Clinical trials: Dysmotility
Trochlear Nerve Palsy
Effects of Ocular Electroacupuncture on Trochlear Nerve Palsy
The purpose of the study is to testify the efficacy of treating trochlear nerve palsy with ocular electroacupuncture or ocular acupuncture, and to compare the efficacy between these two interventions.
- Trial name
- NCT03099473
- Testing
- ocular electroacupuncture, ocular acupuncture
- Where
- China
- Volunteers
- 144 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gastrointestinal System Disease, Functional Bloating
Short-term Effect of Exercise and Self-manual Approaches to Bloating - Distention
Abdominal bloating and distension (ABD) are the most commonly gastrointestinal symptoms reported by patients with various functional gut disorders such as functional dyspepsia, irritable bowel syndrome and it is frequently…
- Conditions
- Gastrointestinal System Disease, Functional Bloating, Distension; Bowel, Gastrointestinal Motility Disorder
- Trial name
- NCT06347367
- Testing
- Group 1 (exercise and self-manual approaches targeting only the diaphragm muscles), Group 2 (exercise and self-manual approaches targeting both diaphragm and core muscles)
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ege University
Functional Dyspepsia
Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional Dyspepsia
The study is conducted in patients with functional dyspepsia or chronic gastritis. The purpose of this study is to: assess whether the dose of Itopride Hydrochloride 150 mg extended release tablets, taken once daily has a similar…
- Trial name
- NCT06217393
- Testing
- Itopride Hydrochloride 150 mg extended release tablets, Itopride Hydrochloride 50 mg film coated tablets
- Where
- 19 sites in Armenia, Malaysia and 3 more
- Volunteers
- 564 people
- Sponsor
- Abbott
Gastrointestinal Dysmotility
Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function
Post-operative administration of ipamorelin is expected to reduce time to recovery of Gastrointestinal (GI) function in patients who have undergone partial small and/or large bowel resection.
- Trial name
- NCT01280344
- Testing
- Saline Solution for Injection, Ipamorelin
- Where
- 45 sites in United States
- Volunteers
- 320 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Non-Cardiac Chest Pain
The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients
Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease.
- Trial name
- NCT00164814
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Covid19, Motility Disorder
Coordination and Locomotor Problems in Patients With Covid-19 Virus
Coordination and Locomotor Problems in Patients With Covid-19 Virus
- Conditions
- Covid19, Motility Disorder, Balance
- Trial name
- NCT04734717
- Testing
- Neurology test
- Where
- Hungary
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Healthy Volunteers
Intestinal Dysmotility: Effect of Colonic Load
Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic distension, and it is not clear whether these abnormalities reflect a primary jejunal dysfunction or are due to a reflex distortion.
- Trial name
- NCT05046743
- Testing
- Colonic gas load
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Esophageal Diseases, Achalasia
PRospective Registry of Esophageal Motility
Digestive physiopathology is a branch of gastroenterology aiming to study patients with upper GI symptoms, mainly gastro-esophageal, potentially indicating the presence of Gastroesophageal Reflux Disease (GERD)/Barrett Esophagus…
- Conditions
- Esophageal Diseases, Achalasia, Eosinophilic Esophagitis, Motility Disorder
- Trial name
- PREM (NCT07506746)
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Gastrointestinal Dysmotility
Ulimorelin Study of Efficacy and Safety (ULISES 007)
Post-operative administration of ulimorelin is expected to reduce time to recovery of Gastrointestinal (GI) function in patients who have undergone partial large bowel resection.
- Trial name
- ULISES (NCT01285570)
- Testing
- Ulimorelin Intravenously (IV), 5% dextrose in water
- Where
- 45 sites in United States, Hungary and 5 more
- Volunteers
- 332 people
- Sponsor
- Tranzyme, Inc.
Postoperative Passage of Flatus, Postoperative Bowel Movement
Reduction of Postoperative Gastrointestinal Dysmotility Following Total Laparoscopic Hysterectomy.
