Clinical trials: Dyskinesia
Rehabilitation, Neck Pain
Work Place Adjusted Intelligent Physical Exercise Reducing Musculoskeletal Pain in Shoulder and Neck (VIMS) - Shoulder Function
Basic strength training for the neck/shoulder muscles can decrease intensity of neck/shoulder pain, but it is uncertain whether training should focus directly on the upper trapezius - which is most often tender - or on the lower…
- Conditions
- Rehabilitation, Neck Pain, Shoulder Pain, Scapular Dyskinesis
- Trial name
- VIMS03 (NCT01205542)
- Testing
- Training, Reference
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Huntington Disease
Feasibility of a Video-oculography in Patients With Huntington's Disease VOG-HD Study
The purpose of this study is to know the limits of feasibility of a reliable oculomotor record for patient with Huntington's disease.
- Trial name
- VOG-HD (NCT02563418)
- Testing
- Eye-tracking
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Huntington Disease
Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease
WVE-HDSNP2-002 is an open-label extension (OLE) study to evaluate the safety, tolerability, PK, PD, and clinical effects of WVE-120102 in adult patients with early manifest HD who carry a targeted single nucleotide polymorphism…
- Trial name
- NCT04617860
- Testing
- WVE-120102
- Where
- 20 sites in Australia, Canada and 5 more
- Volunteers
- 36 people
- Sponsor
- Wave Life Sciences USA, Inc.
Ataxia Telangiectasia, Dysmetria
Videoocular Assessment of Eye Movement Activity in an Ataxia Telangiectasia
Ataxia-telangiectasia (A-T) is a multisystem auto-somal recessive disorder linked to the A-T mutated gene (ATM) on chromosome 11q22-23, and characterized by progressive neural degeneration, immunodeficiency, and progressive…
- Trial name
- NCT05471310
- Where
- Russia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Dystonia; Orofacial
Outcome of Botulinum Toxin Treatment for Oromandibular Dystonia
Symptoms of oromandibular dystonia can be alleviated by injections of botulinum toxin. The scope of this study is to describe the efficacy of this procedure, by a retrospective systematic review of patients medical charts
- Trial name
- rétroBODOM (NCT03363113)
- Testing
- Botulinum Toxins
- Volunteers
- 240 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank…
- Trial name
- NCT05766813
- Testing
- Lenrispodun
- Where
- 35 sites in United States
- Volunteers
- 79 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Parkinson Disease
A Clinical Study of IRL790 in Patients With Parkinson's Disease Experiencing Levodopa Induced Dyskinesia
This is a Phase 1b study investigating the safety and tolerability of IRl790 as adjunct therapy in patients with Parkinson disease. IRL790/placebo is taken for 28 days.
- Trial name
- NCT03531060
- Testing
- IRL790
- Volunteers
- 15 people
- Sponsor
- Integrative Research Laboratories AB
Huntington Disease
Ursodiol in Huntington's Disease
The purpose of this study is to evaluate the safety of the drug ursodiol (ursodeoxycholic acid, UDCA) in people with Huntington's disease (HD) and to explore how the compound is processed by the body.
- Trial name
- UDCA-HD (NCT00514774)
- Testing
- ursodiol
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Dementia Moderate, Dementia Severe
Dronabinol for Agitation in Dementia Crossover Trial
The goal of this clinical trial is to study the effects of dronabinol in US Veterans with agitation related to moderate to severe dementia.
- Conditions
- Dementia Moderate, Dementia Severe, Agitation,Psychomotor, Behavioral Symptoms
- Trial name
- NCT05612711
- Testing
- Dronabinol
- Where
- United States
- Sponsor
- Ralph H. Johnson VA Medical Center
Dystonia
Vercise™ DBS Dystonia Prospective Study
To compile characteristics of real-world outcomes of Boston Scientific Corporation's commercially approved VerciseTM Deep Brain Stimulation (DBS) Systems for the treatment of dystonia.
