Clinical trials: Dyskinesia
Parkinson Disease
Continuous Theta Burst Stimulation as Potential Biomarker of Levodopa-induced Dyskinesias in Parkinson's Disease
The primary endpoint of the study is to identify a neurophysiological biomarker (absence of synaptic depotentiation at primary motor cortex , measured as change in the amplitude of motor evoked potentials recorded at the dorsal…
- Trial name
- NCT05795088
- Testing
- Continuous theta burst stimulation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson's Disease, Essential Tremor
Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- LFP DBS (NCT02071446)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Torticollis, Cervical Dystonia
Effects of Botulinum Toxin in Cervical Dystonia
Botulinum toxin injection in the contracting muscles has proven to be a safe and effective method of relieving pain and lessening dystonic posturing.
- Trial name
- NCT01056861
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Agitation
Dexmedetomidine Transdermal Systems (DMTS) Treatment for Agitation Associated With Dementia of the Alzheimer's Type
The primary objective of this study is to evaluate the efficacy of DMTS on frequency and severity of agitation associated with dementia of the Alzheimer's type, compared with placebo.
- Trial name
- NCT06052254
- Testing
- 12 cm2 - 2 Active DMTS Patches
- Where
- 8 sites in United States
- Volunteers
- 150 people
- Sponsor
- Teikoku Pharma USA, Inc.
Constipation, Chronic Constipation
Balloon Inflation in Biofeedback
Chronic constipation, particularly due to dyssynergic defecation, is common and impacts quality of life. Biofeedback therapy (BFT) is the most effective conservative treatment, teaching patients to coordinate abdominal and anal…
- Conditions
- Constipation, Chronic Constipation, Dyssynergia, Anismus
- Trial name
- NCT07705542
- Testing
- Inflating anorectal catheter balloon to defecatory desired volume during push manoeuvres in biofeedback therapy., No intervention
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Neuropathy, Cerebellar Ataxia
Evaluation of the Peripheral Nerve Ultrasound as a Diagnostic Tool in CANVAS Neuropathies
Cerebellar ataxia with neuropathy and bilateral areflexia syndrome (CANVAS) is a late onset neurodegenerative disorder with a slowly progressive ataxia.
- Conditions
- Neuropathy, Cerebellar Ataxia, Neurodegenerative Diseases
- Trial name
- CANVAS (NCT05095870)
- Testing
- No intervention
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dystonia, Focal Hand Dystonia
Transcranial Electrical Polarization to Treat Focal Hand Dystonia
This study will evaluate the effect of transcranial electrical polarization (TEP), also called direct current (DC) stimulation, on focal hand dystonia in people with writer's cramp.
- Conditions
- Dystonia, Focal Hand Dystonia, FHD
- Trial name
- NCT00106782
- Testing
- Transcranial Electrical Polarization (TEP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alzheimer Disease
Agitation in Alzheimer's Disease
Agitation affects 70 to 90 percent of patients with AD. Signs of agitation include verbal and physical aggressiveness, irritability, wandering, and restlessness.
- Trial name
- NCT00000179
- Testing
- Trazodone, Haloperidol
- Where
- 16 sites in United States
- Sponsor
- National Institute on Aging (NIA)
Agitation
Quality Improving Program on Agitation in the Surgical Intensive Care Unit
Agitation in the intensive care unit can have multiple consequences. The investigators hypothesize that agitation and its consequences can be reduced by the introduction of a reminder aiming at guiding the management of…
- Trial name
- NCT02199262
- Testing
- music intervention, reflexology, reminder
- Where
- Switzerland
- Volunteers
- 1,107 people
- Sponsor
- University Hospital, Geneva
Dementia, Alzheimer's Disease
Collaboration Between Department of Old Age Psychiatry and Nursing Homes
Dementia is a serious health problem showing an increasing prevalence rate with increasing age. In Norway, about 80% of nursing home patients have dementia. The mean age of nursing home residents in Norway is around 84 years.
