Clinical trials: Dyslipidemias, open to volunteers
Homozygous Familial Hypercholesterolemia
Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia
This study will evaluate the efficacy and safety of zodasiran subcutaneous (sc) injection in participants 12 to <18 years of age with genetically or clinically diagnosed homozygous familial hypercholesterolemia (HoFH) and…
- Trial name
- SPRUCE (NCT07473843)
- Testing
- Zodasiran
- Where
- 3 sites in United States, Denmark and 1 more
- Volunteers
- 10 people
- Sponsor
- Arrowhead Pharmaceuticals
Heterozygous Familial Hypercholesterolemia (HeFH)
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
A phase 1/2, two-part trial consisting of an open label dose-escalation part and a randomized, double blind, placebo-controlled part to investigate safety, tolerability, pharmacokinetics, and efficacy with EDIT-401 gene editing…
- Trial name
- NCT07894887
- Testing
- Drug: EDIT-401
- Where
- 2 sites in Australia
- Volunteers
- 56 people
- Sponsor
- Editas Medicine, Inc.
Acute Myocardial Infarction, Dyslipidemias
Ezetimibe Utilization Early After Acute Myocardial Infarction, "EzAMI Trial"
Rationale: Patients with acute coronary syndromes are at an increased risk for recurrent adverse coronary events, particularly during the early period following their initial presentation.
- Trial name
- EzAMI (NCT04701242)
- Testing
- Ezetimibe 10mg
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Cairo University
Obesity & Overweight, Diabetes Mellitus, Type 2
Chinese Overweight/Obesity Cohort: Metabolic & Comorbidity Risks
This is a nationwide, multi-center, long-term follow-up study of overweight and obese adults in China. The study aims to recruit approximately 26,000 participants across 39 hospitals to better understand how body weight affects…
- Conditions
- Obesity & Overweight, Diabetes Mellitus, Type 2, Hypertension, Non-alcoholic Fatty Liver Disease (MASLD)
- Trial name
- NCT07884903
- Testing
- No intervention; observational assessment only
- Where
- China
- Volunteers
- 25,974 people
- Sponsor
- Shanxi Bethune Hospital
Epilepsy, Dyslipidemia
Improving Cardiovascular Health Risks in Adults With Epilepsy on a Modified Atkins Diet
Ketogenic diet therapies (KDTs) emphasize high fat and very low carbohydrate intake and help to control seizures in adults who fail to respond to medications.
- Trial name
- NCT06369571
- Testing
- Atorvastatin 10mg, Modification of dietary fat composition
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Johns Hopkins University
Primary Hypercholesterolaemia, Mixed Dyslipidemia
A Study of Bempedoic Acid or Its Single-pill Combination Therapy With Ezetimibe in Patients With Primary Hypercholesterolaemia or Mixed Dyslipidaemia
There is limited efficacy and safety data of bempedoic acid or its fixed dose combination (FDC) with ezetimibe in Asian and Latin American patients.
- Trial name
- Musashi (NCT07206472)
- Testing
- Combination of bempedoic acid and ezetimibe
- Where
- 38 sites in Brazil, Hong Kong and 1 more
- Volunteers
- 2,120 people
- Sponsor
- Daiichi Sankyo
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hypertension, Dyslipidemia
A Novel Digital Tool Clinicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors
The investigators will conduct a feasibility and pilot efficacy randomized controlled trial to test the usability and user satisfaction of an evidence-based digital health tool the investigators developed for clinicians to use to…
- Conditions
- Hypertension, Dyslipidemia, Diabetes Mellitus, Obesity
- Trial name
- P3-EX (NCT07238556)
- Testing
- Experimental - 12 Week P3-EX Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants, Active Control - 12 Week ACSM-PAVS Unsupervised Exercise Program with Virtual Weekly Oversight from Graduate Research Assistants
- Where
- 3 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Connecticut
Hypertension (HTN), Diabetes
Evaluation of a New Virtual Care Pathway for Older Adults With Noncommunicable Diseases
The purpose of this study is to evaluate a newly developed virtual care program for older adults with chronic diseases (hypertension, diabetes and lipid disorders) whether it is feasible and economical to implement in the…
- Conditions
- Hypertension (HTN), Diabetes, Dyslipidaemia
- Trial name
- TeleCOOP-NCD (NCT07843238)
- Testing
- Teleconsultation care pathway for older adults with NCDs (TeleCOOP-NCD©)
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- National University of Malaysia
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia (NADI-MyHeartRisk)
This is a pragmatic, risk-stratified, individually randomized controlled trial testing whether personalised WhatsApp-based digital behavioural nudges can improve completion of cardiovascular preventive actions after community…
- Trial name
- NADI-MHR (NCT07879144)
- Testing
- Personalised Digital Behavioural Nudges (NADI-MyHeartRisk Enhanced Pathway)
- Where
- 2 sites in Malaysia
- Volunteers
- 6,588 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Advancement and Research Excellence Institute
Atherosclerotic Cardiovascular Disease (ASCVD), Hypertension
Evaluation of an Integrated, Digital, Nurse-led, Remote Monitoring Care Pathway for Cardiovascular Risk Management
The goal of this observational study is to evaluate the implementation of a structured, digital, nurse-led, remote monitoring care pathway for cardiovascular risk management (CVRM).
