Clinical trials: Dyskinesia
Parkinson Disease, Dystonia
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy
This is an exploratory pilot study to identify neural correlates of specific motor signs in Parkinson's disease (PD) and dystonia, using a novel totally implanted neural interface that senses brain activity as well as delivering…
- Trial name
- NCT03582891
- Testing
- Summit RC+S for Motor, 8-week pilot trial of Closed-loop vs. Open-loop Stimulation, Summit RC+S for Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Huntington Disease
Feasibility of a Video-oculography in Patients With Huntington's Disease VOG-HD Study
The purpose of this study is to know the limits of feasibility of a reliable oculomotor record for patient with Huntington's disease.
- Trial name
- VOG-HD (NCT02563418)
- Testing
- Eye-tracking
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Schizophrenia and Schizoaffective Disorder, Tardive Dyskinesia
D-Serine Treatment For Tardive Dyskinesia
Presently no generally effective treatments for tardive dyskinesia (TD) are available. D-serine is a naturally occurring amino acid that acts in-vivo as positive allosteric modulator at the glycine site associated with the…
- Trial name
- NCT01804920
- Testing
- D-serine
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Herzog Hospital
Dystonia
Efficacy and Safety of DBS in Patients With Primary Dystonia
The purpose of this study is to evaluate the safety and effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) for primary dystonia.
- Trial name
- NCT03017586
- Testing
- Beijing Pins Medical Co., Ltd. Deep Brain Stimulator
- Where
- 7 sites in China
- Volunteers
- 72 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Parkinson's Disease, Dyskinesia
Capturing Parkinson's Disease Medication Side Effects During Daily Activities
The purpose of the study is to test whether body-worn wireless motion sensors can measure dyskinesias (involuntary movements caused by medications) in individuals with Parkinson disease (PD) independent of voluntary activity…
- Trial name
- NCT01429207
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Torticollis Congenital, Motor Development
Development in Children Diagnosed With Congenital Muscular Torticollis
It has been thought that head position may affect the shoulder, rib cage and abdominal muscles, which may have a negative effect on posture control and movement development, sensory-motor coordination and cause retardation in…
- Conditions
- Torticollis Congenital, Motor Development, Sensory Integration Dysfunction
- Trial name
- NCT06879314
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gazi University
Brain Neuroimaging Biomarkers in Huntington Disease
Dynamic Neuroimaging Biomarkers in Huntington's Disease
There is no curative treatment available today in Huntington disease (HD) despite the identification of the mutated gene 20 years ago.
- Trial name
- HDeNERGY (NCT02639871)
- Where
- France
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease, Dementia, Mixed
Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS
Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems.
- Conditions
- Alzheimer Disease, Dementia, Mixed, Dementia, Behavior Problem
- Trial name
- tTED (NCT03846492)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Tardive Dyskinesia
Xenazine in Late Dyskinetic Syndrome With Neuroleptics
Late dyskinetic syndrome with neuroleptics, or tardive dyskinesia, is the appearance of abnormal involuntary movements (AIM) in patients treated with antipsychotics for at least three months.
- Trial name
- Xeladys (NCT01543321)
- Testing
- Tetrabenazine
- Where
- 19 sites in France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Agitation,Psychomotor
Olanzapine Versus Midazolam for Agitation
The goal of this research investigation is to conduct a prospective observation of the comparative efficacy of midazolam versus olanzapine for the treatment of acute undifferentiated agitation in the emergency department.
- Trial name
- OvM (NCT03899506)
- Testing
- Olanzapine, Midazolam
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Hennepin Healthcare Research Institute
Parkinson Disease
A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor)
This is a web-based study that involves monitoring hallmark symptoms of Parkinson's Disease (PD), specifically dysphonia and tremor, using smartphone sensor data.
- Trial name
- NCT04288804
- Testing
- Smartphone microphone sensor, Smartphone accelerometer sensor
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Goalspal LLC
Kidney Transplant Recipients, Old Age
Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients
The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extended-release tacrolimus…
- Trial name
- Neuro-KTR (NCT06751992)
- Testing
- Conversion to extended-release tacrolimus, Maintenance of immediate-release tacrolimus
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Friedreich's Ataxia
Biomarkers in Friedreich's Ataxia
The purpose of this project is to characterize measures of cardiac performance and neuromuscular physiology in FA patients using novel techniques, including echocardiography and magnetic resonance imaging (MRI), metabolic…
- Trial name
- NCT02497534
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Florida
Parkinson's Disease
Effects of a Dopamine Agonist on Pharmacodynamics of Levodopa in Parkinson's Disease
The purpose of this study is to determine whether there is a benefit to giving a dopamine agonist to a patient with Parkinson's disease who is already being treated with levodopa.
- Trial name
- DALI (NCT00666653)
- Testing
- pramipexole
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
Glut1 Deficiency Syndrome, De Vivo Disease
Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test
The study aims at validating the diagnostic performances of the METAglut1, a blood in vitro diagnostic test, for the simple and early diagnosis of the Glut1 deficiency syndrome (Glut1DS, or De Vivo disease).
- Conditions
- Glut1 Deficiency Syndrome, De Vivo Disease, Seizures, Movement Disorders
- Trial name
- METAglut1 (NCT03722212)
- Testing
- METAglut1
- Where
- 28 sites in France
- Volunteers
- 636 people
- Sponsor
- METAFORA biosystems
Spinocerebellar Ataxia
The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia
The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input.
- Trial name
- NCT01983631
- Testing
- Whole body vibration training
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- Chang Gung University
GNAO1, Epilepsy
Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders.
The goal of this clinical trial is to evaluate the efficacy and safety of the investigational drug ASO-GNAO1 (Tianasen) in pediatric patients with c.607G>A mutation in the GNAO1 gene associated with epilepsy and…
- Conditions
- GNAO1, Epilepsy, Hyperkinesis
- Trial name
- ASO-GNAO1 (NCT07363603)
- Testing
- Antisense oligonucleotide treatment (ASO)
- Where
- Russia
- Volunteers
- 5 people
- Sponsor
- Pirogov Russian National Research Medical University
Friedreich Ataxia
Efficacy Study of Epoetin Alfa in Friedreich Ataxia
Friedreich's ataxia (FRDA) is a rare genetic disorder characterised by severe neurological disability and cardiomyopathy. Friedreich's ataxia is the consequence of frataxin deficiency.
- Trial name
- FRIEMAX (NCT01493973)
- Testing
- Epoetin alfa
- Where
- 3 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Federico II University
Action Tremor, Stigma, Social
ET Stigma Response to Tremor Suppression
Essential Tremor (ET) is prevalent, affecting approximately 3% of the adult population. Involuntary shaking of the hands during action is a prominent feature, interfering with feeding and writing and other manual tasks.
- Trial name
- NCT07430761
- Testing
- stereotactic thalamotomy with focused ultrasound
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Texas Southwestern Medical Center
Scapular Dyskinesis
Autogenic Inhibition Versus Reciprocal Inhibition Muscle Energy Techniques Effect on Swimming Performance on Swimmers With Scapular Dyskinesis
Swimming can cause shoulder pain due to scapular dyskinesis. Proper scapula movement is necessary for efficient swimming strokes and to avoid injury.
- Trial name
- NCT06202391
- Testing
- Autogenic Inhibition-MET, Reciprocal Inhibition-MET protocol
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Foundation University Islamabad
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