Clinical trials: Dyspareunia
Provoked Vestibulodynia
Integrated Mindfulness for Provoked Vestibulodynia
This study aims to test the efficacy of a 4-session intervention (Group psychoeducational treatment) using a randomized study design. Participants will be randomized in to 'immediate treatment' or 'waitlist control'.
- Trial name
- IMPROVED (NCT01704443)
- Testing
- Group Psychoeducational Treatment, Waitlist control
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- University of British Columbia
Genitourinary Abnormality, Breast Cancer Female
GSM (Genitourinary Syndrome Of Menopause) Management In Breast Cancer Survivors
The impact of treatment for GSM on the quality of life will be examined for postmenopausal women (defined as last menstrual period > 1 year ago or 6 months ago with FSH >40) who have been diagnosed with breast cancer.
- Conditions
- Genitourinary Abnormality, Breast Cancer Female, Vaginal Abnormality, Urinary Tract Infections
- Trial name
- GSM (NCT03185169)
- Testing
- Replens and coconut oil
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Alta Bates Summit Medical Center
Menopause, Genitourinary Syndrome of Menopause
Effectiveness of a Telerehabilitation Program for Improving Sexual Function and Reducing Pain in Menopausal Women
The aim of this study is to analyze the effectiveness of a telerehabilitation program with respect to a face-to-face physiotherapy protocol in relation to the improvement of sexual function, the reduction of pain and the…
- Conditions
- Menopause, Genitourinary Syndrome of Menopause, Dyspareunia
- Trial name
- NCT06710002
- Testing
- Pelvify: Menopause and dyspareunia treatment, Face to Face Physical Therapy Protocol, Face to Face Protocol Combined With an Asynchronous Telerehabilitation Program
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Instituto Médico Tecnológico SL
Genitourinary Syndrome of Menopause, Vaginal Atrophy
Vaginal Laser Therapy in Breast Cancer Survivors
This study evaluates the efficacy of vaginal CO2 laser therapy in breast cancer survivors with symptoms of Genitourinary Syndrome of Menopause.
- Conditions
- Genitourinary Syndrome of Menopause, Vaginal Atrophy, Breast Cancer, Dyspareunia
- Trial name
- NCT03738605
- Testing
- Microablative Fractional CO2 Laser Therapy
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Menopause, Dyspareunia
Multi-point Intra-mucosal Injections of Cross-linked Hyaluronic Acid (DESIRIAL®) in the Vaginal Vestibule
The main objective of this study is to measure changes in the thickness of the vaginal lining (epithelium + underlying stroma) between 0 and 8 weeks after injection.
- Trial name
- INREG 1 (NCT02739880)
- Testing
- DESIRIAL® (Intra-mucosal Injections of Cross-linked Hyaluronic Acid)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Endometriosis
A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain
The primary objective of this study is to demonstrate the efficacy and safety of linzagolix administered orally once daily for 3 months at a dose of 75 mg alone or of 200 mg in combination with add-back hormone replacement…
- Trial name
- NCT03986944
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 112 sites in United States, Canada and 1 more
- Volunteers
- 85 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Provoked Vestibulodynia, Secondary Provoked Vestibulodynia
Topical Ketotifen 0.25% for Secondary Vestibulodynia
This is a Phase 2, multi-center, randomized, double-blind, placebo-controlled trial evaluating the safety and efficacy of topical ketotifen fumarate 0.25% cream in adult women with secondary provoked vestibulodynia (PVD).
- Conditions
- Provoked Vestibulodynia, Secondary Provoked Vestibulodynia, Vulvodynia, Vulvary Pain Disorders
- Trial name
- NCT07257029
- Testing
- Ketotifen Fumarate 0.25% Cream
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- Center for Vulvovaginal Disorders
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Retrospective Cohort Study of Symptoms and Quality of Life in Women With Genitourinary Syndrome of Menopause.
The goal of this clinical trial is to retrospectively identify the most prevalent symptoms of genitourinary syndrome of menopause (GSM) among postmenopausal women and to evaluate their impact on quality of life.
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause (GSM), Quality of Life
- Trial name
- NCT07737782
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Mucosa Innovations, S.L.
Vulvodynia, Vulvar Vestibulitis
Acupuncture for Vulvodynia: A Pre-pilot Study
Vulvodynia is a women's pain condition. Women have pain in their vulva, the area in their genitals between the vagina and labia (lips of the vagina).
- Conditions
- Vulvodynia, Vulvar Vestibulitis, Dyspareunia, Pain
- Trial name
- NCT02704234
- Testing
- Active Acupuncture
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Illinois at Chicago
Vaginitis, Dyspareunia
Vaginal Testosterone Cream For Atrophic Vaginitis in Women Taking Aromatase Inhibitors for Breast Cancer.
Atrophic vaginitis is a condition in which the skin lining of the vagina and labia becomes thin and symptoms develop including vaginal itching, vaginal discomfort and dyspareunia.
- Conditions
- Vaginitis, Dyspareunia, Breast Neoplasms
- Trial name
- NCT01122342
- Testing
- Testosterone propionate
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Vermont
Dyspareunia, Hypoactive Sexual Desire Disorder
Sexual Dysfunction and Dental Care
Evaluation of sexual functioning of patients at the Sexual Medical Center, at Sheba Medical Center in Israel. Sexual functioning shall be compared with their dental behavior. Hypothesis: a positive association will be found.
