Clinical trials: Dyskinesia
Huntington's Disease
Multicentric Trial of the Treatment of Huntington's Disease by Cysteamine (RP103)
The purpose of this study is to evaluate the effect of cysteamine in patients with symptomatic Huntington's disease by comparing two groups of patients (cysteamine vs placebo) on the results of the Unified Huntington's Disease…
- Trial name
- NCT02101957
- Testing
- RP103
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Angers
Stroke, Cerebrovascular Accident
AMES Treatment of the Proximal Arm in Chronic Stroke
Subjects will receive 30 treatments with AMES, to the proximal arm which has been affected by a chronic stroke.
- Trial name
- AMES (NCT01934439)
- Testing
- 30 PAAD treatments
- Where
- United States
- Sponsor
- Oregon Health and Science University
Primary Ciliary Dyskinesia (PCD)
Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance
This is a multi-dose study with RCT1100 and is designed to provide safety, tolerability and preliminary efficacy data for future clinical studies.
- Trial name
- NCT06633757
- Testing
- RCT1100
- Where
- 3 sites in United States, Denmark and 1 more
- Volunteers
- 14 people
- Sponsor
- ReCode Therapeutics
Torticollis, Muscle Spasticity
Botulinum Toxin Injection Efficiency
The purpose of the study is to examine the effect of the botulinum toxin injection into muscle tone, strength and mobility with and without muscle exercise effect.
- Trial name
- NCT01041157
- Testing
- Resistance training
- Where
- Finland
- Volunteers
- 22 people
- Sponsor
- Jyväskylä Central Hospital
Cerebellar Ataxia
Augmenting Balance in Individuals With Cerebellar Ataxias
This study evaluates the effectiveness of a 12-week in home balance training program with and without sensory augmentation for individuals with ataxia.
- Trial name
- NCT02887703
- Testing
- Sensory Augmentation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kathleen Sienko
Dystonia, Muscle Hypertonia
Quantification of Upper Extremity Hypertonia
Dr. Sanger and the research team want to learn about upper extremity hypertonia (stiffness) in children and young adults with cerebral palsy.
- Trial name
- NCT00285870
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Ataxia
Autoimmunity in Neurologic Complications of Celiac Disease
This study, done in collaboration with Cornell University in New York, will explore the potential role of the body s immune response to gluten in ataxia.
- Trial name
- NCT00692861
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome
Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission
A joint NIH -Tourette Syndrome Association Conference has emphasized the critical need for the testing and development of new pharmacotherapy for tic suppression in Tourette syndrome (TS).
- Trial name
- NCT01018056
- Testing
- D-serine, Riluzole
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Johns Hopkins University
Parkinson Disease, Dystonia
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
Transcranial Ultrasound Stimulation (TUS) is an emerging non-invasive brain stimulation technique capable of targeting both superficial and deep brain areas with high spatial resolution, down to a few cubic millimeters.
- Trial name
- NCT06232629
- Testing
- TUS Active
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Cervical Spine Degeneration, Movement, Abnormal
Cervical Spine Motion in the Elderly
Rationale: Physiological motion of the cervical spine is a subject of interest for medical specialists. Segmental range of motion (sROM) has been most commonly used to define motion but inter- and intra-variability is large.
- Conditions
- Cervical Spine Degeneration, Movement, Abnormal, Aging
- Trial name
- NCT04222777
- Testing
- Cinematographic Recording
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Huntington's Disease
Social Cognition in Huntington's Disease: Cognitive Study and Functional and Morphological Imaging
Huntington's disease is a rare genetic neurodegenerative disease. It is accompanied by movement disorders, cognitive and behavioral. The social behavior of patients are changed, affecting interpersonal relationships.
- Trial name
- COSIMH (NCT02550275)
- Testing
- neuropsychological test, MRI
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Medication-Induced Dyskinesia
Study to Assess the Safety, Tolerability and Preliminary Efficacy of NLX-112 Versus Placebo in L-dopa-induced Dyskinesia
This is a double-blind, randomized, placebo-controlled Phase 2a study evaluating the safety, tolerability, and preliminary efficacy of up to 2 mg/day (1 mg BID) of NLX-112 versus placebo in patients with moderate to severe L-DOPA…
- Trial name
- NCT05148884
- Testing
- NLX-112
- Where
- 5 sites in Sweden
- Volunteers
- 27 people
- Sponsor
- Neurolixis SAS
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Dystonia
Efficacy and Safety of Radiofrequency Pallidotomy in the Management of Dystonia
Generalized dystonia is treated with pallidotomy. This is based on observational data which is significantly limited by publication bias and there are no RCTs.
- Trial name
- NCT06038097
- Testing
- Radiofrequency Pallidotomy
- Where
- India
- Volunteers
- 72 people
- Sponsor
- All India Institute of Medical Sciences
Non Invasive Prenatal Diagnosis
NIPD on CFTC for Triplet Repeat Diseases
The purpose of this study is to develop and validate an analytical and clinical NIPD test for triplet repeat diseases by isolated circulating fetal trophoblastic cells (CFTC) analysis from maternal blood, searching for the…
- Trial name
- DIACCIMEX (NCT03087526)
- Testing
- Non invasive prenatal diagnosis
- Where
- 8 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Blepharoptosis, Synkinesis
Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis
After an episode of facial paralysis, as nerves recover, they aberrantly regenerate and send additional branches to the incorrect muscles in addition to the intended muscle.
- Conditions
- Blepharoptosis, Synkinesis, Hyperkinesis, Facial Paralysis
- Trial name
- NCT05945615
- Testing
- Oxymetazoline 0.1% (Pf) Oph Soln Ud, Preservative free lubricating drops
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Sydenham Chorea, Post Streptococcal Movement Disorder
Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea
Children are at risk of developing an involuntary movement disorder after streptococcal throat infections. Not all children are affected and the severity is individually variable.
- Trial name
- NCT00615797
- Testing
- Intravenous immunoglobulin, standard interventions penicillin VK and haloperidol
- Where
- South Africa
- Volunteers
- 20 people
- Sponsor
- University of Cape Town
Tardive Dyskinesia
Melatonin Treatment for Tardive Dyskinesia in Schizophrenia
This is a double-blind, randomized, placebo-controlled trial of melatonin as an add-on therapy to antipsychotics will be performed to examine the effects of melatonin on tardive dyskinesia symptoms and cognitive deficits in 120…
- Trial name
- NCT01391390
- Testing
- Melatonin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing HuiLongGuan Hospital
Parkinson Disease, Tremor
Istradefylline Effect Protocol on Parkinson's Disease Tremor
This is an investigator-initiated trial. In this 6-month open label, single arm, exploratory pilot study, the investigator intends to enroll a pilot sample of 25 patients with Parkinson's disease who are being started on the…
- Trial name
- NCT05885360
- Testing
- Istradefylline Pill
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Georgetown University
Huntington Disease
Efficacy of Deutetrabenazine to Control Symptoms of Dysphagia Associated with HD
To determine the efficacy of deutetrabenazine to control symptoms of dysphagia associated with HD.
- Trial name
- NCT04301726
- Testing
- Deutetrabenazine Oral Tablet [Austedo]
- Where
- Puerto Rico
- Volunteers
- 36 people
- Sponsor
- Fundacion Huntington Puerto Rico
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.