Clinical trials: Dyskinesia
Injury Brain, Eye Abnormalities
Reading Problems Associated With Central Nervous System (CNS) Pathologies.
This project aims to analyse eye movements, their alterations and influence in reading performance in patients with acquired CNS diseases and compare them with people of the same age, without neurological or ocular pathology and…
- Conditions
- Injury Brain, Eye Abnormalities, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT04937725
- Testing
- eye tracking
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Blepharospasm, Dystonia
Exploratory Study of Dipraglurant (ADX48621) for the Treatment of Patients With Blepharospasm
This study is designed to assess the safety and tolerability of dipraglurant in patients with blepharospasm (BSP) (randomized 1:1:1 to receive dipraglurant 50 mg, 100 mg or placebo) and explore the efficacy of 50 mg and 100 mg…
- Trial name
- NCT05027997
- Testing
- Dipraglurant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Addex Pharma S.A.
Huntington's Disease
Safety and Efficacy of OMS643762 in Subjects With Huntington's Disease
The purpose of this study is to determine the safety, tolerability and pharmacokinetics of OMS643762 (the study drug) in subjects with Huntington's disease (HD).
- Trial name
- NCT02074410
- Testing
- OMS643762
- Where
- 9 sites in United States
- Volunteers
- 22 people
- Sponsor
- Omeros Corporation
Tremor
Effect of Alcohol on Tremors
Tremors are involuntary movements of a part or parts of the body that occur because of alternating contraction and relaxation of muscles. The causes behind most tremors are poorly understood.
- Trial name
- NCT00001925
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Delirium, Critical Illness
Goal-Directed Sedation in Mechanically Ventilated Infants and Children
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs.
- Conditions
- Delirium, Critical Illness, Sedation Complication, Executive Dysfunction
- Trial name
- mini-MENDS (NCT04801589)
- Testing
- Dexmedetomidine, Midazolam
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- Vanderbilt University Medical Center
Creation of an Italian Network of Biobanks of Rare Diseases
ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria
Rare diseases (RDs) have been defined by the European Union (EU) as life-threatening or chronically debilitating conditions affecting less than 1 person in 2000.
- Trial name
- SATELLITES (NCT06782230)
- Where
- Italy
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Tourette Syndrome, Obsessive-Compulsive Disorder
Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what…
- Conditions
- Tourette Syndrome, Obsessive-Compulsive Disorder, Sensory Disorders
- Trial name
- SenST-Plus (NCT04335175)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Music Therapy for Pain and Sedation
Music Therapy is Associated With Decreased Pain and Agitation in Intubated ICU Patients
The study is designed to analyze the use of music therapy to decrease pain and agitation in intubated ICU patients.
- Trial name
- NCT01316536
- Testing
- provide headphones with music playing, Sounds
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, San Francisco
Schizophrenia, Schizoaffective Disorder
Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia
This study will evaluate the effectiveness of valbenazine on patient- and clinician-reported outcomes assessing health-related quality of life, functioning, and treatment effect in participants with tardive dyskinesia (TD) who…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT05859698
- Testing
- Valbenazine
- Where
- 18 sites in United States
- Volunteers
- 59 people
- Sponsor
- Neurocrine Biosciences
Primary Ciliary Dyskinesia
Utility of PCD Diagnostics to Improve Clinical Care
This is a study evaluating the utility of current Primary Ciliary Dyskinesia (PCD) diagnostic tests, including nasal nitric oxide testing.
- Trial name
- NCT03704207
- Testing
- nNO testing
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome
Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome
This study will investigate how the brain generates tics in patients with Tourette's syndrome and which areas of the brain are primarily affected.
- Trial name
- NCT00034398
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Huntington Disease
Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of MBF-015 in Huntington's Disease Patients
This is a Phase IIa (proof of concept), single center clinical trial to evaluate the safety and efficacy of daily MBF-015 oral treatment during 28 days in Huntington's Disease patients on top of standard of care.
- Trial name
- NCT06469853
- Testing
- MBF-015 16 mg oral capsules
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Medibiofarma S.L.
Parkinson s Disease, Tremor
MRgFUS for Parkinson's Tremor
This study investigates magnetic resonance-guided focused ultrasound thalamotomy (MRgFUSth) for people with Parkinson's disease (PD) and tremor not responding to conventional standard doses of dopamine replacement therapy.
- Trial name
- NCT07284719
- Testing
- MR-guided focused ultrasound thalamotomy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aarhus University Hospital
Alzheimer's Disease
Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are near-universal at some point in the…
- Trial name
- THC-AD (NCT02792257)
- Testing
- Dronabinol (Marinol®)
- Where
- 5 sites in United States
- Volunteers
- 84 people
- Sponsor
- Johns Hopkins University
Spinocerebellar Ataxias
An Open-label Trial of Intravenous Immune Globulin (IVIG)in Treating Spinocerebellar Ataxias
The purpose of this study is to learn how Intravenous Immune Globulin (IVIG) will affect Spinocerebellar Ataxia (SCA) symptoms and how it will affect motor and nervous system function in participants Subtypes of SCA to be…
- Trial name
- NCT02287064
- Testing
- Intravenous Immune Globulin (IVIG)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of South Florida
Huntington Disease
Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression
Intro Huntington's disease (HD) patients suffer from motor, cognitive and behavioral impairments, with heterogeneous phenotypes and variable time course.
- Trial name
- I2BIO-HD (NCT05808153)
- Testing
- radiotracer injection
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Ciliary Dyskinesia (PCD)
International Primary Ciliary Dyskinesia (PCD) Registry
The purpose of the international prospective PCD Patient Registry is to systematically measure, survey and compare different aspects of PCD manifestation, course and treatment, to provide data for epidemiological research and to…
- Trial name
- PCDregistry (NCT02419365)
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Muenster
Alzheimer's Disease, Agitation
Citalopram for Agitation in Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of citalopram for agitation in Alzheimer's dementia.
- Trial name
- CitAD (NCT00898807)
- Testing
- citalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- JHSPH Center for Clinical Trials
Movement Disorders, Parkinson Disease
A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling
The Infinity MRI PMCF was conducted as an international, multicenter, observational, prospective, single-arm, post-market clinical follow-up (PMCF) study.
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- NCT03884231
- Testing
- Infinity DBS System with MR Conditional labelling
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 74 people
- Sponsor
- Abbott Medical Devices
Schizophrenia Agitation, Schizo Affective Disorder
Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder
An open-label, randomized, active control inpatient trial to evaluate the efficacy and tolerability of sublingual dexmedetomidine for the treatment of agitation in inpatients with schizophrenia or bipolar disorder as measured by…
- Conditions
- Schizophrenia Agitation, Schizo Affective Disorder, Bipolar Disorder, Dexmedetomidine
- Trial name
- NCT06093451
- Testing
- Dexmedetomidine, Lorazepam 2 MG/ML
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Temple University
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