Return of bowel function is an integral component of postoperative recovery following minimally invasive gynecologic surgery. To date, there is no standardized regimen to optimize bowel motility postoperatively.
- Trial name
- NCT03800745
- Testing
- Colace 100Mg Capsule, Miralax
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Gastroparesis, Slow Transit Constipation
Comparison of the Atmo Motility Gas Capsule System to the Reference Standard
The study objective is to demonstrate the equivalence of the Atmo Motility Gas Capsule System with the predicate SmartPill in measuring gastric emptying time and colonic transit time through examination of device agreement.
- Conditions
- Gastroparesis, Slow Transit Constipation, IBS
- Trial name
- NCT05718505
- Testing
- Atmo Motility Gas Capsule System, SmartPill Monitoring System
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Atmo Biosciences Pty Ltd
Diabetic Gastroparesis
Correlation Between Advanced Glycation End Products and Gastric Motility Disorder in Diabetes Gastroparesis
This study is a prospective observational study. The study will explore the correlation between advanced glycation end products and gastric motility disorder in diabetic gastroparesis（DGP) through the collection of blood and…
- Trial name
- NCT07324785
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Northern Jiangsu People's Hospital
Autoimmune Gastrointestinal Dysmotility
Novel Antineuronal Antibodies in Gastrointestinal Motility Disorders
Gastrointestinal motility disorders represent a heterogeneous group of neuromuscular diseases of the enteric nervous systems. While autoimmune neuromuscular diseases of the central nervous system (CNS) are well described, the…
- Trial name
- NCT04872439
- Testing
- Blood sample collection
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Dysmotility Syndrome, Autoimmunity
Autoimmune Gastrointestinal Dysmotility: Symptoms, Pathogenesis and Treatment
Autoimmune gastrointestinal dysmotility syndromes are poorly understood, and often difficult to treat because the underlying pathogenesis is unclear. Refractory symptoms result in an impaired quality of life.
- Trial name
- NCT04859829
- Testing
- Current Intravenous Immunoglobulin (IVIG) treatment, No Intravenous Immunoglobulin (IVIG) treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Mitochondrial Diseases
Low Residue Diet Study in Mitochondrial Disease
Slow movement of patients guts is referred to as intestinal dysmotility, and is increasingly recognised as a debilitating manifestation of mitochondrial disease both in adults and children.
- Trial name
- LRD (NCT03388528)
- Testing
- Low Residue Diet Intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Newcastle University
Oesophageal Motility Disorder
Correlation Between Clinical Signs and High-resolution Manometry Data in Children
High resolution oesophageal manometry (HRM) is the gold standard for the diagnosis of oesophageal motility disorder. Standard esophageal manometry has been replaced since 2000 by high resolution manometry.
- Trial name
- NCT03662490
- Testing
- High resolution oesophageal manometry
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Abdominal Surgery
Electroacupuncture for Gastrointestinal Dysmotility After Abdominal Surgery
In Taiwan, the number of patients who underwent abdominal surgery that attributed to gastrointestinal diseases, gynecological diseases, and cancer is increasing.
- Trial name
- NCT04467528
- Testing
- Electroacupuncture, Conventional drug therapy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- China Medical University Hospital
Upper Gastrointestinal Motility Disorders
Use of an Ambulatory Capsule to Characterize Gastrointestinal Pressure Patterns in Children
This study will test a new medical device called the SmartPill GI Monitoring System, which is now used to diagnose gastric motility disorders in adults, in children.
- Trial name
- NCT01026922
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nationwide Children's Hospital
Gastrointestinal Dysmotility
Ulimorelin Study of Efficacy and Safety (ULISES 008)
Post-operative administration of ulimorelin is expected to reduce time to recovery of Gastrointestinal (GI) function in patients who have undergone partial large bowel resection
- Trial name
- NCT01296620
- Testing
- Ulimorelin Intravenously (IV), Ulimorelin Invtravenously (IV), 5% dextrose in water
- Where
- 50 sites in United States, Bulgaria and 4 more
- Volunteers
- 330 people
- Sponsor
- Tranzyme, Inc.