Clinical trials: Dysphagia, completed
Abdominal Pain, Deglutition Disorders
Development and Validation of the Automated Evaluation of Gastrointestinal Symptoms (AEGIS) Platform
Through a four-year grant awarded to the University of California at Los Angeles in 2009, Dr. Brennan Spiegel served as a principal investigator (PI) for a project to develop and initially validate a bank of items to assess…
- Conditions
- Abdominal Pain, Deglutition Disorders, Fecal Incontinence, Nausea
- Trial name
- NCT02436057
- Testing
- AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
- Where
- 3 sites in United States
- Volunteers
- 255 people
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Acute, Swallowing Disorder
Functionality, Cognition And Swallowing Skills In Patients With AcuteSTROKE
Aim: Studies in which the results of the screening test evaluating swallowing skills in acute stroke patients are evaluated together with other components that may affect swallowing function are limited.
- Conditions
- Stroke, Acute, Swallowing Disorder, Cognitive Impairment, Stroke
- Trial name
- NCT06288243
- Testing
- Clinician-observed assessment tests
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Medipol University
Benign Esophageal Lesions
SX ELLA Esophageal Degradable BD Stent System
The SX-ELLA Stent Esophageal Degradable BD (BD Stent) is designed for dilation of benign esophageal lesions, namely: (1) stenosis (peptic, anastomotic or caustic) refractory to standard therapy, (2) achalasia refractory to…
- Trial name
- DESTINY (NCT01337206)
- Testing
- Stenting with ELLA Biodegradable stent, Standard Dilations
- Where
- 8 sites in Belgium, Italy and 3 more
- Volunteers
- 66 people
- Sponsor
- Cook Group Incorporated
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Mitral Valve Regurgitation
Early Feasibility Study of the Neovasc Tiara™ Mitral Valve System
The purpose of this study is to evaluate the safety and initial performance of the Neovasc Tiara Mitral Transcatheter Heart Valve with the Tiara Transapical Delivery System.
- Trial name
- TIARA-I (NCT02276547)
- Testing
- Mitral valve replacement
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 27 people
- Sponsor
- Shockwave Medical, Inc.
Dysphagia, Dysphonia
Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery
Evaluate voice and swallowing outcomes post operatively.
- Trial name
- NCT01017055
- Testing
- Voice and Swallowing evaluations
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Gastroesophageal Reflux Disease
Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
BACKGROUND: Gastroesophageal reflux disease is a very frequent clinical condition and nocturnal symptoms are a cause of quality of life impairment, poor sleep quality and absenteeism.
- Trial name
- IBELGA (NCT02706938)
- Testing
- Head of bed elevation, Standard treatment
- Where
- Colombia
- Volunteers
- 65 people
- Sponsor
- Universidad Nacional de Colombia
Achalasia, Alacrima
Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of…
- Trial name
- AAAS (NCT00856921)
- Volunteers
- 19 people
- Sponsor
- Asan Medical Center
Gastroesophageal Reflux Disease
Comparison of the Nighttime Effects of Two Different Drugs on Subjects With GERD
The purpose of the study is to compare the effect of two different drugs, rabeprazole (20 mg) and pantoprazole (40 mg), and their effects on the amount of acid produced by your stomach on evening and at night after standard…
- Trial name
- NCT00304421
- Testing
- rabeprazole, pantoprazole
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Thymidine Kinase 2 (TK2)
A RETROspective Study of Patients With TK2d
This is a medical chart review study to collect information for patients who have been taking pyrimidine nucleosides for treatment of TK2 deficiency.
- Trial name
- RETRO (NCT03701568)
- Testing
- dC/dT
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 38 people
- Sponsor
- Zogenix MDS, Inc.
Extraesophageal Reflux
Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic Option
The diagnostics of extraesophageal reflux (EER) is challenging. Currently, 24-h dual-probe esophageal pH monitoring or impedance is considered the best diagnostic method for EER.
- Trial name
- NCT03904758
- Testing
- Pepsin in saliva test
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Ostrava
Gastroesophageal Reflux Disease
The Study to Describe Symptom Control and Impact on Daily Life in Gastroesophageal Reflux Disease (GERD) Patients
The purpose of this study is to evaluate symptoms control and impact on daily life from patients perspective using specific GERD Impact Scale(GIS) questionnaire.
- Trial name
- NCT01200550
- Where
- 23 sites in Bosnia and Herzegovina
- Volunteers
- 1,233 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux
Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to determine the effect of vonoprazan compared to esomeprazole for preventing heartburn symptoms over a 4-week treatment period in participants who have a partial response to treatment with…
- Trial name
- NCT02743949
- Testing
- Vonoprazan, Esomeprazole
- Where
- 39 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 256 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease
The aim of this study was to evaluate the effect of 14 days treatment with Pantoprazole 40 mg and 20 mg on gastroesophageal reflux disease (GERD) related symptoms in a large patient population.
- Trial name
- PARADE (NCT00829738)
- Testing
- Pantoprazole
- Where
- 717 sites in Germany
- Volunteers
- 4,188 people
- Sponsor
- Nycomed
Gastroesophageal Reflux, Heartburn
A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD)
The purpose of the study is to confirm the safety and effectiveness of rabeprazole in the treatment of patients with erosive or ulcerative gastroesophageal reflux disease (GERD) in routine primary health care.
- Trial name
- NCT00216489
- Testing
- rabeprazole sodium
- Volunteers
- 191 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Achalasia
POEM Anterior Versus Posterior Approach
Per-oral endoscopic myotomy (POEM) is an incisionless procedure used to treat esophageal achalasia, performed by GI endoscopist without cutting any surface of the human body.
- Trial name
- NCT02454335
- Testing
- Peroral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Gastroesophageal Reflux
Safety and Efficacy of Lansoprazole in Patients With Reflux Disease
The purpose of this study is to measure the safety, efficacy and quality of life of lansoprazole in patients with reflux disease over a five year period.
- Trial name
- NCT01135368
- Testing
- Lansoprazole
- Volunteers
- 506 people
- Sponsor
- Takeda
Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.
- Conditions
- Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux, GERD
- Trial name
- NCT03735862
- Testing
- Hepatic derived surgical matrix
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Miromatrix Medical Inc.
Hiatal Hernia, GERD
Laparoscopic Total Left-sided Surgical Approach Versus Traditional Bilateral Surgical Approach for Hiatal Hernia
Background: In China, guidelines for the treatment of hiatal hernia (HH) are lacking. Furthermore, efficacy and safety assessments of surgical approaches for HH and for the protection of the vagus nerve and organ function are…
- Trial name
- NCT06828627
- Testing
- TLSA, TBSA
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Friendship Hospital
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
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