Clinical trials: Dysphagia
Interstitial Lung Disease, Systemic Sclerosis
The Role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis
Scarring of the lungs is common in patients with scleroderma and is one of the main causes of death. Patients with scleroderma very frequently have problems with their gullet (esophagus), the food pipe that leads into the…
- Conditions
- Interstitial Lung Disease, Systemic Sclerosis, Gastroesophageal Reflux
- Trial name
- NCT02136394
- Testing
- Gastro-esophageal reflux
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Deglutition Disorders
Effect Of Piperine In Patients With Oropharyngeal Dysphagia
Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.
- Trial name
- FIS 2009_2 (NCT01383694)
- Testing
- Piperine
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital de Mataró
Asthma, Gastroesophageal Reflux
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma.
- Trial name
- GenARA (NCT03015610)
- Testing
- commercially available lansoprazole
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Jason Lang, M.D., M.P.H.
Voice Disorders, Gastroesophageal Reflux
Quantifying Effects of Treatment of Pediatric Dysphonia
The diagnosis and management of childhood dysphonia is a significant clinical problem; however, there have been few studies aimed at defining standard assessment methods for pediatric dysphonia.
- Trial name
- NCT00237679
- Testing
- Neuromuscular Electrical Stimulation, Unstimulated
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Achalasia
Post Operative Pain Control of POEM Procedure
Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for esophageal achalasia with a natural orifice transluminal endoscopic procedure and far less invasive than the standard surgical or laparoscopic Heller myotomy…
- Trial name
- NCT04177342
- Testing
- Fentanyl, Oxycodone
- Volunteers
- 196 people
- Sponsor
- Chen Wannan
Vocal Fold Palsy, Dysphagia
Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery
The purpose of this study is to determine how often heart or chest surgery in children leads to problems with the movement of the vocal folds.
- Conditions
- Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
- Trial name
- NCT03882450
- Testing
- Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Emory University
Erosive Esophagitis, GERD
Efficacy Study of Ilaprazole to Treat Erosive Esophgitis
This study compared Ilaprazole 20mg with lansoprazole 30mg for the healing of erosive esophagitis and resolution of heartburn.
- Trial name
- NCT01509261
- Testing
- Ilaprazole, Lansoprazole
- Where
- 19 sites in South Korea
- Volunteers
- 292 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Otitis Media With Effusion
Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion
The aim of the study was detection of pepsin in effusion in children with OME using Peptest as new quick and cheap method of detection and comparison results with results of other studies in which pepsin was detected by more…
- Trial name
- NCT02183974
- Testing
- Peptest
- Where
- Czechia
- Volunteers
- 44 people
- Sponsor
- University Hospital Ostrava
Parkinson's Disease, Dysphagia
Combined Stimulation of STN and SNr for Dysphagia in Parkinson's Disease
20 patients with idiopathic Parkinson's disease and dysphagia will be included into this randomised controlled double-blinded parallel group clinical trial.
- Trial name
- NCT03470324
- Testing
- [standard STN], [STN+SNr], Swallowing therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Speech and Language Disorder, Speech Therapy
Providing Speech Therapy Awareness in Private Schools
There has been limited research in the area of speech and language therapy awareness in Pakistan. The study aims to assess the efficacy of providing speech therapy awareness in private schools through a pre-post model.
- Conditions
- Speech and Language Disorder, Speech Therapy, Speech Delay, Swallowing Disorder
- Trial name
- NCT04505696
- Testing
- Speech-Language Pathology Presentation
- Where
- Pakistan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Ineffective Esophageal Motility, GERD (Gastroesophageal Reflux Disease)
The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility
This study aims to assess the influence of specialized products based on ice cream on esophageal motility
- Trial name
- MICE (NCT07121803)
- Testing
- specialized food based on ice cream, order 1, specialized food based on ice cream, order 2, specialized food based on ice cream, order 3
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Clostridium Difficile Infection
Effect of Acid Suppression Medication on Pediatric Microbiome
The colonic microbiome is essential in health and disease, and is highly dynamic during the first several years of life. Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are widely used in children, but…
- Trial name
- NCT02016820
- Testing
- Omeprazole (suspension), Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Stroke, Dysphagia
Treatment of Dysphagia Using the Mendelsohn Maneuver
The primary goal of the investigation is to determine the effects of the Mendelsohn maneuver on the physiology of the swallow in individuals who have suffered a stroke and exhibit signs of pharyngeal dysphagia.
- Trial name
- NCT00592761
- Testing
- Mendelsohn Maneuver
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Arkansas
GERD
Heartburn, Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation.
- Trial name
- GERD (NCT07268820)
- Testing
- Zastaprazan, Esomeprazole
- Where
- 10 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Incheon St.Mary's Hospital
Wallenberg Syndrome
Effect of Virtual Reality Therapy on Dysphagia in Wallenberg Syndrome
The goal of this clinical trial is to learn about on dysphagia in wallenberg syndrome. The main questions it aims to answer are: the efficacy of Virtual Reality Therapy in the rehabilitation of patients with dysphagia in…
- Trial name
- NCT06286020
- Testing
- Virtual Reality Therapy, Conventional dysphagia treatment
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Zeng Changhao
Stroke, Dysphagia
PES to Avoid Extubation Failure in Intubated Stroke Patients at High Risk of Severe Dysphagia
Post-extubation dysphagia (PED) recently became a growing concern as a major risk factor for extubation failure and significant contributor to poor patient outcomes with prevalence rates ranging from 12% to 69%, being highest in…
- Conditions
- Stroke, Dysphagia, Extubation Failure
- Trial name
- NCT04010617
- Testing
- Pharyngeal Electrical Stimulation (PES)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Gastroesophageal Reflux Disease, Hiatal Hernia
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
To study the long term outcome of Laparoscopic Hiatal Hernia Repair with human acellular dermal matrix Alloderm (LifeCell, Branchburg, NJ) mesh.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
- Trial name
- NCT01776827
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Nebraska
Stroke, Dysphagia
Transcranial Direct Current Stimulation for Dysphagia Therapy in Acute Stroke Patients
The purpose of this study is to evaluate whether transcranial direct current stimulation of the cerebral swallow motor cortex in addition to standard care can enhance recovery of swallow function in acute dysphagic stroke…
- Trial name
- NCT01970384
- Testing
- Transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Muenster
Head and Neck Neoplasms, Xerostomia
Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer
Radiotherapy plays an important role in the curative treatment of head and neck cancer. This treatment however is associated with significant acute and late toxicity with xerostomia and dysphagia severely implicating the…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Deglutition Disorders
- Trial name
- NCT01621048
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dysbiosis, Gastroesophageal Reflux Disease (GERD)
Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users
Proton-pump inhibitors (PPIs) are widely used to treat acid-related stomach problems, such as heartburn and acid reflux. Long-term use of PPIs has been linked to changes in the gut bacteria and fungi (called the gut microbiota)…
- Trial name
- NCT07852676
- Testing
- Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI)
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital