Clinical trials: Dyskinesia
Tics, Tourette Disorder
Investigating Changes in Premonitory Urges During Habit Reversal Training for Tics
The primary aim of this study is to learn more about premonitory urges (PU) when using Habit Reversal Training (HRT) to treat tics.
- Conditions
- Tics, Tourette Disorder, Tourette Syndrome in Children, Tourette Syndrome in Adolescence
- Trial name
- NCT06825520
- Testing
- Habit Reversal Training
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Utah
Parkinson's Disease
Prospective Evaluation of Forceplate Measured Levodopa-Induced Dyskinesia
Nearly all Parkinson's disease (PD) patients eventually develop abnormal and unwanted movements (dyskinesias; LID) caused by the gold standard treatment, Levodopa.
- Trial name
- NCT00912977
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Functional Movement Disorder
Virtual Reality in Functional Movement Disorder
This study investigates the effect of virtual reality (VR) motor tasks on functional movement disorders.
- Trial name
- VR-FMD (NCT06393439)
- Testing
- Virtual reality motor task
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Akathisia, Drug-Induced, Antipsychotic Agents
Study of Preladenant for the Treatment of Neuroleptic Induced Akathisia (Study P05145)
This study is designed to evaluate the effectiveness of preladenant in the prevention (Part 1) or treatment (Part 2) of antipsychotic induced akathisia in participants with acute psychosis using the Barnes Akathisia Scale.
- Conditions
- Akathisia, Drug-Induced, Antipsychotic Agents, Movement Disorders
- Trial name
- NCT00693472
- Testing
- Preladenant, Anticholinergic agents or propanolol, Haloperidol
- Volunteers
- 46 people
- Sponsor
- Merck Sharp & Dohme LLC
Hyperkinetic Movement Disorders
Compassionate Use of Tetrabenazine in the Treatment of Abnormal Movements
Although the results of studies looking at tetrabenazine have shown its effectiveness in the management of hyperkinetic(too much) movement disorders, it has not been made available in the U.S.
- Trial name
- TBZ (NCT00642057)
- Testing
- tetrabenazine
- Sponsor
- Joseph Jankovic
Parkinsonism, Tremor
TRANSPARK_LONG: The Diagnostic Value of Early Transcranial Ultrasound in Patients With Extrapyramidal Diseases in a Swedish Population
Popular science summary of the project The purpose of the study is to investigate in a Swedish population how well the investigators' previous ultrasound findings match the final diagnosis (PD, APS or ET) after a particularly…
- Conditions
- Parkinsonism, Tremor, Dementia
- Trial name
- NCT06032585
- Where
- Sweden
- Volunteers
- 74 people
- Sponsor
- Region Skane
Parkinson Disease, Essential Tremor
Cortical-Basal Ganglia Speech Networks
In this research study the researchers want to learn more about brain activity related to speech perception and production.
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia
- Trial name
- NCT04286308
- Testing
- electrophysiological data collection
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Dystonia, Dystonia; Idiopathic
Dystonia Genotype-Phenotype Correlation
The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to…
- Conditions
- Dystonia, Dystonia; Idiopathic, Dystonia, Primary, Dystonia, Secondary
- Trial name
- NCT03428009
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ataxia
Can Acute Photobiomodulation Improve Balance and Cognition in Individuals With Ataxia: a Pilot Feasibility Placebo Randomized Controlled Trial.
Cerebellar ataxias cause progressive impairments in balance, gait coordination, motor timing, and cognitive functions such as attention and executive control (Buckner, 2013; Salmi et al., 2010; Timmann \& Daum, 2007).
- Trial name
- NCT07296068
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Central Lancashire
Hereditary Ataxia, Spinocerebellar Degenerations
Telerehabilitation, Core Stability Exercises and Hereditary Ataxia (TRCore-ataxia)
Hereditary ataxias (HA) are a heterogeneous group of degenerative diseases of the cerebellum, brain stem and spinal cord. People who suffer from AH, among other symptoms, present deficiencies in the stability of the trunk, which…
- Conditions
- Hereditary Ataxia, Spinocerebellar Degenerations, Cerebellar Ataxia
- Trial name
- TRCore-ataxia (NCT06152133)
- Testing
- Therapeutic core stability exercises
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universitat de Lleida
Idiopathic Parkinson's Disease, Drug Induced Dyskinesia
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD)…
- Trial name
- TOP-DYSK (NCT01789047)
- Testing
- Topiramate, Amantadine
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Parkinson Disease, Dystonia
Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS)
The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and…
- Trial name
- NCT04707638
- Testing
- No intervention used
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Parkinson Disease
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa…
- Trial name
- NCT07432958
- Testing
- AP-472
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Appello Pharmaceuticals, Inc.
Agitation,Psychomotor
Agitation Follow up After Introduction of a New Patient Care Algorithm
Agitation in the intensive care unit is motor hyperactivity. It is frequent (b/w 30% to 70%) and has multiple causes: pain, medical reason, delirium, medication, etc.
- Trial name
- SARA (NCT04053426)
- Testing
- Implementation of agitation care algorithm
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Grenoble
Cerebellar Ataxia
Efficacy and Safety Study of Stemchymal® in Polyglutamine Spinocerebellar Ataxia
The purpose of the clinical trial is to study the therapeutic efficacy and safety of Stemchymal® infusions for polyglutamine spinocerebellar ataxia treatment by a randomized, double-blind, placebo-controlled study design.
- Trial name
- NCT02540655
- Testing
- Stemchymal®, Excipients
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Steminent Biotherapeutics Inc.
Neuroleptic-Induced Tardive Dyskinesia
Risperidone and Olanzapine for the Schizophrenic Patients With Neuroleptic-Induced Tardive Dyskinesia
We initiate a study with research grant from department of health and Taoyuan mental hospital and choose risperidone and olanzapine as study medications.
- Trial name
- NCT00621998
- Testing
- risperidone, olanzapine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
Huntington Disease
Study of Huntington Patients in Connection With European Huntington's Disease Network (EHDN)
REGISTRY is a multi-centre, multi-national, prospective, observational study of Huntington's disease (HD) with a control group of volunteers.
- Trial name
- NCT01554033
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Parkinson Disease
Effect of a Vibrating Therapy Ball on Tremor and Daily Activities in Patients With Different Tremor Syndroms
Tremors, e.g. in patients with Parkinson's disease and essential tremor, are often pharmacoresistant, meaning that invasive treatment options such as deep brain stimulation are used at an early stage.
- Trial name
- NCT07134634
- Testing
- tremor device
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Parkinson's Clinic in Beelitz-Heilstatten
Early Manifest Huntington Disease
A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease
This is the first study of branaplam in adults with Huntington's Disease (HD) to determine the correct dose required to lower mutant huntingtin protein (mHTT) levels in the cerebrospinal fluid (CSF) to a degree expected to be…
- Trial name
- VIBRANT-HD (NCT05111249)
- Testing
- Branaplam
- Where
- 12 sites in Canada, France and 3 more
- Volunteers
- 26 people
- Sponsor
- Novartis Pharmaceuticals
Primary Ciliary Dyskinesia (PCD)
A Qualitative Study Investigating the Lived Experiences and Impact of Reproductive Issues in Adults With Primary Ciliary Dyskinesia
Study involving undertaking research interviews with adults who have primary ciliary dyskinesia in the UK about their views and experiences of fertility, pregnancy and parenthood
- Trial name
- NCT07357558
- Testing
- Interview only
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
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