Clinical trials: Dyskinesia
Senile Dementia, Alzheimer Type, Dementia, Alzheimer Type
A Comparison of Two Standard Therapies in the Management of Dementia With Agitation
The purpose of this study is to determine whether an antipsychotic medication alone or an antipsychotic medication in combination with divalproex is the most effective and safest way to treat agitation in elderly patients with…
- Conditions
- Senile Dementia, Alzheimer Type, Dementia, Alzheimer Type, Alzheimer Disease, Dementia
- Trial name
- NCT00208819
- Testing
- risperidone, quetiapine, olanzapine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Tremor, Essential Tremor
ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) for Treatment of Tremor
A feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Unilateral Thalamotomy in the Treatment of Tremor
- Trial name
- NCT01932463
- Testing
- ExAblate Transcranial System
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- InSightec
Tremor, Essential Tremor
Tapping Test and the Archimedean Spiral for the Differential Diagnosis of Tremor. Machine Learning Approach
In clinical practice, it is sometimes difficult to establish whether a patient's tremor is due to Parkinson's disease or essential tremor.
- Conditions
- Tremor, Essential Tremor, Parkinson Disease
- Trial name
- MATSEP (NCT06378619)
- Testing
- Tapping Test, Archimedes Spiral
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Ataxia Telangiectasia
A National Retrospective Population Based Cohort Study of the Natural History of Ataxia Telangiectasia
This is a retrospective observational study of natural-history of ataxia-telangiectasia. Understanding the natural history and its variability is not only vital to planning effective patient-centred services, and counselling…
- Trial name
- N-HAT (NCT04991701)
- Where
- 2 sites in United Kingdom
- Volunteers
- 178 people
- Sponsor
- University of Nottingham
Dyssynergia, Constipation
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients.
- Trial name
- NCT05807321
- Testing
- Fecobionics
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- The California Medical Innovations Institute, Inc.
Alzheimer's Disease
An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease
About 65% of patients with severe Alzheimer's Disease (AD) will have symptoms of agitation. There are drawbacks associated with the currently available therapeutic interventions for agitation associated with Alzheimer's Disease.
- Trial name
- NCT00097916
- Testing
- memantine HCl
- Where
- 9 sites in United States
- Volunteers
- 34 people
- Sponsor
- Forest Laboratories
Tourette Syndrome, Obsessive-Compulsive Disorder
Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder
This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what…
- Conditions
- Tourette Syndrome, Obsessive-Compulsive Disorder, Sensory Disorders
- Trial name
- SenST-Plus (NCT04335175)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Parkinson Disease, Dystonia
The Motor Network in Parkinson's Disease and Dystonia: Mechanisms of Therapy
This is an exploratory pilot study to identify neural correlates of specific motor signs in Parkinson's disease (PD) and dystonia, using a novel totally implanted neural interface that senses brain activity as well as delivering…
- Trial name
- NCT03582891
- Testing
- Summit RC+S for Motor, 8-week pilot trial of Closed-loop vs. Open-loop Stimulation, Summit RC+S for Sleep
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Francisco
Primary Ciliary Dyskinesia
Early Detection and Characterization of Primary Ciliary Dyskinesia
Primary Ciliary Dyskinesia (PCD) is a severe genetic disorder caused by various mutations in genes affecting ciliary motility. Various new and complementary diagnostic techniques, including measurements of nasal nitric oxide…
- Trial name
- NCT01070914
- Where
- Israel
- Volunteers
- 130 people
- Sponsor
- Ziv Hospital
Huntington's Disease
Follow-up Measurement of Brain PDE10A Enzyme Levels in Huntington´s Disease Gene Expansion Carriers
The aim of this study is to measure longitudinally the availability of the PDE10A enzyme in HDGECs using the radioligand [18F]MNI-659.
- Trial name
- LONGPDE10 (NCT02956148)
- Testing
- Radioligand [18F]MNI-659
- Where
- 7 sites in Denmark, Netherlands and 2 more
- Volunteers
- 45 people
- Sponsor
- CHDI Foundation, Inc.
