Clinical trials: Dysphagia, completed
Esophageal Motility Disorders
Codeine on Pharyngeal and Esophageal Motility
Opioids act on opioid receptors located in the brain as well as in the gastrointestinal (GI) tract to induce changes in motility.
- Trial name
- NCT03784105
- Testing
- Codeine Phosphate, Siripus simplex
- Where
- 2 sites in Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Oropharyngeal Dysphagia
Effect of Pharyngeal Inhibition by rTMS on Swallowing Function
The aim of this study is to test the hypothesis that rTMS on the dominant swallowing hemisphere is able to modify swallowing coordination.
- Trial name
- rTMSvideoSS (NCT02170454)
- Testing
- magnetic stimulation
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Gastroesophageal Reflux
Prevalence of Gastroesophageal Reflux During Childhood and Teenage Years in France
The purpose of this study is to assess prevalence of gastrooesophageal reflux during childhood and teenage years in France and to describe patients'symptoms and gastrooesophageal reflux management
- Trial name
- NCT00681837
- Where
- 25 sites in China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Aspiration of Gastric Contents
SMART Study (Sellick's Maneuver Assisted Real Time) to Deliver Target Cricoid Pressure in Simulated Environment
Cricoid force is applied during airway management to prevent pulmonary aspiration of regurgitated gastric contents. This force is usually applied by a nurse or anaesthesia assistant.
- Trial name
- NCT02749175
- Testing
- Cricoid force sensor monitor system
- Where
- Singapore
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
GERD
A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers
A study to investigate the effect of food on the Pharmacokinetics and pharmacodynamics of CKD-381 in healthy volunteers
- Trial name
- NCT04830930
- Testing
- CKD-381
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
GERD
Twenty-Four Hour Combined Multi-Channel Impedance and pH Ambulatory Monitoring: Impedance Reflux Episodes of Patients On and Off Proton Pump Inhibitor Therapy
The purpose of this study is to determine the effects of proton pump inhibitors (PPIs) on the total number of reflux episodes in the distal esophagus measured by impedance in patients with and without gastroesophageal reflux…
- Trial name
- NCT01710800
- Testing
- Esomeprazole
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Chronic Obstructive Pulmonary Disease
Decreased Tongue Strength is Related to Skeletal Muscle Mass in COPD Subjects
Background: Dysphagia is frequently observed in subjects with chronic obstructive pulmonary disease (COPD). But tongue strength has not been investigated yet in COPD subjects.
- Trial name
- NCT04761380
- Testing
- balloon-based tongue pressure measurement device
- Where
- Japan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kindai University
Healthy Volunteers
Single-dose and Multiple-dose X842 Phase 1 Study
The purpose of this study is to evaluate the safety and tolerability of X842 after administration of single and multiple doses in healthy subjects
- Trial name
- NCT04293965
- Testing
- Single ascending dose of X842, Multiple ascending dose of X842, Food Effect
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
GERD
Physiology of GERD and Treatment Response
This study is designed to assess the physiologic and behavioral mechanisms associated with enhanced medication effects in adult patients with functional GERD-related symptoms.
- Trial name
- NCT04292470
- Testing
- Amitriptyline
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Swallowing Disorder
Compare Swallowing Kinematics and Suprahyoid Muscle Activation Among Three Different Swallowing Tasks
The aim of this study is to swallowing kinematics and suprahyoid muscle activation among Masako, Mendelsohn Maneuvers and new-designed Mouth Open Swallowing Maneuver
- Trial name
- NCT05579041
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Gastro-esophageal Reflux Disease, Functional Dyspepsia
Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia
Our group recently studied the relationship between intra-gastric pressure (IGP) and reflux events after a meal, both in gastro-esophageal reflux disease (GERD) and in healthy volunteers (HV).
- Conditions
- Gastro-esophageal Reflux Disease, Functional Dyspepsia, Health
- Trial name
- NCT03788109
- Testing
- device: combined solid state HRiM
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux Disease
A Study to Compare PK, PD and Safety of the AD-214 10/600mg and Rabeprazole
A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214 10/600mg to Rabeprazole 10mg in healthy volunteers.
- Trial name
- NCT04494243
- Testing
- AD-214 10/600mg, Rabeprazole 10mg
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
GERD
ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
OBJECTIVES To study the safety and efficacy of Endoscopic Anti Reflux Mucosal Ablation (ARMA) procedure for the treatment of proton pump inhibitor (PPI) dependent gastro-esophageal reflux disease (GERD) DESIGN OF THE Prospective…
- Trial name
- ARMA (NCT04243668)
- Testing
- ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA)
- Where
- India
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Acid Reflux Disease, Obstructive Sleep Apnea
Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea
The purpose of this study is to determine if using Pantoprazole decreases your daytime sleepiness and improves your reaction time when compared to using a placebo (sugar pill).
- Trial name
- NCT00307944
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Gastrointestinal Discomfort
Effects of Mucosave® on Gastrointestinal Discomfort
Gastrointestinal (GI) discomfort, which often includes gastroesophageal reflux disease (GERD) is a common disorder in healthy adults affecting 20% of people particularly women.
- Trial name
- NCT04119817
- Testing
- Mucosave® capsules
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico "G. Martino"
Esophagitis, Gastro Oesophageal Reflux Disease
Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum
This investigation is designed to evaluate the acid neutralisation action of a new test product versus unmatched placebo.
- Trial name
- NCT05129670
- Testing
- Calcite chewing gum
- Where
- Ireland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Barrett's Esophagus, GERD
Cytosponge Adequacy Study Evaluation II
This study will assess the Minimally Invasive Esophageal Cytology Collection System in Patients with Barrett's Esophagus or GERD Symptoms.
- Trial name
- CASEII (NCT02395471)
- Testing
- Cytosponge™ Cell Collection Device
- Where
- 5 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastroesophageal Reflux, Laryngopharyngeal Reflux
Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease
This study plans to learn more about reflux associated laryngeal symptoms, and more efficient ways to diagnose and treat this condition.
- Trial name
- NCT03619811
- Testing
- Reflux Band® Upper Esophageal Sphincter (UES) Assist Device
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego