Clinical trials: Dyskinesia
Neurodegenerative Diseases, Alzheimer Disease
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study
In this retrospective register study, clinically classified individuals with neurodegenerative disease from the years 2010-2021 will be verified from the clinical records from KUH and Oulu University Hospital (OUH).
- Conditions
- Neurodegenerative Diseases, Alzheimer Disease, Frontotemporal Dementia, Lewy Body Disease
- Trial name
- DEGERWD (NCT06209515)
- Where
- Finland
- Volunteers
- 61,292 people
- Sponsor
- Kuopio University Hospital
Ataxia, Chorea
Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia
Ataxia-Telangiectasia A-T is a neurodegenerative disorder of the cerebellum, manifesting with ataxia, as well as extrapyramidal features.
- Conditions
- Ataxia, Chorea, Dystonia, Parkinsonism
- Trial name
- NCT00950196
- Testing
- amantadine sulphate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Dementia, Agitation
Person- Centred Care Among Nursing Home Patients With Dementia
Dementia is a common and devastating disease in the elderly. No cure exist and there is an increasing need for care. To improve knowledge on how to provide better care for the patients with dementia in nursing homes, the…
- Trial name
- NCT01280890
- Testing
- Staff training using VIPS, Staff training using DCM, Control group
- Volunteers
- 624 people
- Sponsor
- Norwegian Centre for Ageing and Health
Tardive Dyskinesia
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
The primary objective of this study is to evaluate the efficacy of NBI-1065890 compared with placebo for the treatment of tardive dyskinesia (TD) in adult participants.
- Trial name
- NCT07365462
- Testing
- NBI-1065890
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Parkinson's Disease
BradyXplore Phase II: Bradykinesia Feature Extraction System
Study objectives are to improve motion sensor algorithms for measuring bradykinesia in the clinic and the home, evaluate test-retest reliability of motion sensor algorithms for measuring bradykinesia compared to clinician raters…
- Trial name
- NCT02358876
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Bronchiectasis Idiopathic, Cystic Fibrosis
WGS of Korean Idiopathic Bronchiectasis
Whole genome sequencing of Korean patients with idiopathic bronchiectasis and their family will perform to identify disease-causing variants.
- Conditions
- Bronchiectasis Idiopathic, Cystic Fibrosis, Primary Ciliary Dyskinesia
- Trial name
- WGS_UNK_BE (NCT03809091)
- Testing
- Whole genome sequencing
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Huntington Disease
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)
The primary goal of this study is to evaluate the long-term safety and pharmacodynamic effects of votoplam in participants with HD.
- Trial name
- NCT06254482
- Testing
- Votoplam
- Where
- 24 sites in Australia, Austria and 8 more
- Volunteers
- 144 people
- Sponsor
- Novartis Pharmaceuticals
Huntington Disease
Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease
The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.
- Trial name
- REGEN4HD (NCT07451613)
- Testing
- hNSC-01
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Leslie Thompson
Dementia, Aggression
Study of Electroconvulsive Therapy (ECT) Treatment for Agitation and Aggression in Dementia
Agitation/aggression is one of the most common and serious behavioral complications of dementia. If the behavior is refractory to standard care (behavior approaches and off label use of psychotropic medications), other evidence…
- Conditions
- Dementia, Aggression, Agitation
- Trial name
- NCT01856010
- Testing
- ECT treatment, Standard Care (Non-ECT group)
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Pine Rest Christian Mental Health Services
Parkinson's Disease
Reducing Dyskinesia in Parkinson's Disease With Omega-3 Fatty Acids
The purpose of this research study is to measure the safety (side effects) of an Omega 3 Fatty acid called docosahexanoic acid (DHA) and measure the dyskinesia (involuntary movements) in Parkinson 's disease (PD).
- Trial name
- RLID-PD (NCT01563913)
- Testing
- Docosahexaenoic Acid (DHA)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Long-Term Effects of Amantadine in Parkinsonian (AMANDYSK)
This is a French national trial, conducted using a double-blind, placebo-controlled, randomised design involving 7 centers and 80 patients of both sexes.
- Trial name
- AMANDYSK (NCT00632762)
- Testing
- mantadix
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Toulouse
Spinocerebellar Ataxia 3
Machado-Joseph Disease in Israel
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA-3) is the most common dominant ataxia. The genetic cause of this late-onset degenerative disorder is the expansion of a (CAG)n tract located in the exonic region…
- Trial name
- NCT02175290
- Where
- Israel
- Volunteers
- 250 people
- Sponsor
- Meir Medical Center
Health Volunteers, Huntington Disease
A Study to Evaluate Sigma-1 and Dopamine-2 Receptor Occupancy by Pridopidine in the Human Brain of Healthy Volunteers and in Patients With Huntington's Disease
The purpose of this study is to demonstrate engagement of pridopidine with S1R and D2R (optional) in the living human brain. No formal statistical analysis will be conducted
- Trial name
- NCT03019289
- Testing
- pridopidine (90 mg)
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Prilenia
Tremor
Intravenous Dexmedetomidine for Treatment of Shivering During Cesarean Section Under Neuraxial Anesthesia
The purpose of this study is to determine whether dexmedotomidine is effective in the treatment of shivering associated with neuraxial anesthesia during cesarean delivery.
- Trial name
- NCT02384343
- Testing
- Dexmedetomidine, Normal saline
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- St. Justine's Hospital
Huntington's Disease (HD)
Biology-Driven Cognitive Profiling in Huntington's Disease
Huntington's disease (HD) is a genetic, progressive neurodegenerative disorder characterized by early and widespread brain changes that can begin more than a decade before the onset of unequivocal motor signs.
- Trial name
- NCT07503743
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dementia
Bright Light Therapy for Individuals With Dementia
Many older adults with dementia living in long-term care facilities experience depression and agitation, which cause angst and personal suffering.
- Trial name
- NCT02800850
- Testing
- Bright Light
- Volunteers
- 71 people
- Sponsor
- Radford University
Post Stroke Scapular Dyskinesia
the Effect of Scapular Dyskinesia on the Scapular Balance Angle & Upper Extremity Sensorimotor Function in Spastic Stroke Patient. The Patients Were Diagnosed With the Lateral Scapular Slide Test, Fugl-Meyer Upper Extremity (FMUE) Scale Scores & Scapular Balance Angle Test (SBA).
to investigate the effect of Scapular dyskinesia on the scapular balance angle \& upper extremity Sensorimotor Function in spastic stroke patient.
- Trial name
- NCT04004949
- Testing
- Assessment of scapular balance angle and upper extremity sensorimotor function
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Lama Saad El-Din Mahmoud
Parkinson Disease
Dopaminergic restauratIon by intraVEntriculaire Administration
Prospective monocentric randomized controlled open-label proof-of-concept study in cross-over of two 1-month periods and a long-term follow-up period not to exceed September 30, 2023, with 2 groups: Intracerebroventricular…
- Trial name
- DIVE (NCT04332276)
- Testing
- A-dopamine, optimized oral treatment
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Lille
Huntington Disease
Prospective Huntington At Risk Observational Study
The purpose of this study is to define the natural history and experiences of people who are at risk for developing Huntington's disease but who do not know their genetic status.
- Trial name
- PHAROS (NCT00052143)
- Where
- 42 sites in United States, Canada
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Huntington Study Group
Dystonia
The Effects of Repetitive Paired Associative Stimulation in Dystonia
Background: People with dystonia have serious muscle contractions that cause abnormal movements or postures. This significantly affects their daily lives. The common type is called organic. The other type is psychogenic.
- Trial name
- NCT01888926
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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