- Trial name
- NCT02686125
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 36 sites in Belgium, Canada and 10 more
- Volunteers
- 300 people
- Sponsor
- Boston Scientific Corporation
Huntington Disease
A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease (HD)
The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 compared with placebo in participants with HD.
- Trial name
- NCT05358717
- Testing
- PTC518
- Where
- 28 sites in United States, Australia and 9 more
- Volunteers
- 159 people
- Sponsor
- Novartis Pharmaceuticals
Agitation in Adolescents and Young Adults With ASD
INP105 Proof-of-concept Study for the Acute Treatment of Agitation in Adolescents and Young Adults With ASD
This is a Phase 2a, proof-of concept, 2-way, 2-period crossover, double-blind study to evaluate the safety and efficacy of INP105 as an acute treatment versus placebo in adolescents and young adults with autism spectrum disorder…
- Trial name
- CALM 201 (NCT05163717)
- Testing
- INP105
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Impel Pharmaceuticals
Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy
The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders
People with Parkinson's disease (PD) commonly experience a range of both motor (e.g., bradykinesia, rigidity, tremor, and postural instability) and non-motor (e.g., fatigue, psychiatric and behavioural disturbances, autonomic…
- Conditions
- Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Different Types of Tremor Including Essential Tremor, Dystonia
- Trial name
- NCT06174948
- Testing
- CUE1 non-invasive device
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Agitation,Psychomotor
Olanzapine Versus Midazolam for Agitation
The goal of this research investigation is to conduct a prospective observation of the comparative efficacy of midazolam versus olanzapine for the treatment of acute undifferentiated agitation in the emergency department.
- Trial name
- OvM (NCT03899506)
- Testing
- Olanzapine, Midazolam
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Hennepin Healthcare Research Institute
Essential Tremor, Parkinson Disease
The Essential Tremor (ET) and Parkinson Disease (PD) Tremor Acute Stimulation Study
The current study is designed to test the hypothesis that targeted electrical stimulation will result in upper limb tremor reduction in ET and PD patients.
- Trial name
- NCT01940406
- Testing
- Stimulation procedure
- Where
- Israel
- Sponsor
- BlueWind Medical
Bipolar Disorder
SALT Study (Switching to the Administration of Lithium Slow -Release Treatment)
The aim of the study is to assess the tolerability, efficacy and safety of a new lithium sulphate prolonged release formulation (Lithiofor®) in patients affected by Bipolar Disorder poor tolerant to lithium immediate-release…
- Trial name
- NCT03210480
- Testing
- Lithium sulphate prolonged-release 660 mg, Lithium carbonate immediate-release 150 mg and 300 mg
- Where
- 6 sites in Italy
- Volunteers
- 85 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Cervical Dystonia
Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
The most common form of idiopathic dystonia is adult-onset cervical dystonia (CD), a focal form of dystonia affecting the muscles of the neck.
- Trial name
- NCT06771323
- Testing
- Valbenazine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Huntington Disease
Impact of Apathy on Caregiving in HD. Version 1
Huntington's disease (HD) can affect motivation. People with HD may not wash often, keep their house clean and tidy, or eating healthy food.
- Trial name
- NCT05913154
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Parkinson Disease, Subthalamic Nucleus Stimulation
Subthalamic Nucleus Stimulation With Directional Leads on Patients With Parkinson Disease at Fluctuations and Dyskinesia Stage
Patients with subthalamic nucleus have to go through a lot of examinations and tests, before and after surgery which is difficult, sometimes painful, for the patient.
- Conditions
- Parkinson Disease, Subthalamic Nucleus Stimulation, Directional Electrodes
- Trial name
- NSTBOS (NCT05103072)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Dystonia
Dystonia Coalition Projects
Dystonia is a disorder characterized by excessive involuntary contraction of muscles with repetitive and patterned movements. The primary focal dystonias are the most common type of dystonia and include Limb dystonias (like…
- Trial name
- NCT04156022
- Testing
- Dystonia Coalition is an observational study.
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
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