Clinical trials: Dyskinesia
Levodopa Induced Dyskinesia
Levetiracetam Administration for the Management of Levodopa-Induced Dyskinesias in Parkinson's Disease
Levodopa-induced dyskinesias have been associated with irregular oscillatory discharge characteristics of basal ganglia. From the other hand, LEV which shares a different electrophysiologic profile than other antiepileptics…
- Trial name
- NCT00291733
- Testing
- Levetiracetam
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- 1st Hospital of Social Security Services
Primary Ciliary Dyskinesia
Muscle Function, Exercise Capacity and Physical Activity Level in Primary Ciliary Dyskinesia and Kartagener Syndrome
Studies evaluating respiratory and peripheral muscle functions in PCD patients and comparing them with healthy children are limited in the literature.
- Trial name
- NCT05816876
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Gazi University
Tardive Dyskinesia, Tardive Dystonia
Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia
Rationale: Tardive dyskinesia and dystonia (TDD) are severe side effects of dopamine blocking agents, particularly antipsychotics.
- Trial name
- NCT02524886
- Testing
- GPi DBS with Medtronic electorde and Activa PC pulsegenerator
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- GGZ Centraal
Coordination Impairment, Children
Motor-Cognitive Training , Cognitive Performance and Balance
This RCT design investigates the effects of an 8-week motor-cognitive training program on cognitive performance and balance in preschool-aged children.
- Conditions
- Coordination Impairment, Children, Balance
- Trial name
- NCT07045922
- Testing
- Motor-Cognitive Training Program, Regular Physical education classes
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Princess Nourah Bint Abdulrahman University
Huntington Disease
Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)
Huntington's disease (HD) is a neurodegenerative pathology characterized by choreic hyperkinesias which represent the typical motor symptom and are represented by involuntary, aimless, irregular, recurrent, unpredictable and…
- Trial name
- NCT06976983
- Testing
- Portable ergonomic helmet for real tSMS
- Volunteers
- 30 people
- Sponsor
- Neuromed IRCCS
Progressive Myoclonus Epilepsy Type 1, EPM1
Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1)
The Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1) is focused on gathering longitudinal clinical data as well as biological samples (blood and/or urine) from male and female patients, of all…
- Conditions
- Progressive Myoclonus Epilepsy Type 1, EPM1, CSTB-related Disease, Myoclonus Epilepsies, Progressive
- Trial name
- EPM1 (NCT06593951)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Agitation
Liquid Risperidone in the Treatment of Acute Agitation in Psychiatrically Hospitalized Children
The goal of this study is to demonstrate safety and efficacy of liquid risperidone in psychiatrically hospitalized children, ages 4-12, who would be put in seclusion or restraint, or given an intramuscular injection of…
- Trial name
- NCT00790075
- Testing
- risperidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stony Brook University
Spinocerebellar Ataxia Type 2
Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2
Adult participants with spinocerebellar ataxia type 2 (SCA2) who carry ≥33 cytosine, adenine, guanine (CAG) repeats in the ATXN2 gene, and who have met all protocol eligibility criteria will be randomized to receive a single dose…
- Trial name
- NCT06672445
- Testing
- ARO-ATXN2 Injection
- Where
- 16 sites in Australia, Canada and 6 more
- Volunteers
- 39 people
- Sponsor
- Arrowhead Pharmaceuticals
Huntington Disease
Development of the Virtual Unified Huntington's Disease Rating Scale
The Huntington Study Group currently holds the registered trademark for the Unified Huntington's Disease Rating Scale. The UHDRS® is a research tool which has been developed by the HSG to provide a uniform assessment of the…
- Trial name
- vUHDRS (NCT05748288)
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Huntington Study Group
Huntington Disease
Cognitive Assessment Tools for Huntington's Disease.
The purpose of the current proposal is to expand understanding of two currently available cognitive tools that are not typically used in Huntington Disease (HD) clinical trials that might be useful both for initial screening and…
- Trial name
- CAT-HD (NCT06546488)
- Testing
- Assessments
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Ohio State University
Tardive Dyskinesia
Treatment of Tardive Dyskinesia With Galantamine
Tardive dyskinesia (TD), a form of movement disorder, remains a problem for some patients who received antipsychotic medications.
- Trial name
- NCT00164242
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Caroff, Stanley N., M.D.
Bradykinesia, Parkinson Disease
prTMS as an Intervention for Bradykinesia in Parkinson's Disease
This study investigates the use of patterned repetitive transcranial magnetic stimulation (prTMS) as an intervention for bradykinesia in Parkinson's Disease (PD).
- Trial name
- ADAPT-BK (NCT07397377)
- Testing
- Active patterned repetitive transcranial magnetic stimulation (prTMS)
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Alzheimer Disease, Parkinson Disease
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
The role of disorders of socio-emotional processes in cerebral diseases such as Alzheimer's disease, frontal temporal dementia, Parkinson's disease, Huntington's disease, traumatic brain injury, stroke, focal lesions, has been…
- Conditions
- Alzheimer Disease, Parkinson Disease, Frontal Dementia, Huntington Disease
- Trial name
- GREFEXII (NCT03052712)
- Testing
- social cognition
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Alzheimer's Disease, Agitation
Citalopram for Agitation in Alzheimer's Disease
The purpose of this study is to evaluate the safety and efficacy of citalopram for agitation in Alzheimer's dementia.
- Trial name
- CitAD (NCT00898807)
- Testing
- citalopram
- Where
- 8 sites in United States, Canada
- Volunteers
- 186 people
- Sponsor
- JHSPH Center for Clinical Trials
Parkinson Disease, Dyskinesias
A Follow-up of the Influencing Factors of Dyskinesia in Patients With Parkinson's Disease
Parkinson' patients who have not had dyskinesia would be observed for 2 years in a multicenter prospective study with the purposes to clarify the predicting factors of dyskinesia.
- Trial name
- PDDIFFU (NCT04453995)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Cerebellar Ataxia
Effects of High Intensity Stepping Training on Gait in Patients With Ataxia
The purpose of this study is to examine the effects of high intensity stepping training on gait recovery, including walking speed and endurance, in patients with cerebellar ataxia.
- Trial name
- NCT06450457
- Testing
- Polar H10 heart rate monitor, Therastride Treadmill System, VECTOR Bioness
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Huntington Disease
Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease
The objective of the study is to validate the use of wearable sensors and digital health technologies for monitoring disease activity in Huntington's Disease (HD).
- Trial name
- BioDigit HD-02 (NCT07315984)
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- BioSensics
Dementia, Agitation
A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD)
The purpose of this pilot is to develop a mobile application that detects physiological measures of individuals with Alzheimer's disease and related dementias and triggers auto-play of personalized songs in a wearable device.
- Conditions
- Dementia, Agitation, Depressive Symptoms
- Trial name
- NCT06140342
- Testing
- Feasibility study of music-based mobile app
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Autotune Me LLC
Essential Tremor
Responsive Deep Brain Stimulator for Essential Tremor
Essential tremor is an incurable, degenerative brain disorder that results in increasingly debilitating tremor, and afflicts an estimated 7 million people in the US.
- Trial name
- NCT02649166
- Testing
- Deep brain stimulation, Closed-loop deep brain stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Cervical Dystonia
Study of the Oral Treatment MTR-601 in Cervical Dystonia
Study MTR-601-201 is an 8-week, randomized, placebo-controlled study to examine the safety, tolerability, and efficacy of MTR-601 in participants with cervical dystonia.
- Trial name
- NCT06830642
- Testing
- MTR-601
- Where
- 17 sites in United States
- Volunteers
- 38 people
- Sponsor
- Motric Bio
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