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Hypertension, Dyslipidemia
- Trial name
- TELE-CVRM (NCT07208331)
- Where
- Netherlands
- Volunteers
- 750 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Disease, Chronic Disease Management
Taining Golden Lake Comprehensive Chronic Disease Management Initiative
This study aims to establish the first county-level, population-based prospective cohort in Taining County, Fujian Province, China. The cohort will include at least 20,000 residents aged 18 years or older.
- Conditions
- Chronic Disease, Chronic Disease Management, Hypertension, Diabetes Mellitus
- Trial name
- TAIGOLD-CDM (NCT07308314)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Coronary Atherosclerosis, Mixed Dyslipidemia
A Study of Bempedoic Acid/Ezetimibe/High-intensity Statin in Patients Without Cardiovascular Events
The overall objective of the trial is to evaluate the effect of the triple therapy consisting of bempedoic acid (BA), ezetimibe (EZE), and high-intensity atorvastatin or rosuvastatin on changes in coronary plaque burden and…
- Conditions
- Coronary Atherosclerosis, Mixed Dyslipidemia, Hypercholesterolemia
- Trial name
- NCT07474649
- Testing
- Bempedoic acid, Ezetimibe, Rosuvastatin
- Where
- 12 sites in Germany, Italy and 1 more
- Volunteers
- 103 people
- Sponsor
- Daiichi Sankyo
Myocardial Infarction (MI), Dyslipidemias
Germany on Target Registry
Germany on Target Registry (DaZiR) is a prospective, Germany-wide patient registry designed to assess lipid management and low-density lipoprotein cholesterol ( LDL-C) target attainment in adults following acute myocardial…
- Trial name
- DaZiR (NCT07835282)
- Testing
- No study-assigned intervention
- Volunteers
- 10,000 people
- Sponsor
- Deutsche Gesellschaft für Lipidologie e. V. (DGFL) - Lipid-Liga
Hypertension, Stroke
A Cluster-Randomized Controlled Trial
The goal of this study is to learn if an AI-generated personalized health report combined with face-to-face guidance from cardiologists can help rural adults with high blood pressure control their blood pressure better and reduce…
- Conditions
- Hypertension, Stroke, Cardiovascular, Coronary Heart Disease
- Trial name
- NCT07845448
- Testing
- AI-powered personalized health report with cardiologist consultation and prescription optimization, Integrated management (follow-up, education, quality control) without AI report and cardiologist consultation
- Volunteers
- 14,400 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Cardiovascular, Metabolic Disease
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
This is a single-arm, open-label, multicenter, ascending dose Phase 1 trial that will enroll participants 18 to 75 years of age with dyslipidemias that are refractory to available treatments.
- Conditions
- Cardiovascular, Metabolic Disease, Dyslipidemias, Lipid Disorder
- Trial name
- NCT07491172
- Testing
- CTX310
- Where
- 17 sites in United States, Australia and 2 more
- Volunteers
- 90 people
- Sponsor
- CRISPR Therapeutics AG
Acute Coronary Syndromes, Dyslipidemia
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome
This randomized clinical trial will evaluate whether starting bempedoic acid in addition to high-intensity statin therapy and ezetimibe within 72 hours after percutaneous coronary intervention improves low-density lipoprotein…
- Trial name
- EARLY-BIRD ACS (NCT07824323)
- Testing
- bempedoic acid, Ezetimibe, High-Intensity Statin Therapy
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Medical University Hospital
Hypertension, Dyslipidemia
Polypills Approach for Multiple Cardiovascular Risk Factors
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated…
- Conditions
- Hypertension, Dyslipidemia, Diabetes
- Trial name
- PACIF (NCT07679828)
- Testing
- Fixed-Dose Combination Strategy
- Where
- 15 sites in China
- Volunteers
- 8,252 people
- Sponsor
- China Medical University, China
Osteoarthritis Pain, Myocardial Infarction (MI)
Community Physical Exercise Program in Chronic Disease
This study focuses on promoting physical activity (PA) through the implementation of a Community Physical Exercise Program for Chronic Diseases (CPEP-CD), targeting individuals aged 50 years and older with at least two of the…
- Conditions
- Osteoarthritis Pain, Myocardial Infarction (MI), Hypertension, Dyslipidemia
- Trial name
- CPEPCD (NCT06771024)
- Testing
- Physical Exercise
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv
Dyslipidemias
Phase 2 Trial Evaluating the Efficacy and Safety of RBD5044 in Patients With Mixed Dyslipidemia
The goal of this clinical trial is to learn if drug RBD5044 works to treat mixed dyslipidemia in adults. It will also learn about the safety of drug RBD5044.
- Trial name
- NCT06797401
- Testing
- RBD5044
- Where
- 4 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Ribocure Pharmaceuticals AB