- Conditions
- Dementia, Alzheimer's Disease, Behavioral Symptoms, Agitation
- Trial name
- SAM-AKS (NCT01217541)
- Testing
- Education and Supervision, Control
- Where
- Norway
- Volunteers
- 700 people
- Sponsor
- Sykehuset Innlandet HF
Essential Tremor, Tremor
Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response
Essential Tremor (ET) is the most common tremor disorder, currently affecting an estimated 2.9 million Americans and leading to disability and decreased quality of life in 75% of cases.
- Trial name
- NCT02495883
- Testing
- Ethanol, Propranolol
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Dementia
Effect of "breath of Fresh Air" Flash Activity on Dementia Agitation : Pilot Study
Non-drug therapies (NDT) constitute a strong axis of the person with dementia behaviour management. Among these NDT, the flash activities constitute a mode of intervention to prevent and control the expression of the most…
- Trial name
- DEMACTIFLASH (NCT04094779)
- Testing
- Usual relation care, Flash activity "breath of fresh air"
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Toulouse
Ataxia, Cerebrovascular Accident
PET Scan to Study Brain Control of Human Movement
Positron Emission Tomography (PET) is a technique used to investigate activity in areas of the brain. The PET technique allows researchers to study the normal processes in the brain (central nervous system) of normal individuals…
- Conditions
- Ataxia, Cerebrovascular Accident, Healthy, Movement Disorder
- Trial name
- NCT00001324
- Where
- United States
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tics, Functional Tics
Distinguishing Tics and Functional Tics Using Clinical Neurophysiological Techniques
Background: Tics are involuntary movements and vocalizations. Some tics are organic: They are related to diagnosed disorders. Sometimes tics have other causes, such as problems with how the brain and body send and receive…
- Trial name
- NCT07137442
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Essential Tremor
A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.
The purpose of this study is to assess the safety and effectiveness of topiramate as compared to placebo in treating patients with tremor of unknown cause.
- Trial name
- NCT00236496
- Testing
- topiramate
- Volunteers
- 223 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Parkinson's Disease
Reducing Dyskinesia in Parkinson's Disease With Omega-3 Fatty Acids
The purpose of this research study is to measure the safety (side effects) of an Omega 3 Fatty acid called docosahexanoic acid (DHA) and measure the dyskinesia (involuntary movements) in Parkinson 's disease (PD).
- Trial name
- RLID-PD (NCT01563913)
- Testing
- Docosahexaenoic Acid (DHA)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Tourette Syndrome
Open-Trial of EPI-743 for Adults With Tourette Syndrome
The purpose of this study is to examine the effects of EPI-743 on tic severity in adults with Tourette syndrome.
- Trial name
- NCT01719523
- Testing
- EPI-743
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Spinocerebellar Atrophy (SCA)
The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria
In individuals with spino-cerebellar atrophy (SCA), the delayed onset of antagonist muscle firing has been reported to be the cause of hypermetria.
- Trial name
- NCT01983670
- Testing
- Temporal electrical stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Delirium, Agitation
The Effectiveness of Acupuncture for Complications in Critically Ill Patients
Introduction: Intensive care unit (ICU) is a special department in the health care facility. Although with high development of modern medicine nowadays, the average mortality rate in ICU is still around 7 to 20 %.
- Conditions
- Delirium, Agitation, Arrhythmia, Feeding Intolerance
- Trial name
- NCT04950738
- Testing
- pess tack acupuncture
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Huntington Disease
Pridopidine Phase 3 Study in Huntington's Disease
The goal of this clinical trial is to learn if pridopidine can slow the clinical decline of Huntington's Disease (HD) in adult participants. It will also inform about the safety of pridopidine.
- Trial name
- PRECISE-HD (NCT07609108)
- Testing
- Pridopidine
- Where
- 66 sites in United States, Belgium and 10 more
- Volunteers
- 400 people
- Sponsor
- Prilenia
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