- Conditions
- Dyspareunia, Hypoactive Sexual Desire Disorder, Erectile Dysfunction, Vaginismus
- Trial name
- NCT00281372
- Volunteers
- 448 people
- Sponsor
- Sheba Medical Center
Genito-Pelvic Pain/Penetration Disorder, Dyspareunia
VIBRating vs Traditional Therapy for Treatment of ENTry Dyspareunia
The goal of this randomized controlled trial is to determine whether the use of a novel vibrating pelvic floor therapeutic device ("Kiwi") improves sexual function in sexually active women aged 18 and older with genito-pelvic…
- Conditions
- Genito-Pelvic Pain/Penetration Disorder, Dyspareunia, Vaginismus, Pelvic Pain
- Trial name
- VIBRENT (NCT06840314)
- Testing
- Pelvic floor therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medstar Health Research Institute
Sexual Dysfunction, Postmenopausal Symptoms
Examination of the Effects of Pelvic Floor Exercises on Vaginal and Sexual Health in Postmenopausal Women.
The purpose of this study; To investigate the effects of pelvic floor muscle exercises on vaginal and sexual health in postmenopausal women.
- Conditions
- Sexual Dysfunction, Postmenopausal Symptoms, Pelvic Floor Muscle Weakness
- Trial name
- NCT06294197
- Testing
- Pelvic Floor Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hatice Gulsah Kurne
Dysmenorrhea, Pelvic Pain
Continuous Versus Cyclic Oral Contraceptives for Endometriosis
To evaluate the efficacy of oral contraceptives in a continuous fashion versus the usual cyclic fashion in the recurrence of endometriosis related symptoms and endometriomas following fertility-sparing surgery.
- Conditions
- Dysmenorrhea, Pelvic Pain, Dyspareunia, Endometrioma
- Trial name
- NCT02237131
- Testing
- Oral contraceptives cyclic, Oral contraceptives continuous
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Athens
Gynecologic Disease, Adnexal Mass
Assessment of Women's Sexual Quality of Life After Benign Adnexal Surgery Using vNOTES Approach
Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a recent innovation in minimally invasive surgery which has already proven its non-inferiority to conventional abdominal laparoscopy (CAL) for hysterectomy…
- Conditions
- Gynecologic Disease, Adnexal Mass, Adnexal Cyst, Sexuality
- Trial name
- NCT05761275
- Testing
- Elective cystectomy, Elective oophorectomy, Elective salpingectomy
- Where
- Switzerland
- Volunteers
- 62 people
- Sponsor
- Jean Dubuisson
Hypoactive Sexual Desire Disorder, Vulvovaginal Disease
Effect of Testosterone Treatment on Clitoral Arteries' Hemodynamic Parameters.
The regulation of clitoral vascularization by sex steroids is still under-investigated. We aimed to explore the effects of 6 months transdermal Testosterone (T) therapy on clitoral color Doppler ultrasound (CDU) parameters in…
- Conditions
- Hypoactive Sexual Desire Disorder, Vulvovaginal Disease, Menopause Related Conditions, Dyspareunia (Female Excluding Psychogenic)
- Trial name
- TESTOFSD (NCT04336891)
- Testing
- Testosterone gel, Estradiol ovules, Moisturizer
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- University of Florence
Deep Infiltrating Endometriosis, Pelvic Pain, Dysmenorrhea Dyspareunia
Nerve Fiber Density in DIE Nodules & Pelvic Pain
Deep infiltrating endometriosis (DIE) is a highly symptomatic form of endometriosis linked to severe dysmenorrhea, dyspareunia, dyschezia, dysuria, and chronic pelvic pain.
- Trial name
- DIENerveDens (NCT07274956)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Dyspareunia, Menopause
Genital Laser Treatment in Postmenopausal Patients
Regulation of sexual functions without hormonal support in order to correct the sexual dysfunctions in women with the estrogen hormone lost in the menopausal process.
- Conditions
- Dyspareunia, Menopause, Sexual Activity, Atrophy Vulva
- Trial name
- NCT05631665
- Testing
- Survey results before and after laser treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Dyspareunia, Vaginal Dryness
Effectiveness and Safety of a Water-based and a Silicone-based Personal Lubricants With Sensory Action
This clinical investigation will look at the effectiveness and safety of two personal lubricants for the relief of intimate discomfort associated with vaginal dryness.
- Trial name
- NCT05644444
- Testing
- Lubricant A (sensate water-based personal lubricant) and Comparator A (non-sensate water-based lubricant), Lubricant B (sensate silicone-based personal lubricant) and Comparator B (non-sensate silicone-based personal lubricant)
- Where
- Germany
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Pelvic Pain, Dyspareunia
A Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction
This study assesses whether the addition of chemodenervation to an established regimen of pelvic floor physical therapy for painful high tone pelvic floor dysfunction improves patients' objective and subjective outcomes.
- Conditions
- Pelvic Pain, Dyspareunia, Pelvic Floor Dysfunction
- Trial name
- NCT03199534
- Testing
- Botulinum toxin A 50u, Botulinum toxin A 100u, Botulinum toxin A 150u
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- EvergreenHealth