization and embryo transfer(IVF-ET) can improve the clinical…
- Trial name
- NCT04842825
- Testing
- Er Zhi Wan combined with Si Wu Tang, Recombinant Human Follitropin Alfa 、Fructose 、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital