Clinical trials: Dyslipidemias
Cardiovascular Risk Factor, Lipemia
Effect of Galactose Ingestion on Postprandial Lipemia
This study aims to assess the postprandial triglyceride response to the ingestion of a high-fat meal with co-ingestion of either galactose, or glucose.
- Trial name
- NCT03439878
- Testing
- Galactose, Glucose
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Bath
Hypercholesterolemia
Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)
Participants currently taking atorvastatin 20 mg will be switched to either atorvastatin 40 mg or ezetimibe/simvastatin 10 mg/40 mg (10/40).
- Trial name
- NCT00782184
- Testing
- ezetimibe/simvastatin 10/40, atorvastatin 40 mg, atorvastatin 20 mg
- Volunteers
- 250 people
- Sponsor
- Organon and Co
Dyslipidemia
A Study to Assess the Efficacy and Safety of ETC-1002 in Subjects With Elevated Blood Cholesterol and Either Normal or Elevated Triglycerides
This Phase 2 proof-of-concept study will assess the lipid regulating efficacy and safety of ETC-1002 in subjects with hypercholesterolemia and either normal or elevated triglycerides.
- Trial name
- NCT01262638
- Testing
- ETC-1002
- Where
- 11 sites in United States
- Volunteers
- 177 people
- Sponsor
- Esperion Therapeutics, Inc.
Hyperlipidemia
Effect of Different Types of Carbohydrates Consumed After Exercise on Blood Fat Levels
The increase in fat (i.e. triglyceride) in the blood after a meal is a well-established risk factor for heart disease (Nordestgaard et al. 2007).
- Trial name
- NCT02012855
- Testing
- Exercise, Diet (meal type)
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis
GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis
Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is associated with a high risk of recurrence despite standard lipid-lowering therapy and lifestyle modification.
- Conditions
- Hypertriglyceridemia Induced Acute Pancreatitis, Recurrent Acute Pancreatitis, Pancreatitis Relapsing, Hypertriglyceridemia
- Trial name
- RECAP-GLP1 (NCT07617155)
- Testing
- Semaglutide
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Peking Union Medical College Hospital
Hypercholesterolemia
Artichoke and Bergamot Phytosome
According to WHO data, about 50% of deaths each year are caused by cardiovascular disease. One of the strategies for prevention of cardiovascular diseases, in addition to a correct lifestyle, is to implement therapies that reduce…
- Trial name
- NCT04697121
- Testing
- Combined Bergamot phytosome and Artichoke leaf dry extract
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Kidney Transplant; Complications
Modification of Diet in Renal Transplantation (MDRT)
Abnormalities in lipid metabolism are present in 50-80% of patients with a kidney transplant and together with concurrent comorbidities and other associated cardiovascular risk factors put kidney transplant recipients at a…
- Trial name
- MDRT (NCT03612778)
- Testing
- Plant-based diet, Mediterranean diet
- Where
- Slovenia
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Hypercholesterolemia
The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults.
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries. Results from several epidemiological and clinical studies indicate a positive correlation between elevated total serum…
- Trial name
- ProLoChol (NCT03540108)
- Testing
- Lactobacillus plantarum ECGC 13110402
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Roehampton
Cardiovascular Diseases, Hypertension
Church-based Health Intervention to Eliminate Racial Inequalities in Cardiovascular Health
Cardiovascular disease (CVD) is the leading cause of death in the US general population. Although CVD mortality rates declined for both Black and White populations during the past two decades, they are still higher in Black…
- Conditions
- Cardiovascular Diseases, Hypertension, Diabetes, Hypercholesterolemia
- Trial name
- CHERISH (NCT06065098)
- Testing
- Evidence-based interventions recommended by the 2019 ACC/AHA Guideline on the Primary Prevention of CVD
- Where
- United States
- Volunteers
- 812 people
- Sponsor
- Tulane University
Dyslipidemia, Diabetes
Crestor RAPID (The Efficacy of RosuvAstatin for Korean Dyslipidemia PatIents With Diabetes)
To evaluate the efficacy of rosuvastatin in Korean dyslipidemia patients with diabetes
- Trial name
- RAPID (NCT00526552)
- Where
- 3 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- AstraZeneca
Diabetes, Hyperlipidemias
The PK Characteristics of the Co-administration of Metformin SR and Rosuvastatin and JLP-1310 in Healthy Male Volunteers.
A randomized, open-label, single dose, crossover study to compare the pharmacokinetic characteristics of the co-administration of metformin SR and rosuvastatin and JLP-1310 in healthy male volunteers.
- Trial name
- NCT03690778
- Testing
- "Metformin" and "Rosuvastatin" seperately, JLP-1310
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Jeil Pharmaceutical Co., Ltd.
Hypertriglyceridemia, Acute Pancreatitis
Insulin and Standard Management in Hypertriglyceridemic Acute Pancreatitis
To compare the efficacy of infusion containing insulin and infusion without insulin on reduction of triglycerides in acute hypertriglyceridemic pancreatitis
- Trial name
- NCT05487833
- Testing
- insulin, standard treatment
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Hypercholesteremia
Observational to Investigate the Efficacy of CRESTOR 5mg in Reaching LDL-C Target Goals in Patients Who Are at High Risk for a Cardiovascular Event
Observational study to investigate the use and efficacy of CRESTOR 5 mg in reaching LDL-C target goals in both statin naïve and statin treated primary and secondary prevention patients at high risk for a cardiovascular event.
- Trial name
- NCT00347217
- Where
- 215 sites in Netherlands
- Volunteers
- 3,840 people
- Sponsor
- AstraZeneca
Hypertension and Dyslipidemia
A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386(3) 80/20/10mg
A Clinical Trial to evaluate the Pharmacokinetics and Tolerability of CKD-386(3)
- Trial name
- NCT05245084
- Testing
- CKD-386(3), D013, D326, D337
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Obstructive Sleep Apnea
Effect of CPAP on Biomarkers in Patients With OSA
CPAP, the standard treatment for Obstructive sleep apnea syndrome (OSAS) that reduces sleep fragmentations and neurocognitive deficit in OSAS may also have a key role in reduction of cardiovascular, mortality risks in the same…
- Trial name
- CPAP (NCT01138865)
- Testing
- AutoSet Spirit--Wash--Modified-AutoSet Spirit, Modified-AutoSet Spirit--Wash-AutoSet Spirit
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Hypercholesterolemia
Role of A2A Receptor in Hypercholesterolemic Patients
Hypercholesterolemia promotes chronic inflammation, endothelial dysfunction, atherosclerosis and is a major risk factor for cardiovascular disease (CVD).
- Trial name
- RASCAS (NCT05017649)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Healthy Participants, Hyperlipidemia
A Phase 1 Study of VELA-101 in Adult Participants
This is a first-in-human (FIH), multicenter, randomized, double-blind, placebo-controlled study evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VELA-101, following single-ascending doses…
- Trial name
- NCT07864311
- Testing
- VELA-101
- Where
- 2 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ursa Medicines
Stroke, Hypertension
DELPHI in Subjects at Risk for Stroke and Dementia
The DELPhi system is a software device that is used for the noninvasive evaluation of brain plasticity and connectivity. The DELPhi software uses EEG and TMS devices as accessories.
- Conditions
- Stroke, Hypertension, Diabete Mellitus, Dyslipidemias
- Trial name
- NCT03884647
- Testing
- DELPhI system
- Where
- 4 sites in United States, Israel
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- QuantalX Neuroscience
Hyperlipemia
Safety and Tolerability of SHR-1918 in Healthy Subjects
The primary objective of this study is to assess the safety and tolerability of SHR-1918 injection in healthy subjects. In addition, this study will provide information on pharmacokinetics and pharmacodynamics of SHR-1918…
- Trial name
- NCT05432544
- Testing
- SHR-1918
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beijing Suncadia Pharmaceuticals Co., Ltd
Lipodystrophy, Diabetes
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
Background: Generalized lipodystrophy can cause high blood fat levels and resistance to insulin. This can lead to health problems including diabetes.
- Conditions
- Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT02262832
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)