Alzheimer Disease
Agitation and Aggressivity in Alzheimer's Disease Patients: A Cohort Study
General Hypothesis: hypothesize that A / A symptoms of AD follow a particular course, influenced by associated factors, and a prospective longitudinal observational study specifically evaluating A / A symptoms in patients with…
- Trial name
- A3C (NCT03554226)
- Testing
- NeuroPsychiatric Inventory Clinician (NPI-C)
- Where
- France
- Volunteers
- 270 people
- Sponsor
- University Hospital, Toulouse
Psychomotor Agitation, Acute Disease
IMPACT: A Study to Explore the Efficacy and Safety of Paliperidone ER in Patients With Acute Agitation
This study will investigate the effect of paliperidone ER (in combination with or without benzodiazepines) in patients presenting with symptoms of agitation and/or aggression in the context of psychosis, and will generate data…
- Trial name
- NCT01050478
- Testing
- Paliperidone ER, Benzodiazepine
- Where
- 14 sites in Belgium
- Volunteers
- 56 people
- Sponsor
- Janssen Cilag N.V./S.A.
Ataxia, Cerebellar
Efficacy of Lycra Garments in Ataxic Subjects
The aim of this study iss to analyze the effect of Lycra garments in the axial stabilization in subjects affected by ataxia, both in acquired cerebellar injuries and malformative etiology.
- Trial name
- NCT04830904
- Testing
- personalized Lycra garments
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Eugenio Medea
Latarjet, Scapular Dyskinesis
Influence of an Anterior Latarjet-type Abutment Operation on Scapular Dyskinesia and the Muscular Stabilization Mechanisms of the Scapula (DyScapLat)
The aim of this study is to assess the influence of anterior abutment surgery using the Latarjet method on the kinematics of the scapula.
- Trial name
- DyScapLat (NCT05131126)
- Testing
- Latarjet method, Different arms exercices
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Opsoclonus Myoclonus Syndrome, Neuroblastoma
Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)
The OMS/DES study is a multinational European Trial for Children with the Opsoclonus Myoclonus Syndrome / Dancing Eye Syndrome. This trial brought on the way by specialists of the EPNS (European Paediatric Neurology Society), the…
- Trial name
- NCT01868269
- Testing
- Dexamethasone acetate, dexamethasone and cyclophosphamide, dexamethasone and rituximab
- Where
- 36 sites in Austria, France and 5 more
- Volunteers
- 102 people
- Sponsor
- Institut Curie
Scapular Dyskinesis
Scapular Upward Rotation Exercises for Subjects With Deperessed Scapular Alignment
It was hypothesized that: There is no statistical significant effects of a scapular vupward rotation exercise (SURE) on scapular alignment in subjects with scapular downward rotation syndrome (SDRS).
- Trial name
- NCT04775251
- Testing
- Upward rotation exercise
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Spinocerebellar Ataxia
Wearable Gait Sensors
This research study is testing body-worn sensors to measure movement during simple tests of coordination, in order to evaluate the progression and severity of Spinocerebellar ataxia.
- Trial name
- NCT06628934
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Huntington Disease
Mass Balance Study of [14C] LPM3770164 in Healthy Participants
This is a phase 1, single-center, single-dose, open-label mass-balance study to evaluate radioactive recovery rate, radioactive PK characteristics, metabolite identification, and to observe the safety in healthy male subjects of…
- Trial name
- NCT07516899
- Testing
- [14C] LPM3770164
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Luye Pharma Group Ltd.
Muscle Spasticity, Hypertonia, Muscle
Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601.
- Conditions
- Muscle Spasticity, Hypertonia, Muscle, Cerebral Palsy, Multiple Sclerosis
- Trial name
- NCT06117020
- Testing
- MTR-601
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Motric Bio
Tardive Dyskinesia
Efficacy and Safety of NBI-98854 in Subjects With Tardive Dyskinesia
The purpose of this study is to assess the safety and efficacy of three doses (12.5, 25, and 50 mg) of NBI-98854 for the treatment of the symptoms of tardive dyskinesia (TD) in subjects with schizophrenia or schizoaffective…
- Trial name
- NCT01267188
- Testing
- NBI-98854
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Neurocrine Biosciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.